Median Urinary Iodine Concentrations Are Indicative of Adequate Iodine Status among Women of Reproductive Age in Prey Veng, Cambodia

Karakochuk, Crystal D; Michaux, Kristina D.; Chai, Tze Lin; Chan, Benny B.; Whitfield, Kyly C.; Barr, Susan I.; McLean, J.; Talukder, Aminuzzaman; Kroeun, Hou; Ly, Sokhoing; Green, Timothy

doi:10.3390/nu8030139

Cited by 6 publications

(7 citation statements)

References 17 publications

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“…The results are similar to the NFCS-FB-1 of nonpregnant women in South Africa (median UIC of 176.8 μg/l), which reported adequate iodine nutrition. 17 In Cambodia, Karakochuk et al 20 also found adequate iodine status in pregnant women. The results of our study, however, showed that there was variation in median UICs when measured in different trimesters.…”

Section: Tsh Levels Of Pregnant Womenmentioning

confidence: 95%

Iodine status of pregnant women and children age 6 to 12 years feeding from the same food basket in Mopani district, Limpopo province, South Africa

Mabasa

Mabapa

Jooste

et al. 2018

South African Journal of Clinical Nutrition

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The aim of the study was to assess the iodine status of pregnant women and children age 6 to 12 years feeding from the same food basket in Mopani District. Design: A cross-sectional study was conducted. Setting: The setting was primary health care clinics and households from five municipalities of Mopani District in Limpopo province. Subjects: A total of 565 conveniently selected pregnant women and 116 children aged 6 to 12 years were recruited, of which 116 were mother-child pairs. Methods: The demographic information, iodine nutrition knowledge and salt consumption patterns were obtained using a validated questionnaire. Spot urine, household drinking water and salt samples were collected and analysed for iodine using standard procedures. A professional nurse, using filter paper to determine thyroid stimulating hormone (TSH) levels, collected spot finger-stick blood samples from pregnant women. Results: The findings showed that only 52.5% of household salt had an iodine concentration level of more than and equal to 15 ppm. The median iodine concentration of household drinking water was 46.2 μg/l (interquartile range [IQR] 10.8-73.4 μg/l). The TSH levels of the majority of pregnant women were normal and the maternal overall median urinary iodine concentration (UIC) was 164 μg/l (IQR 92-291 μg/l), indicating maternal iodine sufficiency. However, median UIC in the first and third trimesters was below 150 μg/l, indicating iodine insufficiency. The UIC level of children in the study was 386 μg/l (IQR 200-525 μg/l), signifying iodine excess. Conclusion:Iodine status of pregnant women in this study was sufficient, with UIC for children excessively high, more than two times higher than the iodine status of pregnant women. The reasons for the excessive UIC in school-age children need to be elucidated.

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Section: Tsh Levels Of Pregnant Womenmentioning

confidence: 95%

Iodine status of pregnant women and children age 6 to 12 years feeding from the same food basket in Mopani district, Limpopo province, South Africa

Mabasa

Mabapa

Jooste

et al. 2018

South African Journal of Clinical Nutrition

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“…In school-age children and non-lactating or non-pregnant women, a median UIC range of 100-299 μg/L shows that iodine deficiency does not occur in a population with any more than 50% of urine samples below 100 μg/L and not more than 20% of samples should have an iodine concentration below 50 μg/L [26][27][28]. Kismantoro and Slogohimo sub-districts, Wonogiri Regency has no iodine deficiency, 10% of urine samples in of childbearing ages 100 μg/L and 2.9% of urine samples below 50 μg/L (Table 1).…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Iodine Status and Thyroid Stimulating Hormone (TSH) and Free T4 (FT4) in Women of Childbearing Age in Wonogiri Regency

Hidayat¹,

Musoddaq²,

Ashar³

et al. 2023

Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)

