1991
DOI: 10.1016/0278-2391(91)90223-9
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Medical and dental implications of cocaine abuse

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Cited by 28 publications
(34 citation statements)
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“…2 In addition, cocaine blocks the re-uptake of norepinephrine and dopamine, which prolongs and increases the effects of these neurotransmitters. 6 Stimulation of the dopamine system induces a feeling of euphoria and arousal. Symptoms are light-headedness, dizzi ness, blurred vision, tinnitus and disori entation.…”
Section: Systemic Effectsmentioning
confidence: 99%
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“…2 In addition, cocaine blocks the re-uptake of norepinephrine and dopamine, which prolongs and increases the effects of these neurotransmitters. 6 Stimulation of the dopamine system induces a feeling of euphoria and arousal. Symptoms are light-headedness, dizzi ness, blurred vision, tinnitus and disori entation.…”
Section: Systemic Effectsmentioning
confidence: 99%
“…Other symptoms are paranoia, hallucinations, restlessness, aggressive behaviour, delirium, vomiting, trem ors, shivering, insomnia, dilated pupils, hyperthermia, hypertension, tachycardia and an increased respiration rate. 2,[4][5][6] With increasing doses of cocaine, these initial signs of central nervous system excitation are rapidly followed by a gen eralised state of central nervous system depression, resulting in a decreased res piration rate with periods of apnoea. 2,6 The sympathomimetic effect of cocaine results in an increased heart rate and an increased oxygen demand of the myocardium.…”
Section: Systemic Effectsmentioning
confidence: 99%
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“…These include gingival and mucosal ulceration and periodontitis [10][11][12] which occur following chronic gingival application. This is thought to occur as a result of the ischaemic vasoconstricting action of the drug.…”
Section: Discussionmentioning
confidence: 99%