Mechanistic basis and preliminary practice of butyric acid and butyrate sodium to mitigate gut inflammatory diseases: a comprehensive review

Zhang, Mingbao; Wang, Yanan; Zhao, Xianqi; Liu, Chang; Wang, Baozhen; Zha, Jun

doi:10.1016/j.nutres.2021.08.007

Cited by 26 publications

(16 citation statements)

References 183 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies had indicated that butyric acid participated in adipose differentiation and could hydrolyze triglyceride-rich lipoproteins, thus, the increase of butyric acid is beneficial to the lipid homeostasis across biological system (Cardona et al, 2018; He & Moreau, 2019 ). Studies had shown a link between reduced butyric acid content and gastrointestinal diseases ( Zhang, Wang, Zhao, Liu, Wang, & Zhou, 2021 ). In this study, increased abundances of butyrate-producing bacteria, such as Bacteroides , Lactobacillus , unclassified f Lachnospiraceae , and Blautia, demonstrate that cinnamaldehyde microcapsules may influence the makeup of the gut microbiota to affect SCFA synthesis.…”

Section: Resultsmentioning

confidence: 99%

Cinnamaldehyde microcapsules enhance bioavailability and regulate intestinal flora in mice

Xiao

Zhang

et al. 2022

Food Chemistry: X

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Cinnamaldehyde microcapsules enhance bioavailability and regulate intestinal flora in mice

Xiao

Zhang

et al. 2022

Food Chemistry: X

View full text Add to dashboard Cite

“…34 In humans, butyrate is consistently not detected in peripheral blood, suggesting it is absorbed and completely metabolised either in the intestine mucosa or in the liver. 20 Following cell uptake, butyrate enters the mitochondrial fatty acid oxidation pathway and its product acetyl-CoA enters the TCA cycle, being converted to citrate and then oxaloacetate, ending up as triose-phosphate to be used for glucose synthesis 37,38 (Figure 1). Butyrate can also be metabolised to other fatty acids, cholesterol and ketone bodies.…”

Section: Butyric Acid-metabolism and Biological Functionsmentioning

confidence: 99%

“…Following cell uptake, butyrate enters the mitochondrial fatty acid oxidation pathway and its product acetyl‐CoA enters the TCA cycle, being converted to citrate and then oxaloacetate, ending up as triose‐phosphate to be used for glucose synthesis 37,38 (Figure 1). Butyrate can also be metabolised to other fatty acids, cholesterol and ketone bodies 38 …”

Section: Butyric Acid and Derivate Forms—characterisationmentioning

confidence: 99%

Tributyrin supplementation in fish and crustacean nutrition: A review

Palma

Magnoni

Morais³

et al. 2022

Reviews in Aquaculture

View full text Add to dashboard Cite

Short-chain fatty acids, including butyrate and its derived forms, have been used as dietary supplements to reverse or ameliorate the potential negative effects of plantderived ingredients in aquaculture diets, and have a multitude of well-demonstrated physiological and health enhancing effects in mammals and livestock. Tributyrin, a butyric acid derivate, has been assessed as a supplement in the diets of farmed animals, with promising results in several species. In fish and crustaceans, the dietary inclusion of tributyrin is more recent and has been less studied but results suggest that it may be highly advantageous for aquatic animals. This is particularly important for carnivorous species, whose diets need to be optimised towards the reduction of the fishmeal content to enhance the environmental and economical sustainability of the sector. The present work characterises tributyrin and presents the main results of its use as a dietary source of butyric acid in feeds for aquatic species. The main focus is given to aquaculture species and how tributyrin, as a feed supplement, can contribute to optimising plant-based aquafeeds.

show abstract

“…Under normal circumstances, the response process is temporary. However, if the infection and the elimination of damage factors do not disappear or the damage factors exist for a long time, a pathological chronic inflammatory process precede (Zhang et al., 2021), such as that involved in the occurrence of many diseases (insulin resistance and T2DM) (J. Guo & Fu, 2020; Serrano‐Lopez et al., 2021). It is hypothesized that the decrease in total lymphocytes, CD4 + , and CD4 + /CD8 + T cells are an important feature of immunodeficiency.…”

Section: Introductionmentioning

confidence: 99%

Myricetin ameliorated prediabetes via immunomodulation and gut microbiota interaction

Gao

Gong

et al. 2022

Food Frontiers

View full text Add to dashboard Cite

The global prevalence of prediabetes is on the rise, and it is of value to manage prediabetes and predisposal to diabetes at an early stage. Myricetin is a natural polyhydroxyflavonoid, found in planta with several health benefits. This study aimed to evaluate the effects of myricetin on prediabetes. In vitro assay indicated that the cell viability, endocytosis and phagocytosis of macrophages were inhibited in RAW 264.7 cells under high glucose (HG) levels, concurrent with an increase in reactive oxygen species level. Administration of myricetin at a dose of 10 μM, restored the immunosuppressive effects mediated by HG. Moreover, the viability of Jurkat cells was also inhibited concurrent with inhibition of interleukin-2 (IL-2) and interferon-gamma (IFNγ) expression levels versus increase PD-1 after treated with myricetin at the dose of 10 μM. In a prediabetic mouse model fed with high fat diet, increase in body weight, fat mass, fasting blood glucose, Triglyceride (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were observed. Flow cytometry analysis revealed a significant decrease in CD8 + T cells in the spleen and blood, whereas the expression of PD-1 on CD3 + , CD4 + , and CD8 + T cells in the spleen and lymph was significantly elevated. Administration of myricetin showed a potential hypoglycemic and lipid-lowering effect in both prevention and treatment, in addition to restoration of innate and adaptive immune immunity in mice and confirmed by the in vitro immunomodulation effect. In addition, 16S rRNA showed that myricetin ameliorated prediabetes may be This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

show abstract

Mechanistic basis and preliminary practice of butyric acid and butyrate sodium to mitigate gut inflammatory diseases: a comprehensive review

Cited by 26 publications

References 183 publications

Cinnamaldehyde microcapsules enhance bioavailability and regulate intestinal flora in mice

Cinnamaldehyde microcapsules enhance bioavailability and regulate intestinal flora in mice

Tributyrin supplementation in fish and crustacean nutrition: A review

Myricetin ameliorated prediabetes via immunomodulation and gut microbiota interaction

Contact Info

Product

Resources

About