Mechanomodulatory biomaterials prospects in scar prevention and treatment

Fernandes, Maria G.; Silva, Lucília P. da; Cerqueira, Mariana T.; Ibanez, Rita I. R.; Murphy, Ciara M.; Reis, Rui L.; O’Brien, Fergal J.; Marques, Alexandra P.

doi:10.1016/j.actbio.2022.07.042

Cited by 18 publications

(12 citation statements)

References 94 publications

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“…125 Silicone can undergo a hydration reaction with the stratum corneum, and the treatment with silicone in wounds downregulates the expression of TGF-β1 and TGF-β2, thereby affecting fibrosis and collagen deposition, ultimately reducing scarring. 126 The results showed that the scar treated with silica gel sheet had PDGF and TGF-β1 are lower than the control group, and the scar area is significantly reduced, indicating that silica gel sheet may be a method to prevent scar formation. The expressions of PDGF and TGF-β1 in scar tissue treated with silicone for 4 months were lower than those in control, and the scar area was significantly 121 reduced, suggesting that silicone may be a method to prevent scar formation.…”

Section: Therapeutics Based On Mechanical Regulationmentioning

confidence: 91%

New insights into balancing wound healing and scarless skin repair

Zhou

Xie

et al. 2023

J Tissue Eng

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Scars caused by skin injuries after burns, wounds, abrasions and operations have serious physical and psychological effects on patients. In recent years, the research of scar free wound repair has been greatly expanded. However, understanding the complex mechanisms of wound healing, in which various cells, cytokines and mechanical force interact, is critical to developing a treatment that can achieve scarless wound healing. Therefore, this paper reviews the types of wounds, the mechanism of scar formation in the healing process, and the current research progress on the dual consideration of wound healing and scar prevention, and some strategies for the treatment of scar free wound repair.

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Section: Therapeutics Based On Mechanical Regulationmentioning

confidence: 91%

New insights into balancing wound healing and scarless skin repair

Zhou

Xie

et al. 2023

J Tissue Eng

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“…The diagram illustrates the raised and elevated appearance of hypertrophic scars and keloids, along with the distinct composition of the ECM contributing to their abnormal growth. Reproduced with permission from ref . Copyright 2022 Elsevier.…”

Section: Introductionmentioning

confidence: 99%

“…11,12 The outcome of wound healing can vary, leading to different end points, such as scarless regeneration, normotrophic scars, hypertrophic scars, and keloids (Figure 1). 13 Considerable research indicates that wounds in early gestation fetal skin possess a remarkable ability to heal without leaving scars. The mechanisms underlying scarless fetal wound healing are intricate and not yet fully comprehended, involving various cell types and their activities.…”

Section: Introductionmentioning

confidence: 99%

Revolutionizing Wound Healing: Exploring Scarless Solutions through Drug Delivery Innovations

Alavi,

Nisa

et al. 2024

Mol. Pharmaceutics

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Human skin is the largest organ and outermost surface of the human body, and due to the continuous exposure to various challenges, it is prone to develop injuries, customarily known as wounds. Although various tissue engineering strategies and bioactive wound matrices have been employed to speed up wound healing, scarring remains a significant challenge. The wound environment is harsh due to the presence of degradative enzymes and elevated pH levels, and the physiological processes involved in tissue regeneration operate on distinct time scales. Therefore, there is a need for effective drug delivery systems (DDSs) to address these issues. The objective of this review is to provide a comprehensive exposition of the mechanisms underlying the skin healing process, the factors and materials used in engineering DDSs, and the different DDSs used in wound care. Furthermore, this investigation will delve into the examination of emergent technologies and potential avenues for enhancing the efficacy of wound care devices.

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“…It is well-known that mechanical environment plays an important role in tissue regeneration. − After meshes are implanted, fibroblasts are recruited to the surface of the materials, fibroblasts differentiate into myofibroblasts, and deposit extracellular matrix (ECM) such as collagen to achieve wound repair after being stimulated by chemical or mechanical signals . Under normal circumstances, most myofibroblasts will gradually lead to apoptosis at the end of repair. , However, the abdominal wall is a tissue in constant dynamic motion and the mechanical stimulation provided to the cells is often too intense, which leads to excessive proliferation of myofibroblasts and deposition of excess ECM, resulting in scar tissue production. , These scar tissues encapsulate the mesh, making the tissue–mesh complex stiffer, which causes greater mechanical stimulation of the surrounding cells and tissues and allow further fibrosis to occur .…”

Section: Introductionmentioning

confidence: 99%

Spider-Silk-like Fiber Mat-Covered Polypropylene Warp-Knitted Hernia Mesh for Inhibition of Fibrosis under Dynamic Environment

Jiao,

Yang,

et al. 2024

Biomacromolecules

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Hernia surgery is a widely performed procedure, and the use of a polypropylene mesh is considered the standard approach. However, the mesh often leads to complications, including the development of scar tissue that wraps around the mesh and causes it to shrink. Consequently, there is a need to investigate the relationship between the mesh and scar formation as well as to develop a hernia mesh that can prevent fibrosis. In this study, three different commercial polypropylene hernia meshes were examined to explore the connection between the fabric structure and mechanical properties. In vitro dynamic culture was used to investigate the mechanism by which the mechanical properties of the mesh in a dynamic environment affect cell differentiation. Additionally, electrospinning was employed to create polycaprolactone spider-silk-like fiber mats to achieve mechanical energy dissipation in dynamic conditions. These fiber mats were then combined with the preferred hernia mesh. The results demonstrated that the composite mesh could reduce the activation of fibroblast mechanical signaling pathways and inhibit its differentiation into myofibroblasts in dynamic environments.

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Mechanomodulatory biomaterials prospects in scar prevention and treatment

Cited by 18 publications

References 94 publications

New insights into balancing wound healing and scarless skin repair

New insights into balancing wound healing and scarless skin repair

Revolutionizing Wound Healing: Exploring Scarless Solutions through Drug Delivery Innovations

Spider-Silk-like Fiber Mat-Covered Polypropylene Warp-Knitted Hernia Mesh for Inhibition of Fibrosis under Dynamic Environment

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