Mechano-responsive microRNA-functionalized PDLSC exosomes as a novel therapeutic for inflammatory bone loss in periodontitis

Wang, Rui; Liao, Li; Huang, Xiao‐Jun; Ma, Shixing; Wang, Shuang; Qiao, Hui; Zhou, Hong; Zou, Jing; Su, Xiaoxia

doi:10.1016/j.cej.2023.141488

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Specifically, biophysical stimulation has been shown to enhance the osteogenic potential of PDLSC-Exos, thereby facilitating alveolar bone regeneration in periodontitis and offering a novel therapeutic avenue for the management of periodontal bone loss. Furthermore, it has been demonstrated that the miR200 family of bone marrow mesenchymal stem cell miRNAs serves as the primary mechano-responsive miRNA that initiates osteogenic differentiation ( Wang et al, 2023 ). Based on these studies, we speculate that the osteogenic ability of exosomes can be enhanced through appropriate mechanical stimulation and other pretreatment methods, providing new directions for future research.…”

Section: Exosomes In Periodontal Tissue Repairmentioning

confidence: 99%

Exosomes and exosome composite scaffolds in periodontal tissue engineering

Wang,

Zhou,

Zhang

et al. 2024

Front. Bioeng. Biotechnol.

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Promoting complete periodontal regeneration of damaged periodontal tissues, including dental cementum, periodontal ligament, and alveolar bone, is one of the challenges in the treatment of periodontitis. Therefore, it is urgent to explore new treatment strategies for periodontitis. Exosomes generated from stem cells are now a promising alternative to stem cell therapy, with therapeutic results comparable to those of their blast cells. It has great potential in regulating immune function, inflammation, microbiota, and tissue regeneration and has shown good effects in periodontal tissue regeneration. In addition, periodontal tissue engineering combines exosomes with biomaterial scaffolds to maximize the therapeutic advantages of exosomes. Therefore, this article reviews the progress, challenges, and prospects of exosome and exosome-loaded composite scaffolds in periodontal regeneration.

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Section: Exosomes In Periodontal Tissue Repairmentioning

confidence: 99%

Exosomes and exosome composite scaffolds in periodontal tissue engineering

Wang,

Zhou,

Zhang

et al. 2024

Front. Bioeng. Biotechnol.

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“…Based on the phenomenon, Wang et al [ 171 ] found exosomes secreted from the PDLSCs stimulated with tension significantly enhanced the osteogenesis of BMSCs compared with those from untreated PDLSCs. They further clarified that mechano-responsive micro-RNA miR-200b/c carried by these exosomes targets Smurf1 to activate the BMP-Smad signaling pathway, thus promoting osteogenic differentiation of mandibular BMSCs [ 172 ]. Their works suggest a novel therapeutic for bone loss in periodontitis.…”

Section: Current Modifications Of Bone Repair Materialsmentioning

confidence: 99%

Advances in biomaterials for oral-maxillofacial bone regeneration: spotlight on periodontal and alveolar bone strategies

Li,

Wang,

Feng

et al. 2024

Regenerative Biomaterials

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The intricate nature of oral-maxillofacial structure and function, coupled with the dynamic oral bacterial environment, presents formidable obstacles in addressing the repair and regeneration of oral-maxillofacial bone defects. Numerous characteristics should be noticed in oral-maxillofacial bone repair, such as irregular morphology of bone defects, homeostasis between hosts and microorganisms in the oral cavity, and complex periodontal structures that facilitate epithelial ingrowth. Therefore, oral-maxillofacial bone repair necessitates restoration materials that adhere to stringent and specific demands. This review starts with exploring these particular requirements by introducing the particular characteristics of oral-maxillofacial bones, and then summarizes the classifications of current bone repair materials in respect of composition and structure. Additionally, we discuss the modifications in current bone repair materials including improving mechanical properties, optimizing surface topography and pore structure, and adding bioactive components such as elements, compounds, cells, and their derivatives. Ultimately, we organize a range of potential optimization strategies and future perspectives for enhancing oral-maxillofacial bone repair materials, including physical environment manipulation, oral microbial homeostasis modulation, osteo-immune regulation, smart stimuli-responsive strategies and multifaceted approach for poly-pathic treatment, in the hope of providing some insights for researchers in this field. In summary, this review analyzes the complex demands of oral-maxillofacial bone repair, especially for periodontal and alveolar bone, concludes multifaceted strategies for corresponding biomaterials, and aims to inspire future research in the pursuit of more effective treatment outcomes.

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Mechano-responsive microRNA-functionalized PDLSC exosomes as a novel therapeutic for inflammatory bone loss in periodontitis

Cited by 2 publications

References 27 publications

Exosomes and exosome composite scaffolds in periodontal tissue engineering

Exosomes and exosome composite scaffolds in periodontal tissue engineering

Advances in biomaterials for oral-maxillofacial bone regeneration: spotlight on periodontal and alveolar bone strategies

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