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The urinary iodine concentration (UIC) is the most common indicator for assessing the population's iodine status. Urinary iodine does not provide information about thyroid function directly. However, iodine status is an important determinant of thyroid disorders in women of childbearing age. This study aimed to know the relationship between iodine status and thyroid function using indicators of stimulating thyroid hormone (TSH) and free T4 (FT4) levels in women of childbearing age in Wonogiri Regency. A community-based cross-sectional study was conducted in Kismantoro and Slogohimo sub-districts, Wonogiri Regency. A simple random sampling procedure was used to select the study participants. A total of 170 women aged 15-49 years were assessed for UIC, and serum TSH and FT4 levels. The ammonium persulfate digestion method measured urinary iodine concentration (UIC). Serum TSH and FT4 levels by enzyme-linked immunosorbent assay (ELISA). Variables with nominal scales were presented as frequencies and percentages. Correlation analysis was done to find an association between variables. A p-value < 0.05 was considered significant with a CI of 95%. The median UIC was 247.45 μg/L (232.5-1004), indicative of more than adequate. The mean TSH (2.04 ± 2.24 μIU/ml) and FT4 (1.31 ± 0.30 ng/dl) concentrations were within normal reference ranges. The UIC no significantly correlated with serum TSH p = 0.664 (p > 0.05), FT4 p = 0.845 (p > 0.05) levels and thyroid functions p = 1.000 (p > 0.05). Finally, iodine intakes assessed by UIC in our study of women of childbearing age were regarded as sufficient in Wonogiri Regency, and no correlation was found between UIC and thyroid function test.

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“…In some iodine excess areas, the median UIC of more than 1000 μg/L has been reported [23]. Similarly, a review article on Cambodian school‐aged children's iodine status showed median UIC levels between 200 and 299 μg/L, indicating more than adequate iodine status [24]. Another Chinese study reported iodine excess with a median UIC of 750.18 μg/L [3].…”

Section: Discussionmentioning

confidence: 99%

Excessive iodine status among school‐aged children in the State of Qatar: Results of the National Iodine Deficiency Disorder Survey

Al-Thani

Alyafei

Al‐Motawaa

et al. 2023

Public Health Challenges

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Background: Iodine deficiency poses a significant public health challenge worldwide, particularly in preschool children and pregnant women. Assessing the iodine intake at a population level is essential, as both deficient and excessive iodine status can have adverse health consequences. The main objective of this survey is to understand the iodine deficiency status in schoolchildren aged 6-12 years in the State of Qatar. Methods: A cross-sectional survey was conducted from March to June 2014 among school-aged children using a two-stage cluster sampling technique. Anthropometric, biochemical, clinical, and dietary parameters for seafood were collected. Spot urine samples were collected from 967 participants, and a repeat random subsample urine was collected from 288 participants. Overall median urinary iodine concentration (UIC) was calculated. Iodine content in household salt samples was estimated by qualitative and quantitative methods. Mann-Whitney U test was used for comparison. Results: The median UIC was 333.2 µg/L (IQR = 228.6). UIC prevalence rates between 300-999 and >1000 µg/L were 56.7% and 2.8%, respectively. The goiter prevalence was 0.4%. A significant difference was noted in overall median UIC levels between boys and girls (p = 0.003). Adequate iodized salt consumption was reported by 74.9% of households, and weekly seafood consumption was reported by one third of the respondents. Conclusion:The results indicate an excess intake of iodine among the studied population in the State of Qatar, and national efforts are needed to bring iodine intake and concentration levels within the cutoff value for the concerned survey population's age group. In addition, a surveillance system needs to be set up for continuous monitoring of iodine content and salt intake at the population level in the State of Qatar.

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Median Urinary Iodine Concentrations Are Indicative of Adequate Iodine Status among Women of Reproductive Age in Prey Veng, Cambodia

Cited by 6 publications

References 17 publications

Iodine status of pregnant women and children age 6 to 12 years feeding from the same food basket in Mopani district, Limpopo province, South Africa

Iodine status of pregnant women and children age 6 to 12 years feeding from the same food basket in Mopani district, Limpopo province, South Africa

The Relationship Between Iodine Status and Thyroid Stimulating Hormone (TSH) and Free T4 (FT4) in Women of Childbearing Age in Wonogiri Regency

Excessive iodine status among school‐aged children in the State of Qatar: Results of the National Iodine Deficiency Disorder Survey

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