Cinnamaldehyde microcapsules enhance bioavailability and regulate intestinal flora in mice

Xiao, Ying; Zhang, Fangfang; Xu, H.; Yang, Changming; Song, Xiaoqiu; Zhou, Yiming; Zhou, Xiaoli; Liu, Xiaodan; Miao, Junli

doi:10.1016/j.fochx.2022.100441

Cited by 9 publications

(11 citation statements)

References 39 publications

(29 reference statements)

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“…Genome sequencing of Ligilactobacillus agilis screened from pig manure has been reported to contain sequences of garlic Q, salivaricin A, and Blp family class II bacteriocin, which are active against Listeria monocytogenes and Micrococcus luteus, respectively, and against other Gram-positive bacteria. Faecaliboculum has been described to function as a butyric acid producer . Butyric acid is often believed to directly supply energy to intestinal epithelial cells, activate intestinal immunity, and lower levels of inflammation .…”

Section: Discussionmentioning

confidence: 99%

“…Faecaliboculum has been described to function as a butyric acid producer. 40 Butyric acid is often believed to directly supply energy to intestinal epithelial cells, activate intestinal immunity, and lower levels of inflammation. 41 Hence, Faecaliboculum may have a function in protecting the intestinal barrier.…”

Section: Dietary Ales Caused Hepatic Lipid Accumulation In Mice Which...mentioning

confidence: 99%

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Digestibility of Malondialdehyde-Induced Dietary Advanced Lipoxidation End Products and Their Effects on Hepatic Lipid Accumulation in Mice

Wang

Zhang

Nie

et al. 2023

J. Agric. Food Chem.

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Advanced lipoxidation end products (ALEs) are formed by modifying proteins with lipid oxidation products. The health effects of ALEs formed in vivo have been extensively studied. However, the digestibility, safety, and health risk of ALEs in heat-processed foods remain unclear. This investigation was performed to determine the structure, digestibility, and effect on the mice liver of dietary ALEs. The results showed that malondialdehyde (MDA) was able to alter the structure of myofibrillar proteins (MPs) to form linear, loop, and cross-linked types of Schiff bases and dihydropyridine derivatives under simulated heat processing, leading to the intra-and intermolecular aggregation of MPs and, thus, reducing the digestibility of MPs. In addition, dietary ALE intake resulted in abnormal liver function and lipid accumulation in mice. The core reason for these adverse effects was the destructive effect of ALEs on the intestinal barrier. Because the damage to the intestinal barrier leads to an increase in lipopolysaccharide levels in the liver, it induces liver damage by modulating hepatic lipid metabolism.

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Section: Discussionmentioning

confidence: 99%

Section: Dietary Ales Caused Hepatic Lipid Accumulation In Mice Which...mentioning

confidence: 99%

Digestibility of Malondialdehyde-Induced Dietary Advanced Lipoxidation End Products and Their Effects on Hepatic Lipid Accumulation in Mice

Wang

Zhang

Nie

et al. 2023

J. Agric. Food Chem.

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“…Faecalibacterium , Megamonas , gut_ metagenome _g_ Desulfovibrio , Ruminococcaceae , and unclassified_f_ Lachnospiraceae increased in richness. All these improved bacterial species demonstrate improved digestion and absorption [ 34 , 35 ], leading to enhanced growth performance and immunity [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Ligilactobacillus Salivarius improve body growth and anti-oxidation capacity of broiler chickens via regulation of the microbiota-gut-brain axis

