An efficient one‐pot multicomponent double Michael addition strategy was developed for the synthesis of novel curcumin derivatives using 1,4‐diazabicyclo [2.2.2] octane (DABCO) as the catalyst. Selected compounds (E)‐4,4′′,5′‐trihydroxy‐6′‐(3‐(4‐hydroxy‐3‐methoxyphenyl)acryloyl)‐3,3′′‐dimethoxy‐3′,4′‐dihydro‐[1, 1′:3′, 1′′‐terphenyl]‐2′,2′(1′H)‐dicarbonitrile (4 k) and (E)‐ethyl 2′‐cyano‐4′′,5′‐dihydroxy‐6′‐(3‐(4‐hydroxy‐3‐methoxyphenyl)acryloyl)‐3′′‐methoxy‐4‐methyl‐1′,2′,3′,4′‐tetrahydro‐[1, 1′:3′, 1′′‐terphenyl]‐2′‐carboxylate (6 j) were evaluated for their in‐vitro anticancer activities against human breast cancer cells (MCF‐7) and human normal breast cells (HBL 100) and found to show effective cytotoxicity on MCF‐7 cells and less cytotoxicity on HBL 100 cells than simple curcumin. In addition, molecular docking studies helped to rationalize anti‐apoptotic Bcl‐2 binding of all the synthesized compounds and revealed that the docking of compounds 4 k and 6 j with Bcl‐2 was more potent compared to curcumin.
Large cities with fleet of vehicles require a system to determine location of movement of passenger vehicles at a given time. Vehicle tracking systems can be used in theft prevention, retrieval of lost vehicles, providing trafricoriented services on lanes. The Vehicle tracking systems VETRAC enables vehicle drivers or any third party to track the location of any moving vehicle. Most modern vehicle tracking systems use GPS[71 modules which is costly in usage and implementation. Many systems also combine a communications component such as cellular or satellite transmitters to communicate the vehicle's location to a remote user. VETRAC uses WiFi IEEE 802.11 b/g for easy and accurate location of the vehicle, which provides effective and simple communication. Vehicle information can be viewed on electronic maps using the Internet or specialized software. We have designed and developed an Intelligent Vehicle Navigation System, which identify an optimally minimal path for navigation with minimal traffic intensity using WiFi. The system can also be used as a city guide to locate and identify landmarks in a new city.
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