2018
DOI: 10.1590/1806-9282.64.05.428
|View full text |Cite
|
Sign up to set email alerts
|

Mecobalamin and early functional outcomes of ischemic stroke patients with H-type hypertension

Abstract: SUMMARY OBJECTIVE To analyze the effect of mecobalamin on the early-functional outcomes of patients with ischemic stroke and H-type hypertension. METHODS From October of 2014 to October of 2016, 224 cases of ischemic stroke and H-type hypertension were selected. The patients were randomly divided into treatment control groups, with 112 patients in each group. The control group was treated with the conventional therapy. The observation group was treated with 500 µg of mecobalamin three times a day in additi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

1
3
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 6 publications
(4 citation statements)
references
References 22 publications
(11 reference statements)
1
3
0
Order By: Relevance
“…Literature has proved that Cerebellar molecular cell layer`injury by lithium 13 is reversible and these findings are in agreement with Netto and Phutane 14 . .…”
Section: Discussionsupporting
confidence: 87%
“…Literature has proved that Cerebellar molecular cell layer`injury by lithium 13 is reversible and these findings are in agreement with Netto and Phutane 14 . .…”
Section: Discussionsupporting
confidence: 87%
“…Yuan et al selected 224 cases of ischemic stroke and H type hypertension and randomly divided them into two groups with and without treatment of mecobalamin to analyze the effect of mecobalamin on the early-functional outcomes of patients with ischemic stroke and H type hypertension. The results showed that mecobalamin could reduce the level of plasma Hcy, resulting in a more significant functional recovery [ 48 ]. Another investigation suggested that the folate and vitamin B-12 levels were lower among those with the TT gene type compared with those with the CC/CT gene type and indicated that those with the TT genotype may have both folate and vitamin B-12 insufficiencies as well as decreased MTHFR enzyme activity [ 25 ].…”
Section: Discussionmentioning
confidence: 99%
“…It was documented attenuating vincrinstine‐induced painful peripheral neuropathy, probably through inhibition of NF‐κB pathway activation as well as alternations of the pro‐inflammatory and anti‐inflammatory cytokine levels in spinal dorsal 27 . In a randomized controlled trial of ischemic stroke, MeCbl treatment also contributed to the decrease in carotid artery plaques volume, accompanied by reduced plasma inflammatory factor levels 28 . Moreover, inorganic As underwent enzymatic methylation after entering the body, which seized bioactive methyl in the body and consequently, resulted in genome wide methylation change 29 and the modified methylation profile was associated with the susceptibility to As adverse health effects 30,31 .…”
Section: Introductionmentioning
confidence: 99%
“…27 In a randomized controlled trial of ischemic stroke, MeCbl treatment also contributed to the decrease in carotid artery plaques volume, accompanied by reduced plasma inflammatory factor levels. 28 Moreover, inorganic As underwent enzymatic methylation after entering the body, which seized bioactive methyl in the body and consequently, resulted in genome wide methylation change 29 and the modified methylation profile was associated with the susceptibility to As adverse health effects. 30,31 MeCbl acts as an important cofactor in the activities of B12-dependent methyltransferases and plays a positive role in gene methylation process via supplying methyl group in various kind of organisms.…”
mentioning
confidence: 99%