Mediators of the homeostasis and effector functions of memory Th2 cells as novel drug targets in intractable chronic allergic diseases

Yeon, Seung-min; Choi, Aryeong; Hong, Min Jeong; Jung, Yong Woo

doi:10.1007/s12272-019-01159-4

Cited by 5 publications

(3 citation statements)

References 124 publications

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“…Asthma is a common, noncommunicable, chronic disease that affects ~ 334 million people worldwide (Bonser and Erle 2017 ). It is mainly characterized by airway inflammation, immunoglobulin E (IgE) generation, and production of type 2 helper T cell (Th2) cytokines (Sethi et al 2019 ; Yeon et al 2019 ). Various inflammatory cells, including lymphocytes, mast cells, eosinophils, and sputum granulocytes, are recruited and aggravate asthma by releasing granule proteins or inflammatory mediators (Kim et al 2016 ; Chen et al 2020a ).…”

Section: Introductionmentioning

confidence: 99%

The effects of BRL-50481 on ovalbumin-induced asthmatic lung inflammation exacerbated by co-exposure to Asian sand dust in the murine model

et al. 2022

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Asian sand dust (ASD), which mainly originates in China and Mongolia in the spring and blows into Korea, can exacerbate respiratory and immunological diseases. This study aims to observe effects of co-exposure to ASD on ovalbumin (OVA)-induced asthmatic lung inflammation and of treatment with a phosphodiesterase 7 (PDE7) inhibitor in a mouse model. The challenge with OVA increased airway hyperresponsiveness (AHR) and inflammatory cell infiltration into the lung tissue. Interleukin (IL)-13, tumor necrosis factor-alpha, monocyte-protein-1, mucin, and antigen-specific IgE and IgG1 production increased in mouse serum. The co-exposure of ASD significantly exacerbated these effects in this asthma model. Notably, the administration of a PDE7 inhibitor, BRL-50481 (BRL), significantly reduced AHR, infiltration of inflammatory cells into the lungs, and the levels of type 2 T helper cell-related cytokines, antigen-specific immunoglobulins, and mucin. Thus, the administration of BRL ameliorated OVA-induced allergic asthmatic responses exacerbated by co-exposure to ASD. This study suggests that PDE7 inhibition can be a therapeutic strategy for inflammatory lung diseases and asthma via the regulation of T lymphocytes and reduction of IL-13, and, consequently, mucin production. Supplementary Information The online version contains supplementary material available at 10.1007/s12272-021-01367-x.

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Section: Introductionmentioning

confidence: 99%

The effects of BRL-50481 on ovalbumin-induced asthmatic lung inflammation exacerbated by co-exposure to Asian sand dust in the murine model

et al. 2022

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“…5 Yet, we do not have satisfactory methods to regulate the skewed Th2 response in subjects with allergic diseases currently. 6 Therefore, it is necessary to further investigate the pathogenesis of the skewed Th2 response and design proper methods to adjust it.…”

Section: Introductionmentioning

confidence: 99%

“…Re‐exposure to specific antigens drives the sensitized mast cells to release chemical mediators to trigger an allergic response . Yet, we do not have satisfactory methods to regulate the skewed Th2 response in subjects with allergic diseases currently . Therefore, it is necessary to further investigate the pathogenesis of the skewed Th2 response and design proper methods to adjust it.…”

Section: Introductionmentioning

confidence: 99%

CARsomes inhibit airway allergic inflammation in mice by inducing antigen‐specific Th2 cell apoptosis

Zhang

Sun

Lin

et al. 2020

Allergy

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Background: Skewed T helper (Th)2 response plays a crucial role in the pathogenesis of allergic diseases. The therapeutic efficacy for allergic diseases is unsatisfactory currently. This study aims to regulate the skewed Th2 response with CARsomes. Methods: The CARsome consisted of an epitope of Dermatophagoides farina-1 (Derf1), a segment of the anti-DEC205 antibody, the scFv, and an open reading frame of perforin. This fusion protein binds to DEC205 molecule on the surface of exosomes derived from dendritic cells (DC). The effects of CARsome on inducing antigen (Ag)specific Th2 cell apoptosis were assessed both in vivo and in vitro.

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Enoximone alleviates atopic dermatitis-like skin inflammation via inhibition of type 2 T helper cell development

Song,

Lee,

Lee

et al. 2024

International Immunopharmacology

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Mediators of the homeostasis and effector functions of memory Th2 cells as novel drug targets in intractable chronic allergic diseases

Cited by 5 publications

References 124 publications

The effects of BRL-50481 on ovalbumin-induced asthmatic lung inflammation exacerbated by co-exposure to Asian sand dust in the murine model

The effects of BRL-50481 on ovalbumin-induced asthmatic lung inflammation exacerbated by co-exposure to Asian sand dust in the murine model

CARsomes inhibit airway allergic inflammation in mice by inducing antigen‐specific Th2 cell apoptosis

Enoximone alleviates atopic dermatitis-like skin inflammation via inhibition of type 2 T helper cell development

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