Mechanochemically synthesized phase stable and biocompatible β-tricalcium phosphate from avian eggshell for the development of tissue ingrowth system

Roopavath, Uday Kiran; Sah, Mahesh Kumar; Panigrahi, Bharat B.; Rath, Subha Narayan

doi:10.1016/j.ceramint.2019.03.217

Cited by 29 publications

(20 citation statements)

References 36 publications

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“…Out of 71 relevant article titles collected from SCOPUS, PubMed, and Google Scholar, only 36 were included after screening the title, abstract, and content for in vitro degradation and cytotoxicity testing for the biocompatibility of eggshell-based hydroxyapatite. The articles came from several countries, such as India [ 11 , 14 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ], Bangladesh [ 41 , 42 ], China [ 43 ], Korea [ 25 , 44 , 45 ], Turkey [ 46 , 47 , 48 ], Thailand [ 49 , 50 ], Brazil [ 26 ], Italy [ 51 ], USA [ 52 ], Romania [ 2 ], Vietnam [ 53 , 54 ], Colombia [ 55 ], and Egypt [ 56 ]. The study selection of the articles included in the systematic review is shown in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The qualitative results are displayed in the Figure 3 , showing the appearance of the surface morphology of the materials. Of the articles included in this review, the qualitative results involved seven cytotoxicity tests, from the articles of [ 32 , 34 , 38 , 44 , 48 , 51 , 52 ].…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Table 2 , several studies have produced eggshell-based hydroxyapatite materials that were mixed with other elements. Biocompatibility and bioactivity can be affected by the presence of minor elements that are present within the environment; for example, Mg 2+ , Al 3+ , Sr 2+ , Zn 2+ , K + , and Na can facilitate rapid bone regeneration [ 52 ], and minor impurities do not have any adverse effect on cell attachment and proliferation [ 32 ]. Ions play an important role in bone biology, cell spreading, and adhesiveness.…”

Section: Discussionmentioning

confidence: 99%

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In Vitro Degradation and Cytotoxicity of Eggshell-Based Hydroxyapatite: A Systematic Review and Meta-Analysis

et al. 2021

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Objective: This review focuses on the in vitro degradation of eggshell-based hydroxyapatite for analyzing the weight loss of hydroxyapatite when applied in the human body. Cytotoxicity tests were used to observe cell growth and morphological effects. A systematic review and meta-analysis were conducted to observe the weight loss and viable cells of hydroxyapatite when used for implants. Method: Based on the Population, Intervention, Comparison, and Outcome (PICO) strategy, the articles used for literature review were published in English on SCOPUS, PubMed, and Google Scholar from 1 January 2012 to 22 May 2021. Data regarding existing experiments in the literature articles the in vitro degradation and cytotoxicity testing of eggshell-based hydroxyapatite determined the biocompatibility of the materials. A meta-analysis was conducted to calculate the mean difference between the solutions and soaking times used for degradation and the stem cells used for cytotoxicity. Results: From 231 relevant studies, 71 were chosen for full-text analysis, out of which 33 articles met the inclusion criteria for degradation and cytotoxicity analysis. A manual search of the field of study resulted in three additional articles. Thus, 36 articles were included in this systematic review. Significance: The aim of this study was to highlight the importance of the biocompatibility of eggshell-based hydroxyapatite. The weight loss and viability cells of eggshell-based hydroxyapatite showed optimum results for viable cells requirements above 70%, and there is a weight loss of eggshell-based hydroxyapatite for a material implant. The meta-analysis indicated significant differences in the weight loss of eggshell-based hydroxyapatite materials with different soaking times and solutions used. The various kinds of stem cells for incubation of cultured cells in contact with a device, either directly or through diffusions with various kinds of stem cells from animals and humans, yielded viability cells above 70%.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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In Vitro Degradation and Cytotoxicity of Eggshell-Based Hydroxyapatite: A Systematic Review and Meta-Analysis

et al. 2021

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“…The FT-IR technique was used for the structural characterization of dental materials such as: implant materials [ 82 ], biopolymers [ 83 ], ceramics [ 84 ], resin nanocomposites [ 85 ], implant coatings [ 86 , 87 , 88 ], bioceramics [ 89 ], resins [ 90 , 91 , 92 , 93 , 94 ], cements [ 95 ], bioglass [ 96 ], and self-curing materials [ 97 ].…”

