Mechanistic Evaluation of Echocardiographic Dyssynchrony Indices

Lumens, Joost; Leenders, Geert E.; Cramer, Maarten J.; Boeck, Bart W.L. De; Doevendans, Pieter A.; Prinzen, Frits W.; Delhaas, Tammo

doi:10.1161/circimaging.112.973446

Cited by 68 publications

(30 citation statements)

References 37 publications

(62 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The septal-to-posterior wall motion delay is bimodal owing to the septal flash (50). Combining the strain dyssynchrony index derived from radial, circumferential and longitudinal strains holds better predictive value for CRT outcome than using a single parameter alone (51).…”

Section: Evidence For 2dste In Predicting Response To Crtmentioning

confidence: 99%

Clinical utility of speckle-tracking echocardiography in cardiac resynchronisation therapy

et al. 2016

View full text Add to dashboard Cite

Cardiac resynchronisation therapy (CRT) can profoundly improve outcome in selected patients with heart failure; however, response is difficult to predict and can be absent in up to one in three patients. There has been a substantial amount of interest in the echocardiographic assessment of left ventricular dyssynchrony, with the ultimate aim of reliably identifying patients who will respond to CRT. The measurement of myocardial deformation (strain) has conventionally been assessed using tissue Doppler imaging (TDI), which is limited by its angle dependence and ability to measure in a single plane. Two-dimensional speckle-tracking echocardiography is a technique that provides measurements of strain in three planes, by tracking patterns of ultrasound interference (‘speckles’) in the myocardial wall throughout the cardiac cycle. Since its initial use over 15 years ago, it has emerged as a tool that provides more robust, reproducible and sensitive markers of dyssynchrony than TDI. This article reviews the use of two-dimensional and three-dimensional speckle-tracking echocardiography in the assessment of dyssynchrony, including the identification of echocardiographic parameters that may hold predictive potential for the response to CRT. It also reviews the application of these techniques in guiding optimal LV lead placement pre-implant, with promising results in clinical improvement post-CRT.

show abstract

Section: Evidence For 2dste In Predicting Response To Crtmentioning

confidence: 99%

Clinical utility of speckle-tracking echocardiography in cardiac resynchronisation therapy

et al. 2016

View full text Add to dashboard Cite

show abstract

“…43 In another CircAdapt study, during gradual pre-excitation of the septum compared with the LV free wall, the time to peak shortening in the septum shortened in two major steps, providing a poor quantitative reflection of true dyssynchrony. 36 Together with the data published by Kerckhoffs et al 42 these observations plead for the use of parameters of dyssynchrony that describe the shortening/deformation pattern rather than the time to peak shortening.…”

Section: Left: Activation Times Calculated By Solving the Eikonal-difmentioning

confidence: 75%

“…35,36 In early-activated regions, a rapid early systolic fibre shortening was found, followed by strongly reduced late systolic shortening. Later-activated regions were characterised by early systolic lengthening followed by pronounced systolic shortening.…”

Section: Some Achievements Of Mechanical Modelsmentioning

confidence: 99%

Computer Modelling for Better Diagnosis and Therapy of Patients by Cardiac Resynchronisation Therapy

Pluijmert

Lumens²,

Potse

et al. 2015

Arrhythmia &Amp; Electrophysiology Review

Self Cite

View full text Add to dashboard Cite

Mathematical or computer models have become increasingly popular in biomedical science. Although they are a simplification of reality, computer models are able to link a multitude of processes to each other. In the fields of cardiac physiology and cardiology, models can be used to describe the combined activity of all ion channels (electrical models) or contraction-related processes (mechanical models) in potentially millions of cardiac cells. Electromechanical models go one step further by coupling electrical and mechanical processes and incorporating mechano-electrical feedback. The field of cardiac computer modelling is making rapid progress due to advances in research and the ever-increasing calculation power of computers. Computer models have helped to provide better understanding of disease mechanisms and treatment. The ultimate goal will be to create patient-specific models using diagnostic measurements from the individual patient. This paper gives a brief overview of computer models in the field of cardiology and mentions some scientific achievements and clinical applications, especially in relation to cardiac resynchronisation therapy (CRT).

show abstract

“…Similar clustering of time-to-peak data was observed in CRT patients. 38 All these issues may explain why the use of mechanical dyssynchrony in CRT is still controversial (see below).…”

Section: Mechanical Dyssynchrony Versus Mechanical Discoordinationmentioning

confidence: 99%

Cardiac Resynchronization Therapy

Prinzen¹,

2013

Self Cite

View full text Add to dashboard Cite

Mechanistic Evaluation of Echocardiographic Dyssynchrony Indices

Cited by 68 publications

References 37 publications

Clinical utility of speckle-tracking echocardiography in cardiac resynchronisation therapy

Clinical utility of speckle-tracking echocardiography in cardiac resynchronisation therapy

Computer Modelling for Better Diagnosis and Therapy of Patients by Cardiac Resynchronisation Therapy

Cardiac Resynchronization Therapy

Contact Info

Product

Resources

About