2023
DOI: 10.1177/20417314231185848
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New insights into balancing wound healing and scarless skin repair

Abstract: Scars caused by skin injuries after burns, wounds, abrasions and operations have serious physical and psychological effects on patients. In recent years, the research of scar free wound repair has been greatly expanded. However, understanding the complex mechanisms of wound healing, in which various cells, cytokines and mechanical force interact, is critical to developing a treatment that can achieve scarless wound healing. Therefore, this paper reviews the types of wounds, the mechanism of scar formation in t… Show more

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Cited by 15 publications
(2 citation statements)
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“…Acute or chronic wound healing caused by burns and trauma is a major medical and social problem, and the mechanisms involved in wound repair process need to be elucidated. 17 Wounds in oral mucosa are able to heal more rapidly and without scar than skin wounds though the factors in basal state of oral mucosa; 10,12 however, the potential factors promoting rapidly wound healing in basal state still need to be explored. Here, we identified the gene module and pathways enriched in basal state of oral mucosa.…”
Section: Discussionmentioning
confidence: 99%
“…Acute or chronic wound healing caused by burns and trauma is a major medical and social problem, and the mechanisms involved in wound repair process need to be elucidated. 17 Wounds in oral mucosa are able to heal more rapidly and without scar than skin wounds though the factors in basal state of oral mucosa; 10,12 however, the potential factors promoting rapidly wound healing in basal state still need to be explored. Here, we identified the gene module and pathways enriched in basal state of oral mucosa.…”
Section: Discussionmentioning
confidence: 99%
“…Several crucial cellular behaviors, including re‐epithelialization, angiogenesis, and fibroblast activation, occur during the proliferative phase 126,127 . Recent studies have demonstrated that natural sEVs may exert therapeutic effects by enhancing the proliferation and migration, 23,128 and mitigating oxidative stress‐induced senescence of HUVECs, 129 or inhibiting the apoptosis and recovering cellular function of HaCaTs 130 .…”
Section: Applications Of Engineered Sevs In Diabetic Wound Managementmentioning
confidence: 99%