Mediator mechanisms of cathinone effects on animal behaviour

Babayan, E.; Barkov, N. K.; Machula, A. I.

doi:10.1016/0376-8716(83)90052-2

Cited by 11 publications

(4 citation statements)

References 7 publications

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“…Interestingly, the affinity for serotonin receptors by cathinone was found to be about four times higher than amphetamine (18). This finding along with that of Babayai et al (19) suggested that activation of the serotonin pathways may have an important role in action of cathinone compared to amphetamine.…”

Section: Structure Of Cathinone Cathine (Norpseudoephedrine) and Amsupporting

confidence: 69%

Mechanism of action of cathinone: The active ingredient of Khat ( Catha Edulis

Nb¹

2009

E Af Med Jrnl

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Objective: To review the current understanding of the mechanism of action of cathinone, the active ingredient of khat. Data source: Published experimental studies on the nature and action and effect of cathinone on the central nervous system both in animals and humans. Data extraction: Data was taken from work published on the mechanism of action of cathinone and also from work where the action of cathinone and amphetamine was compared. Data synthesis: Data from various studies on cathinone was compared for common themes with regards to its action and similarity with the known mechanism of action of amphetamine. Conclusion:The experimental work shows that cathinone is a liable substance, structually related to amphetamine, and similarly to amphetamine, increases the levels of dopamine in the brain by acting on the cathecholaminergic synaspes. Hence the psychostimulant effect of khat can be accounted for by the mechanism of cathinone, which is considered to be its main active ingredient.

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Section: Structure Of Cathinone Cathine (Norpseudoephedrine) and Amsupporting

confidence: 69%

Mechanism of action of cathinone: The active ingredient of Khat ( Catha Edulis

Nb¹

2009

E Af Med Jrnl

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“…however, indications in the literature that interaction with serotoninergic neurons might be a quite important aspect in the overall effect of the khat alkaloid. Thus, it has been reported that (-)-cathinone decreases the ability of cats to differentiate between visual stimuli, and that this decrease does not occur when the animals are pre treated with either the serotonin synthesis blocker pchlorphenylalanine or the serotonin receptor antagonist methysergide [14], Furthermore, by using a two-lever drug discrimination procedure it was found that rats trained with the serotonin agonist quipazine were less likely to distinguish between (-)-cathinone and quipazine than between (+)-amphetamine and quipa/ine [15], This observation correlates with results indicating that the affinity of (-)-cathinone for rat fundus serotonin recep tors is four times higher than that of racemic amphet amine [16], It is possible, therefore, that due to higher activity at postsynaptic sites, (-)-cathinone has a gener ally more pronounced effect on serotoninergic neuro transmission than (+)-amphetamine, and it would be of interest to investigate this further. With regard to release from serotonin storage sites, however, (-)-cathinone ap pears to have no greater specificity than (-^-amphet amine.…”

Section: Discussionmentioning

confidence: 99%

Effect of the Alkaloid (–)-Cathinone on the Release of Radioactivity from Rat Striatal Tissue Prelabelled with 3H-Serotonin

Kalix¹

1984

Neuropsychobiology

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The alkaloid (–)-cathinone, which accounts for the stimulating properties of khat leaves, has a pharmacological profile closely resembling that of (+)-amphetamine. Since amphetamine is known to induce release at CNS serotonin storage sites, experiments were performed to determine whether (–)-cathinone also displays this aspect of amphetamine action. When the effects of (–)-cathinone and (+)-amphetamine on the release of radioactivity from rat striatal tissue prelabelled with 3H-serotonin were compared, it was found that (–)-cathinone had a releasing effect similar to that of (+)-amphetamine, although it was only one third as potent. Thus, the khat alkaloid (–)-cathinone appears to share an important effect of (+)-amphetamine on serotoninergic neurotransmission.

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“…In vitro studies, for instance, have shown that cathinone enhances the release of serotonin from the striatum [70,71] and can bind to serotonin receptors [72] . A study by Fleckenstein et al [73] demonstrated serotonin uptake inhibition by cathinone following single or multiple dosing.…”

Section: Khat and Monoaminesmentioning

confidence: 99%

Khat (Catha edulis) and Obesity: A Scoping Review of Animal and Human Studies

et al. 2016

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Background: Khat (Catha edulis) is a plant that is deeply rooted in the cultural life of East African and Southwestern Arabian populations. Prevalent traditional beliefs about khat are that the plant has an effect on appetite and body weight. Summary: This review assesses the accumulated evidences on the mutual influence of monoamines, hormones and neuropeptides that are linked to obesity. A few anti-obesity drugs that exert their mechanisms of action through monoamines are briefly discussed to support the notion of monoamines being a critical target of drug discovery for new anti-obesity drugs. Subsequently, the review provides a comprehensive overview of central dopamine and serotonin changes that are associated with the use of khat or its alkaloids. Then, all the studies on khat that describe physical, biochemical and hormonal changes are summarised and discussed in depth. Conclusion: The reviewed studies provide relatively acceptable evidence that different khat extracts or cathinone produces changes in terms of weight, fat mass, appetite, lipid biochemistry and hormonal levels. These changes are more pronounced at higher doses and long durations of intervention. The most suggested mechanism of these changes is the central action that produces changes in the physiology of dopamine and serotonin. Nonetheless, there are a number of variations in the study design, including species, doses and durations of intervention, which makes it difficult to arrive at a final conclusion about khat regarding obesity, and further studies are necessary in the future to overcome these limitations.

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Mediator mechanisms of cathinone effects on animal behaviour

Cited by 11 publications

References 7 publications

Mechanism of action of cathinone: The active ingredient of Khat (<i> Catha Edulis</i>

Mechanism of action of cathinone: The active ingredient of Khat (<i> Catha Edulis</i>

Effect of the Alkaloid (–)-Cathinone on the Release of Radioactivity from Rat Striatal Tissue Prelabelled with <sup>3</sup>H-Serotonin

Khat (<b><i>Catha edulis</i></b>) and Obesity: A Scoping Review of Animal and Human Studies

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