Mechanoresponsive and lubricating changes of mandibular condylar cartilage associated with mandibular lateral shift and recovery in the growing rat

Wu, Yang; Podyma‐Inoue, Katarzyna Α.; Yonemitsu, Ikuo; Watari, Ippei; Ikeda, Yuhei; Guo, Xiyuan; Watabe, Tetsuro; Ono, Takashi

doi:10.1007/s00784-020-03225-4

Cited by 5 publications

(10 citation statements)

References 41 publications

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“…Previous studies showed that mandibular lateral shift affected TMJ mechanoreceptors, altered biomolecules involved in hyaluronic acid metabolism and the expression of IGF1 and FGF2 and their receptors, and disturbed the oxidative stress/nitric oxide balance. 13,[41][42][43] We explored the effect of mandibular deviation on the histological morphology of the TMJ, condylar cartilage, ECM, and subchondral bone from 3 days to 8 weeks, which has not been performed previously. The TMJ OA-like lesions found in our results indicate that the experimental rat model of lateral mandibular shift can also be a good candidate for a TMJ OA model.…”

Section: Discussionmentioning

confidence: 99%

“…The dynamic balance between the internal and external environments of the TMJ cavity is an important prerequisite for its health. Previous studies showed that mandibular lateral shift affected TMJ mechanoreceptors, altered biomolecules involved in hyaluronic acid metabolism and the expression of IGF1 and FGF2 and their receptors, and disturbed the oxidative stress/nitric oxide balance 13,41–43 . We explored the effect of mandibular deviation on the histological morphology of the TMJ, condylar cartilage, ECM, and subchondral bone from 3 days to 8 weeks, which has not been performed previously.…”

Section: Discussionmentioning

confidence: 99%

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Experimental functional shift–induced osteoarthritis‐like changes at the TMJ and altered integrin expression in a rat model

Zou

Cai

Lin

et al. 2022

Annals of the New York Academy of Sciences

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Mandibular deviation affects the biomechanical environment of the temporomandibular joint (TMJ) and causes thinning of cartilage on the deviated side. We aimed to evaluate, using a rat model, the effect of mandibular functional deviation on the TMJ in relation to the functional roles of integrin β family members. The effects of experimental functional deviation on the TMJ of 6-week-old Sprague-Dawley female rats, randomly assigned to control (n = 42) and experimental groups (n = 42), were evaluated at 3 days and 1, 2, 4, and 8 weeks by histological staining, immunofluorescence, real-time quantitative polymerase chain reaction, and micro-computed tomography. The results showed that the experimental functional shift changed the shape of condyles, thinned the cartilage, and increased the proportion of the hypertrophic layer on the deviated sides of condyles. In addition, the extracellular matrix of the condyle cartilage exhibited degradation at 1 week and subchondral trabecular bone was lost at 4 and 8 weeks. Osteoarthritis (OA)-like changes occurred in the left and right condyles of rats in the experimental group and were aggravated over time. Integrin β family expression, especially integrin β 2 , was altered from week 1, possibly related to the OA-like changes. These data may provide insight into the onset of TMJ OA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Experimental functional shift–induced osteoarthritis‐like changes at the TMJ and altered integrin expression in a rat model

Zou

Cai

Lin

et al. 2022

Annals of the New York Academy of Sciences

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“…In this study, an appliance was designed to induce FMLS in growing rats by enabling the mandible to laterally deviate at an optical distance of approximately 2 mm, which has been verified in other studies regarding its effectiveness [23,[26][27][28][29]. The FMLS appliance can be stably maintained for a considerable period (≥4 weeks) and harmlessly withdrawn to allow tissue recovery.…”

Section: Discussionmentioning

confidence: 70%

“…Animal experiments have shown that lateral mandibular deviation induces morphological changes in the mandible and temporomandibular joint (TMJ), as well as substantial variations in cellular signaling [ 21 , 22 , 23 , 24 ]. A mandibular lateral shift can cause asymmetry regarding the location and size of the bilateral glenoid fossae in growing rats [ 21 ] and a propensity for dysfunctional remodeling of the ipsilateral condyle [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…A mandibular lateral shift can cause asymmetry regarding the location and size of the bilateral glenoid fossae in growing rats [ 21 ] and a propensity for dysfunctional remodeling of the ipsilateral condyle [ 22 ]. In addition, a thickened superficial layer of condylar cartilage, which is indicative of adaptive alterations in the TMJ, has been reported upon inducing FMLS in growing rats [ 23 ]. Further, a mandibular lateral shift can increase the expression of neuronal nitric oxide synthase and vascular endothelial growth factor in the MM, causing altered superoxide dismutase activity [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Reversible Effects of Functional Mandibular Lateral Shift on Masticatory Muscles in Growing Rats

et al. 2023

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In this study, we aimed to determine the effects of functional mandibular lateral shift (FMLS) on the muscle mass, fiber size, myosin heavy chain fiber type, and related gene expression in masticatory muscles (masseter and temporalis), as well as whether the baseline levels could be recovered after FMLS correction in growing rats. The FMLS appliance was placed to shift the mandible leftward by approximately 2 mm. After FMLS placement for 2 and 4 weeks, the muscles on the left side had significantly lower wet weight, mean cross-sectional area, and proportion of type IIa fibers than those on the right side or in the control groups (p < 0.05), with downregulation and upregulation of IGF-1 and GDF-8 gene expression, respectively (p < 0.05). Following 2 weeks devoted to recovery from FMLS, the muscle parameters in the recovery group were not significantly different to those of the control group, and IGF-1 expression in the left-side muscles was enhanced and GDF-8 expression was simultaneously suppressed. These findings indicate that the masticatory muscle changes induced via FMLS tend to revert to normal conditions if the intervention is eliminated at an early stage. Therefore, appropriate orthodontic treatment for FMLS during the growth period is advisable to prevent asymmetric alterations in masticatory muscles.

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The dynamic progression of temporomandibular joint osteoarthritis-like lesions elicited by mandibular shift in a rat model

Zou,

Huang,

Lin

et al. 2024

Annals of Anatomy - Anatomischer Anzeiger

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Mechanoresponsive and lubricating changes of mandibular condylar cartilage associated with mandibular lateral shift and recovery in the growing rat

Cited by 5 publications

References 41 publications

Experimental functional shift–induced osteoarthritis‐like changes at the TMJ and altered integrin expression in a rat model

Experimental functional shift–induced osteoarthritis‐like changes at the TMJ and altered integrin expression in a rat model

Reversible Effects of Functional Mandibular Lateral Shift on Masticatory Muscles in Growing Rats

The dynamic progression of temporomandibular joint osteoarthritis-like lesions elicited by mandibular shift in a rat model

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