Mechanistic evaluation of phytochemicals in breast cancer remedy: current understanding and future perspectives

Younas, Muhammad; Hano, Christophe; Giglioli-Guivarc’h, Nathalie; Abbasi, Bilal Haider

doi:10.1039/c8ra04879g

Cited by 62 publications

(68 citation statements)

References 377 publications

(314 reference statements)

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“…There are several classes of phytochemicals, which are used as antivirals ( Fig. 1) (Rex et al 2018;Younas et al 2018). These include phenolics, carotenoids, terpenoids, and alkaloids.…”

Section: Plant-based Antiviral Moleculesmentioning

confidence: 99%

Phytochemicals as Antiviral Agents: Recent Updates

Ghildiyal

Prakash

Chaudhary

et al. 2020

Plant-Derived Bioactives

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“…There are several classes of phytochemicals, which are used as antivirals ( Fig. 1) (Rex et al 2018;Younas et al 2018). These include phenolics, carotenoids, terpenoids, and alkaloids.…”

Section: Plant-based Antiviral Moleculesmentioning

confidence: 99%

Phytochemicals as Antiviral Agents: Recent Updates

Ghildiyal

Prakash

Chaudhary

et al. 2020

Plant-Derived Bioactives

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“…Downward arrows (↓) represent downregulation while upward arrows (↑) represent upregulation. This figure was modified from [ 55 ].…”

Section: Figurementioning

confidence: 99%

Perspectives on the Role of Isoliquiritigenin in Cancer

Wang

Hsia

2021

Cancers

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Isoliquiritigenin (2′,4′,4-trihydroxychalcone, ISL), one of the most important bioactive compounds with a chalcone structure, is derived from licorice root. Licorice is commonly known as Glycyrrhiza, including Glycyrrhiza uralensis, Glycyrrhiza radix, and Glycyrrhiza glabra, which are generally available in common foods and Chinese herbal medicines based on a wide variety of biological functions and pharmacological effects, and its derivative (ISL) is utilized as a food additive and adjunct disease treatment. In this review, we summarized the progress over the last 10 years in the targeted pathways and molecular mechanisms of ISL that are involved in the regulation of the onset and progression of different types of cancers.

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“…The American Cancer Society also made a survey in this regard and confirmed that more female mortalities are due to cancer. [ 1 ] The main etiology of breast cancer is the 17β‐estradiol, a female sex hormone that has an important effect on the entire women life span. The increase of estrogen level in the body is one of the main causes of development of breast tumors.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, anticancer evaluation, and docking studies of some novel azo chromene derivatives

Bhuvaneswari

Sivaguru

Lalitha

2020

J Chinese Chemical Soc

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We have described a simple, convenient, and high-yielding one-pot synthesis of novel azo chromene derivatives via a three-component reaction of various azo aldehydes with dimedone and malononitrile using 10 mol% of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as catalyst and ethanol as solvent at reflux condition. All the synthesized compounds have been characterized using Fourier-transform infrared spectroscopy (FT-IR), 1 H NMR, 13 C NMR, and HR-MS spectra and molecular docking was performed to explore new inhibitors of human placental aromatase cytochrome P450 and cyclooxygenase-2 enzymes. Of all the compounds docked, compound (E)-2-amino-4-(4,4-dimethyl-2,6-dioxocyclohexyl)-6-((3-methoxyphenyl)diazenyl-4H-chromene-3-carbonitrile (4o) showed good binding affinity with the active site of human placental aromatase cytochrome P450 enzyme (PDB: 3EQM) with inhibition constant (Ki) 1.66 nM and compound 4o also showed good binding affinity with the active site of cyclooxygenase-2 enzyme (PDB: 6COX) with inhibition constant (Ki) 367.17 pM. In vitro anti-cancer activity studies against MCF-7 cells were also performed for compounds 4o, anastrozole and celecoxib. Compound 4o showed an effective cytotoxicity at 19.8 μg/ml compared to anastrozole and celecoxib (24.7 and 26.2 μg/ml).

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Mechanistic evaluation of phytochemicals in breast cancer remedy: current understanding and future perspectives

Abstract: Breast cancer is one of the most commonly diagnosed cancers around the globe and accounts for a large proportion of fatalities in women.

Cited by 62 publications

References 377 publications

Phytochemicals as Antiviral Agents: Recent Updates

Phytochemicals as Antiviral Agents: Recent Updates

Perspectives on the Role of Isoliquiritigenin in Cancer

Synthesis, anticancer evaluation, and docking studies of some novel azo chromene derivatives

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