Mediastinal Paraganglioma

Buchanan, Stephanie N.; Radecki, Kevin M.; Chambers, Lowell W.

doi:10.1016/j.athoracsur.2016.10.031

Cited by 22 publications

(20 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Complete surgical excision with negative margins is the treatment of choice. 4,5 These tumors being highly vascular, preoperative embolization has been suggested to aid surgery. 6,7 This also prevents hypertensive crisis secondary to a hormonal surge in the circulation during surgical manipulation.…”

Section: Discussionmentioning

confidence: 99%

Management dilemma in case of a posterior mediastinal paraganglioma

Bohra

Srikrishna

Kaskar

2019

Asian Cardiovasc Thorac Ann

View full text Add to dashboard Cite

We report a case of functional mediastinal paraganglioma supplied by the left circumflex artery, associated with bilateral carotid body tumors. The surgical approach for a tumor in the posterior mediastinum behind the left atrium was a dilemma because the majority of the tumor was in the right hemithorax but its major blood supply was from the left circumflex artery in the left hemithorax. Management involved preoperative coil embolization of the feeding vessel followed by complete excision of the tumor through a right thoracotomy, without employing cardiopulmonary bypass, and excision of the carotid body tumors in a staged manner.

show abstract

Section: Discussionmentioning

confidence: 99%

Management dilemma in case of a posterior mediastinal paraganglioma

Bohra

Srikrishna

Kaskar

2019

Asian Cardiovasc Thorac Ann

View full text Add to dashboard Cite

show abstract

“…Therefore, complete surgical resection is considered the treatment of choice in functional and non-functional endothoracic paragangliomas (1,(8)(9)(10)(11)(12)14,(16)(17)(18)(19)22,32,33); in fact, these tumors are relatively resistant to chemotherapy and radiotherapy (1,11,19,32).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary and mediastinal paragangliomas: rare endothoracic malignancies with challenging diagnosis and treatment

Palma¹,

Lorusso²,

Gennaro³

et al. 2018

J. Thorac. Dis

View full text Add to dashboard Cite

Background: Pulmonary and mediastinal paragangliomas are rare tumors that may have neuroendocrine activity or be non-functional, incidental, in asymptomatic patients, or causing mass effect symptoms. Although being low-grade tumors, they can display an aggressive behaviour, developing local infiltration and distant metastases. We report our experience with three endothoracic paragangliomas and a Literature review, to point out diagnostic difficulties and problems related to surgical treatment. Methods: From 2009 to 2017, we treated 3 patients with histological diagnosis of paraganglioma: 2 pulmonary, 1 mediastinal. No one presented catecholamine-secreting syndromes; pulmonary cases were asymptomatic, while the mediastinal one had aspecific cough and dyspnea. Imaging diagnosis was based on chest computerized tomography (CT) and magnetic resonance imaging (MRI) scan. No patient had preoperative histological diagnosis. Intraoperative pathological examination was suggestive for malignancy: in pulmonary cases, wedge resection and lobectomy were performed; the middle mediastinal mass was completely removed after challenging dissection, isolation and section of numerous vascular pedicles. Results: Postoperative course was uneventful in all cases. No patient received adjuvant treatments. At a median follow-up of 47 months (range, 6-102 months), two patients are alive, without local or distant recurrence; one patient died 6 months after surgery, due to disease progression. Conclusions: Endothoracic paragangliomas, rare and often asymptomatic tumors, are of difficult diagnosis and should be considered malignant tumors, due to the potential aggressive behaviour of cases with high mitotic index and the frequent possibility of recurrence and metastases. Surgical resection is the treatment of choice and careful intraoperative manipulation is recommended, due to the high vascularity of these tumors, to prevent complications. After complete excision, long-term prognosis is generally good. However, even after surgical removal, a close, periodical and lifelong follow-up is mandatory.

show abstract

“…Mediastinal paragangliomas are very uncommon. Most published literature about this tumor is in the form of single case reports 3‐6,8‐10 or case series of fewer than 15 cases each accumulated over a very long period of time at tertiary academic centers 11,12 . Brown et al 11 from Mayo Clinic in Rochester, MN, provided an excellent review of this topic.…”

Section: Figurementioning

confidence: 99%

Surgical management of mediastinal paraganglioma: All hands on deck!

2020

View full text Add to dashboard Cite

Mediastinal paragangliomas are very uncommon neuroendocrine neoplasms. Due to their tissue of origin (sympathetic ganglia of the great vessels), they tend to arise deep within pericardial space and, more importantly, intimately attached to great vessels, which makes surgical resection, even with cardiopulmonary bypass, very challenging. This commentary accompanies the case report describing complex surgical management of a paraganglioma located in the anterior mediastinum that was initially thought to be a thymoma.

show abstract

Mediastinal Paraganglioma

Cited by 22 publications

References 6 publications

Management dilemma in case of a posterior mediastinal paraganglioma

Management dilemma in case of a posterior mediastinal paraganglioma

Pulmonary and mediastinal paragangliomas: rare endothoracic malignancies with challenging diagnosis and treatment

Surgical management of mediastinal paraganglioma: All hands on deck!

Contact Info

Product

Resources

About