2022
DOI: 10.1016/j.actbio.2022.07.042
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Mechanomodulatory biomaterials prospects in scar prevention and treatment

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Cited by 16 publications
(6 citation statements)
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“…125 Silicone can undergo a hydration reaction with the stratum corneum, and the treatment with silicone in wounds downregulates the expression of TGF-β1 and TGF-β2, thereby affecting fibrosis and collagen deposition, ultimately reducing scarring. 126 The results showed that the scar treated with silica gel sheet had PDGF and TGF-β1 are lower than the control group, and the scar area is significantly reduced, indicating that silica gel sheet may be a method to prevent scar formation. The expressions of PDGF and TGF-β1 in scar tissue treated with silicone for 4 months were lower than those in control, and the scar area was significantly 121 reduced, suggesting that silicone may be a method to prevent scar formation.…”
Section: Therapeutics Based On Mechanical Regulationmentioning
confidence: 91%
“…125 Silicone can undergo a hydration reaction with the stratum corneum, and the treatment with silicone in wounds downregulates the expression of TGF-β1 and TGF-β2, thereby affecting fibrosis and collagen deposition, ultimately reducing scarring. 126 The results showed that the scar treated with silica gel sheet had PDGF and TGF-β1 are lower than the control group, and the scar area is significantly reduced, indicating that silica gel sheet may be a method to prevent scar formation. The expressions of PDGF and TGF-β1 in scar tissue treated with silicone for 4 months were lower than those in control, and the scar area was significantly 121 reduced, suggesting that silicone may be a method to prevent scar formation.…”
Section: Therapeutics Based On Mechanical Regulationmentioning
confidence: 91%
“…The diagram illustrates the raised and elevated appearance of hypertrophic scars and keloids, along with the distinct composition of the ECM contributing to their abnormal growth. Reproduced with permission from ref . Copyright 2022 Elsevier.…”
Section: Introductionmentioning
confidence: 99%
“…11,12 The outcome of wound healing can vary, leading to different end points, such as scarless regeneration, normotrophic scars, hypertrophic scars, and keloids (Figure 1). 13 Considerable research indicates that wounds in early gestation fetal skin possess a remarkable ability to heal without leaving scars. The mechanisms underlying scarless fetal wound healing are intricate and not yet fully comprehended, involving various cell types and their activities.…”
Section: Introductionmentioning
confidence: 99%
“…It is well-known that mechanical environment plays an important role in tissue regeneration. After meshes are implanted, fibroblasts are recruited to the surface of the materials, fibroblasts differentiate into myofibroblasts, and deposit extracellular matrix (ECM) such as collagen to achieve wound repair after being stimulated by chemical or mechanical signals . Under normal circumstances, most myofibroblasts will gradually lead to apoptosis at the end of repair. , However, the abdominal wall is a tissue in constant dynamic motion and the mechanical stimulation provided to the cells is often too intense, which leads to excessive proliferation of myofibroblasts and deposition of excess ECM, resulting in scar tissue production. , These scar tissues encapsulate the mesh, making the tissue–mesh complex stiffer, which causes greater mechanical stimulation of the surrounding cells and tissues and allow further fibrosis to occur .…”
Section: Introductionmentioning
confidence: 99%