Mecobalamin and early functional outcomes of ischemic stroke patients with H-type hypertension

Yuan, Meini; Wang, Beiyun; Tan, Shijin

doi:10.1590/1806-9282.64.05.428

Cited by 8 publications

(7 citation statements)

References 22 publications

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“…Literature has proved that Cerebellar molecular cell layer`injury by lithium 13 is reversible and these findings are in agreement with Netto and Phutane 14 . .…”

Section: Discussionsupporting

confidence: 87%

Ameliorarting Action of Methylcaobalamin on Degenerated Cerebellar Molecular Cell Layer

Kohari¹,

Amjad²,

Malick³

2021

PJMHS

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Background: Cerebellum the hindbrain is located in the posterior cranial fossa.The cerebellar cortex consists, of a gray matter and a white matter and the gray matter comprises of outer molecular layer, middle purkinje cell layer and inner most is the granule cell layer. The antimaniac drug lithium caused distortion to the outer molecular cell layer which was repaired and the damage was lessened by injecting the albino rats with Methylcobalamin. Aim: To observe and document the data of the restored thickness of molecular cell layer after Methylcobalamin administration. Methods: Eighteen albino rats were selected and were treated with lithium and Methylcobalamin for a period of 4 weeks. Results: The results showed regeneration and improved thickness of molecular cell layer stressing the need for educating our masses in dietary use of vitamin b12 and the consultants to prescribe Methylcobalamin in neuronal injuries. Conclusion: My study proved that the use of vitamin b12 is mandatory in strengthening and restoring the cerebellar molecular gray matter. Keywords: Cerebellar molecular cell layer,Degeneration, Regeneration

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“…Literature has proved that Cerebellar molecular cell layer`injury by lithium 13 is reversible and these findings are in agreement with Netto and Phutane 14 . .…”

Section: Discussionsupporting

confidence: 87%

Ameliorarting Action of Methylcaobalamin on Degenerated Cerebellar Molecular Cell Layer

Kohari¹,

Amjad²,

Malick³

2021

PJMHS

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“…CRP is elevated in hypertensive patients, being one of the determinants of systemic inflammation caused by AH [43]. Furthermore, periodontitis increases the levels of local and systemic inflammatory markers, in addition to causing changes in the neutrophil function.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Non-surgical Periodontal Treatment on Patients With Combined Refractory Arterial Hypertension and Stage Iii, Grade B Periodontitis: A Preliminary Prospective Clinical Study

Rodrigues¹,

Cláudio²,

Franciscon³

et al. 2023

Preprint

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We sought to evaluate the effects of non-surgical periodontal treatment (NSPT) on periodontal clinical parameters, systemic blood pressure (BP) and plasma levels of systemic inflammation markers in patients with combined refractory arterial hypertension (RAH) and stage III grade B periodontitis. Twenty-seven participants with RAH and periodontitis received NSPT. The analyzed clinical parameters were probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and plaque index (PI). An assessment was performed for systemic BP, complete blood count, coagulogram, creatinine measurement, C-reactive protein (CRP), glycated hemoglobin, cholesterol, glutamic oxaloacetic transaminase, glutamate pyruvic transaminase, waist-hip ratio, and body mass index. In the follow-up period, twenty-two patients were evaluated at baseline and after 90 and 180 days. The data were submitted to statistical analysis (α=0.05%). As expected, the clinical results showed a significant improvement in the percentages of PI, BOP, PD and CAL, which were statistically significant at 90 and 180 days (p&lt;0.0001). Importantly, NSPT significantly reduced the blood level of CRP (p&lt;0.02). However, no significant reduction in BP parameters was noted in the evaluated follow-up periods. NSPT, despite the benefits in periodontal clinical parameters, reduced the plasma level of CRP but not the BP in patients with combined RAH and periodontitis.

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“…Yuan et al selected 224 cases of ischemic stroke and H type hypertension and randomly divided them into two groups with and without treatment of mecobalamin to analyze the effect of mecobalamin on the early-functional outcomes of patients with ischemic stroke and H type hypertension. The results showed that mecobalamin could reduce the level of plasma Hcy, resulting in a more significant functional recovery [ 48 ]. Another investigation suggested that the folate and vitamin B-12 levels were lower among those with the TT gene type compared with those with the CC/CT gene type and indicated that those with the TT genotype may have both folate and vitamin B-12 insufficiencies as well as decreased MTHFR enzyme activity [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

The prevalence, relative risk factors and MTHFR C677T genotype of H type hypertension of the elderly hypertensives in Shanghai, China: a cross-section study

Qian

Cao

Zhang

et al. 2021

BMC Cardiovasc Disord

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Background H type hypertension is defined as homocysteine (Hcy) ≥ 10 μmol/L in combination with primary hypertension. Studies demonstrated that the existence of hyperhomocysteine (HHcy) in hypertensive exacerbates the poor outcome of cardiocerebral incidents. This study was to investigate the current epidemic situation of H type hypertension and determine the risk factors in order to find intervention targets for H type hypertensives. Methods We conducted a cross-sectional study using cluster sampling design in Shanghai, China from July 2019 and April 2020. 23,652 patients with primary hypertension were enrolled in this study. Their medical information was recorded, and the level of Hcy concentrations and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms were detected. Results In total, 22,731 of 23,652 patients were recorded. The mean age was 68.9 ± 8.6 y and 43% were men. 80.0% of the enrolled patients had H type hypertension. The frequency of allele T was 40.9%, and the proportions of the CC, CT, and TT genotypes were 36.1%, 46.0%, and 17.9%, respectively. Compared with the TT genotype, the plasma Hcy concentration levels were lower in patients with the CC/CT genotype (18.96 ± 13.48 μmol/L vs. 13.62 ± 5.20/14.28 ± 5.36, F = 75.04, p < 0.01). The risk for H type hypertension was higher in elderly people. Men had ~ 5.55-fold odds of H type hypertension compared with women. Patients with CT genotype and TT genotype had ~ 1.36- and ~ 2.76-fold odds of H type hypertension compared with those with CC genotype, respectively. Smoking and diabetes were not significantly associated with H type hypertension. Conclusions The prevalence of H type hypertension in patients with primary hypertension was 80.0%, which was higher than the 75% found in prior report in China. Age, gender, and MTHFR C677T polymorphisms rather than smoking and diabetes were independently associated with H type hypertension.

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Mecobalamin and early functional outcomes of ischemic stroke patients with H-type hypertension

Cited by 8 publications

References 22 publications

Ameliorarting Action of Methylcaobalamin on Degenerated Cerebellar Molecular Cell Layer

Ameliorarting Action of Methylcaobalamin on Degenerated Cerebellar Molecular Cell Layer

The Effect of Non-surgical Periodontal Treatment on Patients With Combined Refractory Arterial Hypertension and Stage Iii, Grade B Periodontitis: A Preliminary Prospective Clinical Study

The prevalence, relative risk factors and MTHFR C677T genotype of H type hypertension of the elderly hypertensives in Shanghai, China: a cross-section study

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