Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix–loop–helix repressor of neuronal differentiation

Adoptive Transfer of Heme Oxygenase-1 (HO-1)-Modified Macrophages Rescues the Nuclear Factor Erythroid 2-Related Factor (Nrf2) Antiinflammatory Phenotype in Liver Ischemia/Reperfusion Injury

“…Overexpression of HO-1 after adoptive transfer of genetically modified BMMs into Nrf2-deficient livers upregulated the expression of Hes1, a Notch downstream effector molecule crucial for the regulation of cell cycle and survival (37,38). Indeed, as a transcriptional regulator, Hes1 has been shown to control differentiation/proliferation of neuronal, endocrine and T-lymphocyte progenitors during cell development (39)(40)(41). Induction of Hes1 increases cell survival by directly controlling the activity of transcriptional repression of a cyclin-dependent kinase inhibitor p27 Kip1 (42).…”

Protein Kinase C Activates Human Lipocalin-type Prostaglandin D Synthase Gene Expression through De-repression of Notch-HES Signaling and Enhancement of AP-2β Function in Brain-derived TE671 Cells

“…A previous report (44) indicated that the DNA-binding domain of Hes-1 was phosphorylated by PKC and that phosphorylated Hes-1 lost its DNA-binding ability. At first, we investigated whether Hes-1 in TE671 cells is phosphorylated by PKC.…”

Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates

“…Additionally, members of this family such as the Drosophila Enhancer of split genes and certain mammalian Hairy/Enhancer of s គplit (HES) genes are important effectors of the Notch signaling pathway, which controls neuronal cell fate decisions in both vertebrates and Drosophila (Kageyama and Nakanishi 1997;Robey 1997;Fisher and Caudy 1998). The mammalian HES-1 protein is also a functional target for Nerve Growth Factor (NGF) signaling in the PC12 cell line (Strö m et al 1997). In these various pathways, the Hairy-related proteins act genetically as repressors of target genes in vivo.…”