Mechanisms underlying the vascular relaxation activities of Zingiber officinale var. rubrum in thoracic aorta of spontaneously hypertensive rats

Razali, Nadiah; Dewa, Aidiahmad; Asmawi, Mohd Zaini; Mohamed, Norita; Manshor, Nurul Maizan

doi:10.1016/j.joim.2019.12.003

Cited by 12 publications

(7 citation statements)

References 42 publications

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“…Concerns over the side effects and other adverse effects resulting from synthetic compounds in the treatment of BSS have been factors leading to medicinal plants as alternative choices. In view of the ability of DG extract can relax blood vessels by releasing nitric oxide and prostacyclin, activating cGMP‐KATP channels, muscarinic receptor stimulation, and transmembrane calcium channels or Ca 2+ release from intracellular storage, it is a treatment for BSS Good drug candidate (Razali et al., 2020).…”

Section: Resultsmentioning

confidence: 99%

Metabolomics study of dried ginger extract on serum and urine in blood stasis rats based on UPLC‐Q‐TOF/MS

Cao

Wang

et al. 2020

Food Science & Nutrition

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Section: Resultsmentioning

confidence: 99%

Metabolomics study of dried ginger extract on serum and urine in blood stasis rats based on UPLC‐Q‐TOF/MS

Cao

Wang

et al. 2020

Food Science & Nutrition

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“…In traditional medicine, it is used for treating headaches, indigestion, nausea, vomiting, and cancer. In addition, it is widely used to treat autoimmune diseases [ 7 ], hypertension [ 30 ], hypercholesteremia [ 31 ], hyperuricemia [ 32 ], bacterial infections [ 1 ], and cancer [ 1 ]. A summary of red ginger’s biological activities and molecular mechanisms is given in Table 2 .…”

Section: Biological Activities and Molecular Mechanisms Of Red Gingermentioning

confidence: 99%

“…Red ginger has been reported to reduce malondialdehyde levels in the liver and heart tissues, suggesting that the antihypertensive activity is mediated via inhibiting ACE and lipid peroxidation [ 52 ]. Razali et al [ 30 ] demonstrated the antihypertensive activity of red ginger in a SHR (spontaneously hypertensive rat) model. The mechanisms of vascular relaxation involve the release of nitric oxide and prostacyclin, the activation of cGMP-KATP channels, the stimulation of muscarinic receptors, and the stimulation of transmembrane calcium channel or Ca 2+ release from intracellular stores.…”

Section: Biological Activities and Molecular Mechanisms Of Red Gingermentioning

confidence: 99%

Zingiber officinale var. rubrum: Red Ginger’s Medicinal Uses

et al. 2022

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Zingiber officinale var. rubrum (red ginger) is widely used in traditional medicine in Asia. Unlike other gingers, it is not used as a spice in cuisines. To date, a total of 169 chemical constituents have been reported from red ginger. The constituents include vanilloids, monoterpenes, sesquiterpenes, diterpenes, flavonoids, amino acids, etc. Red ginger has many therapeutic roles in various diseases, including inflammatory diseases, vomiting, rubella, atherosclerosis, tuberculosis, growth disorders, and cancer. Scientific evidence suggests that red ginger exhibits immunomodulatory, antihypertensive, antihyperlipidemic, antihyperuricemic, antimicrobial, and cytotoxic activities. These biological activities are the underlying causes of red ginger’s therapeutic benefits. In addition, there have been few reports on adverse side effects of red ginger. This review aims to provide insights in terms the bioactive constituents and their biosynthesis, biological activities, molecular mechanisms, pharmacokinetics, and qualitative and quantitative analysis of red ginger.

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“…rubrum on vasodilation. It was determined that 6-gingerol, the main compound of Z. officinale Rosc, 82,83 reduced blood pressure and relaxed blood vessels by increasing NO production and cGMP-K ATP channel activation. 83…”

Section: Antihypertensive Effectsmentioning

confidence: 99%

Promising influences of gingerols against metabolic syndrome: A mechanistic review

2022

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Metabolic syndrome is an inflammatory disorder characterized by diabetes, obesity, atherosclerosis, and hypertension. Globally, this disease is increasing, especially in developed countries. Supposedly, herbal treatments for this disease likely have fewer adverse effects than chemical medications. Thus, they can be suitable options among the available chemical treatments. Ginger has been used as a spice and medicinal plant in traditional medicine and cooking. This herbal compound and its derivatives, such as 6‐gingerol, have shown promising effects on various molecular aspects of metabolic syndrome. In this study, we reviewed and discussed the significant impacts of gingerol, a derivative of ginger, on metabolic syndrome through various mechanisms. The benefits of 6‐gingerol include its effects on AMP‐activated protein kinase (AMPK), which prevent diabetes, lipid regulating effect (peroxisome proliferator‐activated receptors, PPARs), as well as its effects on enzymes and proteins preventing hyperlipidemia caused by a high‐fat diet. In addition, 6‐gingerol has anti‐atherosclerosis and anti‐hypertension effects through several molecular mechanisms. The current review will discuss various effects of 6‐gingerol on molecular pathways involved in diabetes, obesity, atherosclerosis, and hypertension as characterizing features of metabolic syndrome and suggests that 6‐gingerol can be a potential treatment agent for metabolic syndrome and shed light on a higher requirement for more pre‐clinical and clinical investigations.

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Mechanisms underlying the vascular relaxation activities of Zingiber officinale var. rubrum in thoracic aorta of spontaneously hypertensive rats

Cited by 12 publications

References 42 publications

Metabolomics study of dried ginger extract on serum and urine in blood stasis rats based on UPLC‐Q‐TOF/MS

Metabolomics study of dried ginger extract on serum and urine in blood stasis rats based on UPLC‐Q‐TOF/MS

Zingiber officinale var. rubrum: Red Ginger’s Medicinal Uses

Promising influences of gingerols against metabolic syndrome: A mechanistic review

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