Mechanotransduction Pathways Linking the Extracellular Matrix to the Nucleus

Jahed, Zeinab; Shams, Hengameh; Mehrbod, Mehrdad; Mofrad, Mohammad R. K.

doi:10.1016/b978-0-12-800180-6.00005-0

Cited by 101 publications

(95 citation statements)

References 209 publications

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“…Consequently, responses of cells to all other nanostructures can be assessed on the same platform, upon disturbing various regulators of nanostructure sensing with the delivered biological effectors. Combining various cell-nanopillar interactions on a single platform with methods presented here will allow the direct assessment of different cell sensing, adhesion and mechanotrandsuction mechanisms [26] upon cell transfection with effectors tethered to membranepenetrating nanopillars.…”

Section: Discussionmentioning

confidence: 99%

Cell responses to metallic nanostructure arrays with complex geometries

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Cell responses to metallic nanostructure arrays with complex geometries

et al. 2014

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“…To understand valvular disease, we need to understand the mechanisms through which external factors/signals influence the biological response of the valvular cells and their consequent mechanotransduction signals that are transduced to the underlying proteins. 71,113 These in turn lead to conformational changes in individual proteins that elicit biological responses reflected in the valve disease.…”

Section: Disease Specific Modelingmentioning

confidence: 99%

Emerging Trends in Heart Valve Engineering: Part IV. Computational Modeling and Experimental Studies

et al. 2015

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Abstract-In this final portion of an extensive review of heart valve engineering, we focus on the computational methods and experimental studies related to heart valves. The discussion begins with a thorough review of computational modeling and the governing equations of fluid and structural interaction. We then move onto multiscale and disease specific modeling. Finally, advanced methods related to in vitro testing of the heart valves are reviewed. This section of the review series is intended to illustrate application of computational methods and experimental studies and their interrelation for studying heart valves.

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“…1,14,17 First identified in 2005 by Crisp et al, the LINC complex consists of a series of proteins containing KASH-domain and SUN-domain proteins, which reside in the outer and inner nuclear membranes, respectively. 7,18 This evolutionarily conserved molecular bridge is known to transmit spatial, structural and mechanical information across from the cytoskeleton to the nucleoskeleton.…”

Section: Nuclear-cytoskeletal Coupling Via the Linc Complex And Nuclementioning

confidence: 99%