Computer Modelling for Better Diagnosis and Therapy of Patients by Cardiac Resynchronisation Therapy

Pluijmert, MH Marieke; Lumens, Joost; Potse, Mark; Delhaas, Tammo; Auricchio, Angelo; Prinzen, Frits W.

doi:10.15420/aer.2015.4.1.62

Cited by 14 publications

(11 citation statements)

References 54 publications

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“…To improve signal to noise ratio (SNR), we placed the electrodes directly on the skull of the animals and secured them with medical grade epoxy. For ECG recordings, we used radiolucent pin electrodes [61] (SA Instruments, Inc., Stony Brook, NY) and placed them in Einthoven's Triangle formation [62][63][64]. To monitor esophageal pH, we placed a pH probe, containing 1-2 electrodes, at the bottom of the esophagus according to a previous study [20].…”

Section: Electrodes and Transducersmentioning

confidence: 99%

Utilizing Multimodal Imaging to Visualize Potential Mechanism for Sudden Death in Epilepsy

Mandal¹,

Budde²,

Lawlor³

et al. 2021

Preprint

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Sudden death in epilepsy, or SUDEP, is a fatal condition that accounts for more than 4000 deaths each year. Limited clinical and preclinical data on sudden death suggests critical contributions from autonomic, cardiac, and respiratory pathways. Recent animal (rat) studies on kainic acid induced seizure models explored a potential mechanism for such sudden and severe cardiorespiratory dysregulation being linked to acid reflux induced laryngospasm. Here, we expand on those previous investigations and utilize a multimodal approach to provide visual evidence of acid reflux-initiated laryngospasm and subsequent fatal cardiorespiratory distress in seizing rats.We used systemic kainic acid to acutely induce seizure activity in Long Evans rats, under urethane anesthesia. We recorded electroencephalography (EEG), electrocardiography (ECG), chest plethysmography and esophageal pH signals during simultaneous fast MRI scans of the rat stomach and esophagus. MRI images, in conjunction with electrophysiology data were used to identify seizure progression, stomach acid movement up the esophagus, cardiorespiratory changes, and sudden death.In all cases of sudden death, esophageal pH recordings alongside MRI images visualized stomach acid movement up the esophagus. Severe cardiac (ST segment elevation), respiratory (intermittent apnea) and brain activity (EEG narrowing due to hypoxia) changes were observed only after acid reached the larynx, which strongly suggests onset of laryngospasm following acid reflux. Additionally, absence of stomach acid in the esophagus of animals that survived acute seizure, provided evidence of a causal relationship between acid reflux and sudden death. The complimentary information coming from electrophysiology and fast MRI scans provided insight into the mechanism of esophageal reflux, laryngospasm, obstructive apnea, and subsequent sudden death in seizing animals. The results carry clinical significance as they outline a potential mechanism that may be relevant to SUDEP in humans.

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Section: Electrodes and Transducersmentioning

confidence: 99%

Utilizing Multimodal Imaging to Visualize Potential Mechanism for Sudden Death in Epilepsy

Mandal¹,

Budde²,

Lawlor³

et al. 2021

Preprint

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“…The rat's fur was first trimmed using a conventional trimmer, then completely removed using hair removal cream. Ag/AgCl, radiolucent ECG electrodes [43] (NeoTech Products, Inc., CA, USA) were placed in Einthoven's Triangle formation [16], [44] for recording.…”

Section: ) Phantom and Animal Preparation-mentioning

confidence: 99%

Adaptive and Wireless Recordings of Electrophysiological Signals During Concurrent Magnetic Resonance Imaging

Mandal

Babaria²,

Cao

et al. 2019

IEEE Trans. Biomed. Eng.

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Strong electromagnetic fields that occur during functional magnetic resonance imaging (fMRI) presents a challenging environment for concurrent electrophysiological recordings. Here, we present a miniaturized, wireless platform-"MR-Link" (Multimodal Recording Link) that provides a hardware solution for simultaneous electrophysiological and fMRI signal acquisition. The device detects the changes in the electromagnetic field during fMRI to synchronize amplification and sampling of electrophysiological signals with minimal artifacts. It wirelessly transmits the recorded data at a frequency detectable by the MR-receiver coil. The transmitted data is readily separable from MRI in the frequency domain. To demonstrate its efficacy, we used this device to record electrocardiograms and somatosensory evoked potential during concurrent fMRI scans. The device minimized the fMRI-induced artifacts in electrophysiological data and wirelessly transmitted the data back to the receiver coil without compromising fMRI signal quality. The device is compact (22 mm dia., 2gms) and can be placed within the MR-bore to precisely synchronize with fMRI. Therefore, MR-Link offers an inexpensive system by eliminating the need for amplifiers with a high dynamic range, high-speed sampling, additional storage or synchronization hardware for electrophysiological signal acquisition. It is expected to enable a broader range of applications of simultaneous fMRI and electrophysiology in animals and humans.

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“…More detailed electrophysiological questions, such as interaction between ion channels or activation propagation differences between endocardial and epicardial pacing, could be addressed by models describing electrical propagations in more detail 85,86,89 . Since CircAdapt is based on a one-fiber sarcomere model, finite element modeling on the mechanics would be required to address research questions related to the role of myofiber orientation of transmural differences 85,86,89,90 .…”

Section: Limitations Of the Circadapt Modelmentioning

confidence: 99%

Pacing the heart

Huntjens¹

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Computer Modelling for Better Diagnosis and Therapy of Patients by Cardiac Resynchronisation Therapy

Cited by 14 publications

References 54 publications

Utilizing Multimodal Imaging to Visualize Potential Mechanism for Sudden Death in Epilepsy

Utilizing Multimodal Imaging to Visualize Potential Mechanism for Sudden Death in Epilepsy

Adaptive and Wireless Recordings of Electrophysiological Signals During Concurrent Magnetic Resonance Imaging

Pacing the heart

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