Background: Cerebellum the hindbrain is located in the posterior cranial fossa.The cerebellar cortex consists, of a gray matter and a white matter and the gray matter comprises of outer molecular layer, middle purkinje cell layer and inner most is the granule cell layer. The antimaniac drug lithium caused distortion to the outer molecular cell layer which was repaired and the damage was lessened by injecting the albino rats with Methylcobalamin. Aim: To observe and document the data of the restored thickness of molecular cell layer after Methylcobalamin administration. Methods: Eighteen albino rats were selected and were treated with lithium and Methylcobalamin for a period of 4 weeks. Results: The results showed regeneration and improved thickness of molecular cell layer stressing the need for educating our masses in dietary use of vitamin b12 and the consultants to prescribe Methylcobalamin in neuronal injuries. Conclusion: My study proved that the use of vitamin b12 is mandatory in strengthening and restoring the cerebellar molecular gray matter. Keywords: Cerebellar molecular cell layer,Degeneration, Regeneration
Background: Cerebellar cortexconsists of three layers. The outer molecular, middlePurkinje cell layer, inner granule cell layer. Lithium the alkali metal hasdeleterious effects on nervous tissue and this study proved the injurious effects of lithium on molecular cell layer of cerebellum. Aim: To observe and report the damaging histological and morphological change of the decrement in the thickness of cerebellar molecular layer by Lithium. Methods: This study was designed to observe the microscopic changes of thickness of molecular layer in rat cerebellum. For this experimental study 12 animals were used, they were divided into two groups, each comprising of 6 animals. Results: Group-A received normal lab diet and water ad libitum while group B received injectable lithium carbonate 20 mg/kg/ for 4 weeksrespectively. Micrometry was done and changes of the thickness of molecular cell layer were recorded and documented. Conclusion: The pernicious effects of Lithium Carbonate on molecular cerebellar cortex were visualized and evaluated .Highly significantly decreased changes of thickness of molecular cell layer were documented in rat cerebellum. Keywords: Lipidperoxidation,Molecular cell layeratrophy, decomposition
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