Section: Infrared Spectroscopy (Ir) and Fourier Transform Infrared Spectroscopy (Ft-ir)mentioning

confidence: 99%

Selected Spectroscopic Techniques for Surface Analysis of Dental Materials: A Narrative Review

et al. 2021

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The presented work focuses on the application of spectroscopic methods, such as Infrared Spectroscopy (IR), Fourier Transform Infrared Spectroscopy (FT-IR), Raman spectroscopy, Ultraviolet and Visible Spectroscopy (UV-Vis), X-ray spectroscopy, and Mass Spectrometry (MS), which are widely employed in the investigation of the surface properties of dental materials. Examples of the research of materials used as tooth fillings, surface preparation in dental prosthetics, cavity preparation methods and fractographic studies of dental implants are also presented. The cited studies show that the above techniques can be valuable tools as they are expanding the research capabilities of materials used in dentistry.

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“…β-TCP has a comparable chemical composition to HAp; however, it is considered resorbable in vivo due to its faster release of Ca 2+ and PO 4 3− ions when exposed to physiological fluids [ 16 , 17 ]. As bone graft substitutes, mixtures of the stable HAp with Ca/P ratio of 1.67 and the soluble β-TCP with Ca/P ratio of 1.5 have demonstrated higher efficacy for degradation rate to match the new bone formation rate when compared with single-phase HAP or β-TCP [ 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Ceramic Composite: Characterization, Cell Response, and In Vivo Biocompatibility

Lin

Chou

et al. 2021

Materials

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The present study aimed to synthesize biphasic calcium phosphate ceramics (CaPs) composed of β-tricalcium phosphate (β-TCP) and hydroxyapatite (HAp) from the propagated Scleractinian coral and dicalcium phosphate anhydrous using a solid-state reaction followed by heat treatment at a temperature of 1100 °C for 1 h to 7 days. The as-prepared coral and coral-derived biphasic CaPs samples were characterized through scanning electron microscopy, X-ray diffractometry, Fourier transform infrared spectroscopy, and Raman spectroscopy. The cell response of the biphasic CaPs was evaluated by in vitro cytotoxicity assessment using mouse fibroblast (L929) cells. The bilateral femoral defect rabbit model was used to assess the early local reaction of the coral-derived biphasic CaPs bone graft on tissue. The results confirmed that the co-existence of β-TCP and HAp was formed at 1100 °C for 1 h. The ratio of HA/β-TCP increased as the heat-treatment time increased. The coral-derived biphasic CaPs comprising 61% HAp and 39% β-TCP (defined as HT-3) were not cytotoxic. Furthermore, no significant differences in local tissue reaction were observed between the HT-3 sample and autogenous bone. Therefore, the synthesized coral-derived biphasic CaPs is a candidate for bone grafting due to its good biocompatibility.

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Mechanochemically synthesized phase stable and biocompatible β-tricalcium phosphate from avian eggshell for the development of tissue ingrowth system

Cited by 29 publications

References 36 publications

In Vitro Degradation and Cytotoxicity of Eggshell-Based Hydroxyapatite: A Systematic Review and Meta-Analysis

In Vitro Degradation and Cytotoxicity of Eggshell-Based Hydroxyapatite: A Systematic Review and Meta-Analysis

Selected Spectroscopic Techniques for Surface Analysis of Dental Materials: A Narrative Review

Biomimetic Ceramic Composite: Characterization, Cell Response, and In Vivo Biocompatibility

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