Mediastinal lymphomas: Differential diagnosis

Mihaljević, Biljana; Jaković, Ljubomir; Jankovic, Snezana; Jovanović, Marina; Milosevic, Violeta; Anđelić, Boško; Sretenović, Aleksandra; Petrović, Milan

doi:10.2298/vsp0802167m

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…In mediastinal NHL, in addition to the manifestations of shortness, systemic complaints were also found, such as body weakness, fever, and weight loss. In addition, there can be superior vena cava syndrome (VCSS), chest pain, hoarseness, and abdominal fluid (ascites) (Mihaljevi et al 2014). In this patient, we found shortness of breath, swelling of the face and neck due to VCSS, and weight loss.…”

Section: Discussionmentioning

confidence: 70%

Mediastinal Non-Hodgkin's Lymphoma Metastatic to Right Atrium Mimicking Right Atrial Myxoma

Khusnurrokhman

Wulandari

2021

FMI

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Highlight:A 32-year-old male patient suffered mediastinal non-hodgkin's lymphoma metastatic to the right atrium which mimicked right atrial myxoma.The patient died of suspected mediastinal NHL thromboembolism that spread in the right atrium. Abstract:In this case report, the anatomical pathology results in the form of B cell type LNH, but at the age of 32 years and the risk factor in this patient was a former active smoker. In the anatomical pathology results, the results of the B-High Grade Cell Type LNH were also obtained. B-cell type non-hodgkin’s lymphoma can be mutated in the MYC gene (v-myc avian myceloctomatosis viral oncogene homolog) and the BCL-2 and BCL-6 (B-cell lymphoma) genes. If this morphology is found, then the patient's prognosis is poor. Most of these patients were males and the incidence was in the mediastinal area. Mediastinal NHL could develop and enlarge to involve the heart and pericardium. The spread could occur directly and lymphogens. These metastatic tumors were often misdiagnosed with atrial myxoma. In this case report, exploration of the right atrium and open mediastinal biopsy was performed. An open biopsy of the mediastinum revealed a mediastinal mass that enlarged to enter the right atrium. Atrial myxoma was not found. Primary lymphoma growth could also occur in the heart. This condition was called primary cardiac lymphoid (PCL). This case was very rare and was often considered an atrial myxoma. The patient died 10 days after discharge from the hospital. While the patient was eating, the patient had a seizure and the patient was immediately taken to the emergency department of Dr. Soetomo General Academic Hospital, Surabaya, and entered the ER (Resuscitation) ER room, but the patient died after being assisted for approximately two hours. Most likely the cause of the patient's death was a thromboembolic tumor in the right atrium that was released, so that it entered the bloodstream of the brain, causing the patient to have seizures. It was suspected that the cause of the patient's death was the presence of a tumor thrombus that separated into an embolism from the right atrium due to the large size of the tumor. Patients suffering from high rate NHL had a greater percentage of suffering from tumor thromboembolism as many as 10.6% compared to the Low type and Hodgkins lymphoma (LH) (5.8% and 7.25%).

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Section: Discussionmentioning

confidence: 70%

Mediastinal Non-Hodgkin's Lymphoma Metastatic to Right Atrium Mimicking Right Atrial Myxoma

Khusnurrokhman

Wulandari

2021

FMI

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“…Mediastinal mass is a predictor of the future course of the disease of certain lymphomas. Involvement of mediastinum exists in all subtypes of lymphoma, and the most common are the following: classical Hodgkin lymphoma (cHL) -nodular sclerosis, non-Hodgkin lymphoma (NHL) diffuse large B-cell lymphoma (DLBCL), primary mediastinal lymphoma with sclerosis (PMBL) and T-lymphoblastic lymphoma (9).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Mediastinal Mass in Patients With Diffuse Large B-Cell Lymphoma Cs Ii – Case Study

Simonovic¹

2014

AMM

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Diffuse large B-cell lymphoma with primary involvement of mediastinal lymph nodes is a separate nosological entity that should be distinguished from primary mediastinal large B-cell lymphoma. In most cases, DLBCL with primary involvement of the mediastinum has a poor prognosis.International Prognostic Index IPI (age, Ann Arbor clinical stage, Eastern Cooperative Oncology Group (ECOG) performance status, serum LDH, extranodal involvement) and new R-IPI classify patients with DLBCL in certain risk groups and affect the choice of treatment.Clinical stage II in case of patients with DLBCL does not stand for negative prognostic factor. However, the presence of bulky disease in these patients may affect subsequent treatment.Patients with the same IPI risk may have a different response to the applied therapy. For that reason, today, the clinical IPI score must be considered along with biological factors or FDG-PET scan findings.

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“…[ 5 ] On the other hand, about 10% of lymphomas involving the mediastinum are primary, of which T-cell LBL is very rare. [ 6 7 ] In the NHL Classification Project, only 13% T-cell LBLs had Stages 1 or 2 disease. [ 4 ] Patients with T-cell LBL often present with shortness of breath due to either compression of the SVC or pleural or pericardial effusion.…”

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confidence: 99%

Contrast-enhanced fluorodeoxyglucose positron emission tomography/contrast-enhanced computed tomography in mediastinal T-cell lymphoma with superior vena cava syndrome

et al. 2016

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Mediastinal lymphomas: Differential diagnosis

Cited by 3 publications

References 9 publications

Mediastinal Non-Hodgkin's Lymphoma Metastatic to Right Atrium Mimicking Right Atrial Myxoma

Mediastinal Non-Hodgkin's Lymphoma Metastatic to Right Atrium Mimicking Right Atrial Myxoma

Prognostic Significance of Mediastinal Mass in Patients With Diffuse Large B-Cell Lymphoma Cs Ii – Case Study

Contrast-enhanced fluorodeoxyglucose positron emission tomography/contrast-enhanced computed tomography in mediastinal T-cell lymphoma with superior vena cava syndrome

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