Mediation analysis reveals a sex-dependent association between ABO gene variants and TG/HDL-C ratio that is suppressed by sE-selectin level

Teng, Michelle H.; Hsu, Lung‐An; Wu, Semon; Chou, Hsin Hua; Chang, Chi Jen; Sun, Yeying; Juan, Shu Hui; Ko, Yu‐Lin

doi:10.1016/j.atherosclerosis.2013.03.032

Cited by 29 publications

(33 citation statements)

References 32 publications

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“…In several clinical researches as well as studies investigating the effects of genetic variants [29][30][31], mediation analysis has been used to assess an intermediate variable as a mediator in the pathway between a risk factor and an outcome to estimate the extent to which the effect of the risk factor occurs through the mediator. In the current study, we performed this analysis and specifically found that both sdLDL-C and large HDL-C were partly mediated this relationship, however, only 8.7-10.5% effect size has been mediated, which may suggest that SUA probably plays an important role in the development of CAD by itself or through other pathways.…”

Section: Tablementioning

confidence: 99%

Lipoprotein subfractions partly mediate the association between serum uric acid and coronary artery disease

Zhang

et al. 2015

Clinica Chimica Acta

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Section: Tablementioning

confidence: 99%

Lipoprotein subfractions partly mediate the association between serum uric acid and coronary artery disease

Zhang

et al. 2015

Clinica Chimica Acta

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“…For instance, variants of the ABO and CDH13 genes (which encode the ABO histo-blood group antigen and glycosylphosphatidylinositol-anchored cadherin 13, respectively) were reported to associate with sICAM1 levels [10, 17, 18]. Recently, a GWAS identified and localized the genetic determinants of sICAM1 levels to several loci in the genome, including two SNPs, rs3136642 and rs1049728, in the NFKBIK and RELA genes which function in the NF-κB pathway [11].…”

Section: Introductionmentioning

confidence: 99%

Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese

Teng

et al. 2017

PLoS ONE

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Intercellular adhesion molecule–1 (ICAM1) is crucial to the development and progression of atherosclerosis. Recent genome-wide association studies (GWAS) have revealed that single nucleotide polymorphisms (SNPs) in two of the nuclear factor-κB (NF-κB) pathway genes, NFKBIK and RELA, are associated with soluble ICAM1 (sICAM1) levels. However, neither of these two gene variants is found in the Asian populations. This study aimed to elucidate whether other candidate gene variants involved in the NF-κB pathway may be associated with sICAM1 levels in Taiwanese. After excluding carriers of the ICAM1 rs5491-T allele, three SNPs in the ICAM1 gene and eight SNPs in six of the NF-κB pathway genes (NFKB1, PDCD11, TNFAIP3, NKAPL, IKBKE, and PRKCB) were analyzed for their association with sICAM1 levels in 480 individuals. Our data showed that two SNPs, rs5498 of ICAM1 and rs1635 of NKAPL, were significantly associated with sICAM1 levels (P = 0.002 and 0.004, respectively) in the Taiwanese population. Using a multivariate analysis, rs5498 and rs1635 as well as the previously reported ABO genotypes and rs12051272 of the CDH13 gene were independently associated with sICAM1 levels (P = 0.001, 0.001, 0.006 and 0.031, respectively). An analysis with combined risk alleles of four candidate SNPs in the ICAM1, NKAPL, ABO, and CDH13 genes showed an increase in sICAM1 levels with added numbers of risk alleles and weighted genetic risk score. Our findings thus expanded the repertoire of gene variants responsible for the regulation of sICAM1 levels in the Asian populations.

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“…As possible links between ABO blood groups and CAD pathogenesis, previous studies have emphasized the increased prothrombotic state, higher prevalence of traditional cardiovascular risk factors, and higher level of systemic inflammatory response revealed in patients with different ABO blood groups [3][4][5]. Recently, genome-wide association studies (GWAS) have revealed significant associations of genetic variants in the ABO blood group region with levels of various inflammatory markers, including soluble levels of E-selectin (sE-selectin), intercellular adhesive molecule 1 (ICAM1), and P-selectin (sP-selectin) [6].…”

mentioning

confidence: 99%

High-sensitivity C-reactive protein mediates in part the impact of ABO blood group on coronary artery disease

Gong¹,

Li²,

Luo³

et al. 2014

International Journal of Cardiology

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Mediation analysis reveals a sex-dependent association between ABO gene variants and TG/HDL-C ratio that is suppressed by sE-selectin level

Cited by 29 publications

References 32 publications

Lipoprotein subfractions partly mediate the association between serum uric acid and coronary artery disease

Lipoprotein subfractions partly mediate the association between serum uric acid and coronary artery disease

Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese

High-sensitivity C-reactive protein mediates in part the impact of ABO blood group on coronary artery disease

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