Mechanophysiological analysis of anorectal function using simulated feces in human subjects

Sun, Dihua; Liao, Donghua; Chen, Ssu-Chi; Wong, Carlos K. H.; Leung, Wing Wah; Futaba, Kaori; Mak, Terrence; Ng, Simon; Gregersen, Hans

doi:10.1016/j.jare.2020.07.002

Cited by 14 publications

(29 citation statements)

References 31 publications

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“…As mentioned above, Fecobionics measures bag dimensions and pressure. Therefore, tension and deformation can be assessed, which is useful for analysis of sensory responses [ 7 , 11 , 24 , 38 ].…”

Section: Design Considerations For Fecobionics and Principle Of Mementioning

confidence: 99%

“…Fecobionics is a simulated stool capable of dynamic measurements in the lower GI tract [ 6 , 7 , 8 , 9 , 10 , 11 ]. It was originally developed to simulate the defecation process where it integrates several current technologies in a single examination.…”

Section: Design Considerations For Fecobionics and Principle Of Mementioning

confidence: 99%

“…Specifically, combining the geometric simulation with the force and deformation computations will provide better understanding of the defecatory process. Novel parameters such as frictional force and dynamic viscosity computations can be implemented in models of defecation [ 10 , 11 ].…”

Section: Advanced Analysis and Modelingmentioning

confidence: 99%

“…Within the past years a simulated stool named Fecobionics with the shape and properties of normal stool was developed [ 6 , 7 , 8 , 9 , 10 , 11 ]. Fecobionics records, in a single experiment, numerous parameters including pressures, bending, and shape changes during colonic transport and defecation of the device.…”

Section: Introductionmentioning

confidence: 99%

“…Novel analysis such as the rear-front pressure (preload-afterload) diagrams and quantification of defecation indices have been developed. Furthermore, papers have been published on modeling of Fecobionics data [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Novel Bionics Assessment of Anorectal Mechanosensory Physiology

Gregersen

2020

Bioengineering

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Biomechatronics (bionics) is an applied science that creates interdisciplinary bonds between biology and engineering. The lower gastrointestinal (GI) tract is difficult to study but has gained interest in recent decades from a bionics point of view. Ingestible capsules that record physiological variables during GI transit have been developed and used for detailed analysis of colon transit and motility. Recently, a simulated stool named Fecobionics was developed. It has the consistency and shape of normal stool. Fecobionics records a variety of parameters including pressures, bending, and shape changes. It has been used to study defecation patterns in large animals and humans, including patients with symptoms of obstructed defecation and fecal incontinence. Recently, it was applied in a canine colon model where it revealed patterns consistent with shallow waves originating from slow waves generated by the interstitial Cells of Cajal. Novel analysis such as the “rear-front” pressure diagram and quantification of defecation indices has been developed for Fecobionics. GI research has traditionally been based on experimental approaches. Mathematical modeling is a unique way to deal with the complexity. This paper describes the Fecobionics technology, related mechano-physiological modeling analyses, and outlines perspectives for future applications.

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Section: Design Considerations For Fecobionics and Principle Of Mementioning

confidence: 99%