Yang,

Wang,

Liu

et al. 2023

BMC Microbiol

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Certain strains of probiotic bacteria can secret functional substances namely digestive enzymes and functional peptides to regulate physiological conditions such as digestion and anti-oxidation, which are often incorporated in industrial broiler chick production. However, few studies have detailed the action mechanisms and effects of these bacteria on regulating growth and anti-oxidation levels in broiler chickens. Ligilactobacillus salivarius is a strain of probiotic bacteria used as dietary supplement. In the present study, Ligilactobacillus salivarius was evaluated for its secreted digestive enzymes in vitro. To detailed evaluate the action mechanisms and effects of gastrointestinal tract (GIT) microbiota on alleviating anti-oxidation levels of broiler chickens through the gut-brain axis. Ligilactobacillus salivarius was cultured and supplemented in the food of broilers to evaluate the probiotic effect on growth and anti-oxidation by modulation of gut microbial composition and its functional metabolites using metagenomic and metabolomic assays. Biochemical results showed that Ligilactobacillus salivarius secreted digestive enzymes: protease, lipase, and amylase. Broiler chickens with Ligilactobacillus salivarius supplemented for 42 days, showed increased body weights, a reduced oxidative status, decreased malondialdehyde levels, and improved activities rates of total superoxide dismutase, glutathione peroxidase IIand IV improved. The microbial composition of caecum was more abundant than those broiler without probiotics supplementation, owing 400 of total number (489) of bacterial operational taxonomic units (OTU). The genera of Lactobacillus, Megamonas, Ruminoccoccaceae, Ruminococcus, Alistipes and Helicobacter shared the dominant proportion of Candidatus _Arthromitus compared with the control chickens. These functional bacteria genera assisted in the transportation and digestion of amino acids, carbohydrates, and ions, synthesis of cellular membranes, and anti-oxidation. Uncultured_organism_g_ Anaerosporobacter, Lactobacillus salivarius, uncultured_bacterium_g_ Ruminococcaceae_UCG-014, uncultured_bacterium_g_ Peptococcus were strongly and positively correlated with body growth performance and anti-oxidation. A metabonomic assay suggested that the secreted of gamma-aminobutyric acid and monobactam was metabolized according to the Kyoto Encyclopedia of Genes and Genomes analysis. In conclusion, Ligilactobacillus salivarius optimized microbial composition of the caecum and secreted functional peptides through gut-brain axis to improve the body growth and antioxidation of broiler chicken.

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“…In order to improve the stability and bioavailability of flavone fructifolia, microcapsules of flavone fructifolia were prepared by spray drying using carrageenan + modified starch, gumarabic (GA)+ modified starch, maltodextrinMD + modified starch + gelatin as wall materials [1] 2.1 Materials and Reagents fructifolia, Rutin standard (>98%), pepsin (enzyme activity 3000U/ pancreatic enzyme (enzyme activity 300000U/g) Beijing Solaibao Technology Co., LTD.; Carrageenan, acacia gum, maltodextrin, modified starch, gelatin, all food grade, Shandong Wenxing Biotechnology Co., LTD.; Sodium hydroxide, Sodium nitrite, anhydrous ethanol, Sodium dihydrogen phosphate, aluminum nitrate, disodium phosphate Shanghai Runjie Chemical Reagent Co., LTD., potassium bromide Tianjin Zhiyuan Chemical Reagent Co., LTD. : (…”

Section: Preparation Of Chu Shi Zi Microcapsulesmentioning

confidence: 99%

“…Using no standard material as blank, the absorbance value was measured at 510nm, and the absorbance (A) versus rutin concentration (C) was used to draw A standard curve, and the regression equation A=0.0035C+0.0022 (R2 =0.9994) was obtained. The absorbance value of the sample was determined by the same method, the flavonoid concentration was calculated according to the regression equation, and the total flavonoid content of the sample was calculated according to formula (1) (1)…”

Section: Determination Of Total Flavone Contentmentioning

confidence: 99%

Preparation and Optimization of Physical and Chemical Properties of Chu Shizi Flavone Microcapsules

2023

MEDCM

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Chusizi has a long history as a traditional Chinese medicine, with clear effects, rich resources and low raw material price, which is suitable for large-scale production. In order to achieve protection and controlled release, microencapsulation technology is introduced to bury the small dispersed and reactive core wood flavone extract with natural or synthetic wall material. The bitterness of microencapsulated drugs is greatly reduced, and compared with ordinary drugs, microencapsulated drugs can reduce their own toxic and side effects, improve stability and reduce the amount of drugs. At the same concentration, the cytotoxicity of the drug after microencapsulation is significantly reduced, indicating that microencapsulation has a slow release effect on the drug and can improve the drug efficacy, so the Chu seed after microencapsulation is more beneficial to human body.

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Cinnamaldehyde microcapsules enhance bioavailability and regulate intestinal flora in mice

Cited by 9 publications

References 39 publications

Digestibility of Malondialdehyde-Induced Dietary Advanced Lipoxidation End Products and Their Effects on Hepatic Lipid Accumulation in Mice

Digestibility of Malondialdehyde-Induced Dietary Advanced Lipoxidation End Products and Their Effects on Hepatic Lipid Accumulation in Mice

Ligilactobacillus Salivarius improve body growth and anti-oxidation capacity of broiler chickens via regulation of the microbiota-gut-brain axis

Preparation and Optimization of Physical and Chemical Properties of Chu Shizi Flavone Microcapsules

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