Meconium microbiota predicts clinical early-onset neonatal sepsis in preterm neonates

Dornelles, Laura Vargas; Procianoy, Renato S.; Roesch, Luiz Fernando Würdig; Corso, Andrea; Dobbler, Priscila Caroline Thiago; Mai, Volker; Silveira, Rita de Cássia dos Santos

doi:10.1080/14767058.2020.1774870

Cited by 13 publications

(9 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The meconium microbiome has been discussed as a potential source of information about long term health and disease (13). Recent evidence demonstrates that the meconium microbiome may predict and impact health and disease both early in life, in terms of weight gain and growth (17), sepsis risk (24), and NEC propensity (25), as well as later in life, e.g., concerning the incidence of asthma, allergies, obesity and psychiatric illnesses (26). A comprehensive understanding of baseline bacterial structure and composition of meconium may complement our knowledge in this respect.…”

Section: Discussionmentioning

confidence: 99%

Meconium Microbiome of Very Preterm Infants across Germany

Klopp

Ferretti

Meyer

et al. 2022

mSphere

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Meconium Microbiome of Very Preterm Infants across Germany

Klopp

Ferretti

Meyer

et al. 2022

mSphere

View full text Add to dashboard Cite

show abstract

“…They observed that the abundance of Pelomonas puraquae bacteria from the Proteobacteria phylum was high in 43 meconium samples. Dornelles et al (2020) evaluated the microbiota of the meconium of 84 premature babies younger than 32 weeks of gestation, of which 40 were diagnosed with early onset neonatal sepsis and 44 were not diagnosed. The most abundant phylum in both the groups was Proteobacteria .…”

Section: Discussionmentioning

confidence: 99%

Effect of Feeding Fresh or Frozen Breast Milk on the Gut Microbiota of Premature Infants: A Prospective Observational Study

Merter,

Altay

2023

Biological Research For Nursing

View full text Add to dashboard Cite

Background Breast milk is essential for premature infants. It contains a variety of functional and protective nutrients that help to create a suitable microenvironment for intestinal development and maturation. This prospective and observational study was planned to examine the effects of feeding premature infants with fresh or frozen breastmilk on their gut microbiota. Materials and Methods The study was carried out with a total of 40 infants, with a gestational age of 28–326 weeks, fed fresh ( n = 20) or frozen ( n = 20) breastmilk. Stool samples were stored at −80°C until analysis. Infants were included in groups based on the feed type, which accounted for more than 70% of their 10-day feeding. The Mann-Whitney U, Chi-square, and t-tests were used to evaluate the demographic data. Stool samples were analyzed by sequencing the V3–-V4 region of the 16S rRNA gene from the extracted DNA for microbiota analysis. Results Streptococcus and Enterobacteriales, the majority of which are considered human pathogens, in infants receiving frozen breastmilk ( Streptococcus 69%, Enterobacteriales 79%) was higher than that in infants receiving fresh breastmilk ( Streptococcus 16%, Enterobacteriales 49%). Further, the Lactobacillus and Bifidobacterium species were more abundant in infants who received fresh breastmilk ( Lactobacillus 17%, Bifidobacterium 12%) than in infants who received frozen breastmilk ( Lactobacillus 3%, Bifidobacterium 1%). Conclusion Thus, compared to frozen breast milk, fresh breastmilk has an effect on the diversity of preterm infants’ gut microbiota.

show abstract

“…25 Other species of Paenibacillus have been identified in the soil globally [26][27][28][29][30] and as a member of the human gut microbiome. 31 Some species are known to infect honeybees 32 and, rarely, humans. [33][34][35] Neonates cared for in industrialized or high-resource settings may have limited contact with environmental reservoirs of Paenibacillus.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Paenibacilliosis:Paenibacillus thiaminolyticusas a Novel Cause of Neonatal Sepsis with High Risk of Sequelae in Uganda

Ericson

Burgoine

Kumbakumba

et al. 2022

Preprint

View full text Add to dashboard Cite

Paenibacillus thiaminolyticus may be an underdiagnosed cause of neonatal sepsis. We prospectively enrolled 800 neonates presenting with a clinical diagnosis of sepsis at two Ugandan hospitals. Quantitative polymerase chain reaction specific to P. thiaminolyticus and to the Paenibacillus genus were performed on the blood and cerebrospinal fluid (CSF) of 631 neonates who had both specimen types available. Neonates with virus detected in either specimen type were considered to potentially have paenibacilliosis. We described antenatal, perinatal, and neonatal characteristics, presenting signs, and 12-month developmental outcomes for neonates with paenibacillosis vs. clinical sepsis. Median age at presentation was 3 (interquartile range 1, 7) days. Fever (92%), irritability (84%) and seizures (51%) were common. Eleven (30%) had an adverse outcome: 5 (14%) neonates died during the first year of life; 5 of 32 (16%) survivors developed postinfectious hydrocephalus and one (3%) additional survivor had neurodevelopmental impairment without hydrocephalus. These results highlight the need to consider local pathogen prevalence and the possibility of unusual pathogens when determining antibiotic choice for neonatal sepsis.

show abstract

Meconium microbiota predicts clinical early-onset neonatal sepsis in preterm neonates

Cited by 13 publications

References 35 publications

Meconium Microbiome of Very Preterm Infants across Germany

Meconium Microbiome of Very Preterm Infants across Germany

Effect of Feeding Fresh or Frozen Breast Milk on the Gut Microbiota of Premature Infants: A Prospective Observational Study

Neonatal Paenibacilliosis:Paenibacillus thiaminolyticusas a Novel Cause of Neonatal Sepsis with High Risk of Sequelae in Uganda

Contact Info

Product

Resources

About