Mechanisms underlying the wound healing and tissue regeneration properties of Chenopodium album

Abstract

In the current study, aerial parts (leaves, stem and shoots) of C. album were extracted with methanol and subjected to phytochemical and HPLC analysis. Agar well diffusion method was used for anti-bacterial activity against Gram-negative strains Escherichia coli, Salmonella typhi, Klebsiella, Pseudomonas aeruginosa and Gram-positive Bacillus cereus, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus. Burn was induced through flame heated metal rod on mice. C. album ointment (2% w/w), Vaseline (vehicle) and silver sulfadiazine (standard) were topically applied thrice daily for 15 days. Wound area was measured on day 0, 5, 10 and 15. On last day, the wound tissues were excised and subjected to histopathological, quantitative PCR and immunohistochemical analysis. Phenols, alkaloids, phytosterols, tannins, saponins, flavonoids, carbohydrates and glycosides were detected in phytochemical analysis. HPLC chromatogram displayed peaks for rutin, quercetin, ascorbic acid, gallic acid and various other phyto-constituents. The extract exhibited zone of inhibition in millimeter (mm) against E.

A review on antimicrobial activities of some culinary herbs and spices against Staphylococcus aureus

“…This plant is an annual herbaceous plant (with the local name of Sirken otu, Ak Kazayağı, Ak Sirken, Ak Pazı, Hoşkıran, Küllü ot, Yabani ıspanak) belongs to the Chenopodiaceae (Spinachaceae) family in Türkiye, which grows up to 150 to 200 cm (Atalay and Kamalak, 2019). Lambs quarter (English) and Bathu (Hindi) are the plant's known names around the world (Said et al, 2020). Chenopodiaceae family includes widely distributed more than 100 genera.…”

“…are cooked and consumed as a vegetable like spinach. It is also boiled and roasted (Kaya et al, 2004;Yadav et al, 2007;Said et al, 2020). Also, it can be consumed as a raw vegetable in salads or wraps (Yucel et al, 2018).…”

Rational selection of bioactive principles for wound healing applications: Growth factors and antioxidants

“…The five antioxidants inhibit transcription of pro‐inflammatory agents (eg, TNF‐α, IL‐1, IL‐6) via nuclear factor κβ (NF‐κβ) and exhibit well control of ROS on dysregulated inflammation of acute or chronic wounds 24,59 . Astaxanthin, EGCG, and curcumin inhibit NF‐κβ in the PDGF pathway in inflammatory cells improving chronic wound healing 60,61 . They are a promising treatment though at a specific concentration to enhance a cellular response 33 .…”

Changes of Mineralogical Properties and Biological Activities of Gypsum and Its Calcined Products with Different Phase Structures

“…e scald model was created using the method described by Said et al [15] with some modifications. For scald wound infliction, the animals were first anesthetized with pentobarbital sodium (50 mg/kg, b. w.), followed by removal of hairs from the dorsal area of mice using a hair trimmer.…”