Mechanochemical Strecker Reaction: Access to α‐Aminonitriles and Tetrahydroisoquinolines under Ball‐Milling Conditions

Hernández, José G.; Turberg, Mathias; Schiffers, Ingo; Bolm, Carsten

doi:10.1002/chem.201603057

Cited by 68 publications

(51 citation statements)

References 48 publications

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“…An umber of multi-component reactions have been adapted to mechanochemistry,including Biginelli, [105] Strecker, [106] Ugi and Passerini reactions, [67] validating orthogonal and cascade reaction designs in as olvent-free environment. Thep otential of mechanochemistry in that sense was ex-plored by Hernµndez et al [107] who developed ao ne-step 5component route to build Re I complexes from asimple metal carbonyl, based on orthogonal oxidative addition and ligand exchange (Figure 11 a).…”

Section: Multi-component and Multi-step Reactionsmentioning

confidence: 99%

Mechanochemistry for Synthesis

2019

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Mechanochemical solvent‐free reactions by milling, grinding or other types of mechanical action have emerged as a viable alternative to solution chemistry. Mechanochemistry offers not only a possibility to eliminate the need for bulk solvent use, and reduce the generation of waste, but it also unlocks the door to a different reaction environment in which synthetic strategies, reactions and molecules previously not accessible in solution, can be achieved. This Minireview examines the potential of mechanochemistry in chemical and materials synthesis, by providing a cross‐section of the recent developments in using ball milling for the formation of molecules and materials based on covalent and coordination bonds.

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Section: Multi-component and Multi-step Reactionsmentioning

confidence: 99%

Mechanochemistry for Synthesis

2019

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“…Before mechanochemistry was established for advanced materials syntheses, ball milling was primarily used for particle‐size reduction and alloying . Recent studies in the fields of pharmaceutical chemistry, organic chemistry, and inorganic chemistry, especially in the field of metal–organic frameworks (MOFs), have demonstrated the tremendous potential of mechanochemistry. However, the mechanochemical synthesis of porous carbon has remained largely unexplored.…”

Section: Introductionmentioning

confidence: 99%

Solvent‐Free Mechanochemical Synthesis of Nitrogen‐Doped Nanoporous Carbon for Electrochemical Energy Storage

et al. 2017

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Nitrogen-doped nanoporous carbons were synthesized by a solvent-free mechanochemically induced one-pot synthesis. This facile approach involves the mechanochemical treatment and carbonization of three solid materials: potassium carbonate, urea, and lignin, which is a waste product from pulp industry. The resulting nitrogen-doped porous carbons offer a very high specific surface area up to 3000 m g and large pore volume up to 2 cm g . The mechanochemical reaction and the impact of activation and functionalization are investigated by nitrogen and water physisorption and high-resolution X-ray photoelectron spectroscopy (XPS). Our N-doped carbons are highly suitable for electrochemical energy storage as supercapacitor electrodes, showing high specific capacitances in aqueous 1 m Li SO electrolyte (177 F g ), organic 1 m tetraethylammonium tetrafluoroborate in acetonitrile (147 F g ), and an ionic liquid (1-ethyl-3-methylimidazolium tetrafluoroborate; 192 F g ). This new mechanochemical pathway synergistically combines attractive energy-storage ratings with a scalable, time-efficient, cost-effective, and environmentally favorable synthesis.

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“…Multicomponent reactions (MCRs) have gained importance because of their efficiency and effectiveness as a method for one-pot synthesis of a wide range of heterocycles [1][2][3][4][5][6]. The optimal MCR is sufficiently flexible.…”

Section: Introductionmentioning

confidence: 99%

Green High-Yielding One-Pot Approach to Biginelli Reaction under Catalyst-Free and Solvent-Free Ball Milling Conditions

2016

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A simple, green, and efficient approach was used to synthesize 3,4-dihydropyrimidines derivatives. We showed that the application of the planetary ball milling method with a ball-to-reagent weight ratio of 8 for the Biginelli reaction provides 3,4-dihydropyrimidines derivatives with excellent yields (>98%) in a short reaction time from the one-pot, three-component condensation of aldehydes, ethyl acetoacetate, and urea (or thiourea).

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Mechanochemical Strecker Reaction: Access to α‐Aminonitriles and Tetrahydroisoquinolines under Ball‐Milling Conditions

Cited by 68 publications

References 48 publications

Mechanochemistry for Synthesis

Mechanochemistry for Synthesis

Solvent‐Free Mechanochemical Synthesis of Nitrogen‐Doped Nanoporous Carbon for Electrochemical Energy Storage

Green High-Yielding One-Pot Approach to Biginelli Reaction under Catalyst-Free and Solvent-Free Ball Milling Conditions

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