Media and communication technologies

Goble, Mark

doi:10.1017/cbo9780511763311.023

Cited by 3 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IKDC evaluation of ROM revealed 13 patients having no change, two patients with loss of ROM (10-12"), and one patient gained 53" of flexion. No radiographic changes were found when comparing pre-and postoperative X-rays (20).…”

Section: Upmentioning

confidence: 77%

Meniscal substitutes – human experience

Goble¹,

Kohn

Verdonk

et al. 1999

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

A number of clinical series have described the effect of meniscus allograft replacement in humans. The general indication has been disabling pain following loss of a meniscus in a skeletally mature individual. Overall, healing of the graft to the capsule occurs in up to 80% of all transplants. Revascularization and cell repopulation is found in all grafts but is highly variable. The risk for graft failure seems to be greater with irradiated grafts and in patients with grade III or IV osteoarthritic changes. In most series, patients experienced a decrease in pain and an increase in activity level postoperatively. In many series, concominant surgery (cruciate ligament reconstruction or osteotomy) had been performed. Meniscus replacement with frozen or cryopreserved allografts seems to give the most promising short‐term results in patients with post‐meniscectomy pain. Controlled, randomized prospective studies are needed to confirm a long‐term benefit and better define transplantation indications. Viable meniscus allografts seem to survive transplantation, as donor cells were found in the graft after 2 years. Clinically, pain was reduced and activity increased following transplantation, but after 4 years some of these gains were lost. There was no correlation between postoperative findings on MRI and clinical outcome. Meniscal replacement with a quadriceps tendon autograft in humans resulted in pain reduction, but at second‐look arthroscopy, only 2 of 9 tendon autografts looked like a meniscus. Six were in position but still looked like tendons. Total medial meniscus replacement by quadriceps tendon autrograft is still an experimental procedure. There is no proof at present that meniscal substitutes (meniscus allografts or tendon autografts) in humans can protect the hyaline cartilage of the knee from the degeneration, following loss of a meniscus. There is some evidence in animal experiments that under circumstances not yet exactly known, a meniscus substitute can have a protective effect on articular cartilage. Three factors have been identified that prevent proper meniscal function: poor fixation of the meniscal horns, no contact of the graft with the articulating surfaces under load and incorrect positioning of the horns. Meniscal allograft transplantation sensitizes humoral and cell mediated immune systems. Bone plugs attached to meniscal allograft tissue may increase cell surface antigenicity. Deep freezing and especially freeze drying of meniscal tissue decreases host immunogenicity. Cryopreservation maintains the content of donor HLA encoded antigens and is likely more sensitizing to the host. The clinical importance of immune responses to meniscal allografts is not known, but it has not been shown to result in graft failure or rejection. Prospective studies are needed.

show abstract

Section: Upmentioning

confidence: 77%

Meniscal substitutes – human experience

Goble¹,

Kohn

Verdonk

et al. 1999

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

show abstract

“…These and other aspects of the role of the host a s the most variable factor in this host-parasite relationship have not yet been fully expressed, although the importance of some host effects has been implied. For example, there is the association of post-kala azar dermal leishmaniasis with treatment (Brahmachari, 1942) and the association of the severity of infection and other manifestations with body temperature (Stauber, 1962) and with the nutritional (Corkill, 1949;Actor, 1960), immunological (Cahill, 1964, and others) and endocrinological (Goble, 1965) state of the host.…”

mentioning

confidence: 99%

DIVISION OF MICROBIOLOGY: THE ORIGIN AND SIGNIFICANCE OF THE DISTRIBUTION OF PARASITES IN VISCERAL LEISHMANIASIS

Stauber

1966

Trans NY Acad Sci

View full text Add to dashboard Cite

On reading the literature describing the histopathology of visceral leishmaniasis in man and animals, one is struck not only by the heavy involvement of spleen, liver, and bone marrow (Christophers, 1904; Shortt, 1923-24; Meleney, 1925) but by the diversity of the other organs in which leishmania may be found in focal o r extensive lesions. A representative sample would be small intestine (Perry, 1922), facial mucocutaneous a r e a s (Kirk, 1942), vaginal mucosa (Symmers, 1960), larynx (Sati, 1962, testis, prostate, meninges and lungs. A late reference to this varied distribution is Manson-Bahr's statement (1959) that in man "leishmania can b e found in any organ, the blood or the skin." With such diversity, it would be expected that the variability from patient to patient o r animal to animal would be considerable.In contrast to this a r e the findings using intracardially (IC) infected golden hamsters, where organs other than the spleen, liver, and bone marrow a r e less frequently involved, even though infected lymphoid cells may b e observed in blood smears late in the infections.Laveran (1917) made an important pertinent observation, stating that the extent to which organs other than the spleen, liver, and bone marrow a r e involved in kala azar is determined by the intensity and duration of the infection.The intracardial route of infection leads to earlier death in the golden hamster through visceral leishmaniasis (Stauber, 1955), a s contrasted with natural o r experimentally induced infections in man and some other animals. For example, one Chinese hamster was not necropsied until 455 days after inoculation (Meleney, 1925), whereas deaths as early as 28 days have been seen in the golden hamster when infected intracardially. Time may be an important variable in the distribution of lesions under such conditions.The parasites themselves may be another such variable. Even for those designated Leishmmia donouaizi, various isolates show different properties upon close examination. Morphological and cultural traits have not been very helpful in these distinctions. Adler (1963), however, has recently made prog r e s s using serological techniques, and others have found iiz uivo strain differences (Goodwin, 1945;Stauber, 1966) which a r e probably more pertinent to the present discussion. Still, there is no evidence yet that these strains result in host organ localizations of a specific nature. From the wide variety of clinical manifestations in the cases of kala azar reported for man, and especially from East Africa where an especially wide range of these variations occurs involvingboth skin and viscera, the parasites 635

show abstract

Radio with pictures: Radio visualization in BBC national radio

Berry

2013

Radio Journal:International Studies in Broadcast &Amp; Audio Media

View full text Add to dashboard Cite

Abstract.Radio has always had pictures. The ones the listener created in their own minds and this is, most of us agree, one of the medium's greatest strengths. However, radio is increasingly consumed on a digital platform (such as DAB Radio, Digital TV, a mobile device or a computer) on devices with screens, rather than a dial. This creates a problem for radio because when we look at the device we are listening to we see a screen that often lacks rich content. The process of Radio Visualisation is about filling this space. This papers focus, though, is the other ways in which radio is visualising itself online in a process that deploys transmedia storytelling techniques that build relationships with the audience, builds brands and helps broadcasters to tell stories in ways never before possible.

show abstract

Media and communication technologies

Cited by 3 publications

References 3 publications

Meniscal substitutes – human experience

Meniscal substitutes – human experience

DIVISION OF MICROBIOLOGY: THE ORIGIN AND SIGNIFICANCE OF THE DISTRIBUTION OF PARASITES IN VISCERAL LEISHMANIASIS

Radio with pictures: Radio visualization in BBC national radio

Contact Info

Product

Resources

About