Mechanisms Preserving Insulin Action during High Dietary Fat Intake

Lundsgaard, Anne‐Marie; Holm, Jacob Bak; Sjøberg, Kim A.; Bojsen‐Møller, Kirstine N.; Myrmel, Lene Secher; Fjære, Even; Jensen, Benjamin Anderschou Holbech; Nicolaisen, T; Hingst, Janne R.; Hansen, Sine L.; Doll, Sophia; Geyer, Philipp; Deshmukh, Atul S.; Holst, Jens J.; Madsen, Lise; Kristiansen, Karsten; Wojtaszewski, Jørgen F. P.

doi:10.1016/j.cmet.2018.08.022

Cited by 59 publications

(29 citation statements)

References 78 publications

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“…Our results from mice also demonstrate a greater fat mass loss during the intake of LF diets compared with HF/HP diets. Furthermore, our results from calorie restricted HF/HP-fed mice are in agreement with the recent finding that a HF intake (64E%) for 6 weeks does not impair insulin sensitivity in healthy, slightly overweight men in caloric balance [49].…”

Section: Discussionsupporting

confidence: 92%

The Impact of Different Animal-Derived Protein Sources on Adiposity and Glucose Homeostasis during Ad Libitum Feeding and Energy Restriction in Already Obese Mice

et al. 2019

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Low-fat diets and energy restriction are recommended to prevent obesity and to induce weight loss, but high-protein diets are popular alternatives. However, the importance of the protein source in obesity prevention and weight loss is unclear. The aim of this study was to investigate the ability of different animal protein sources to prevent or reverse obesity by using lean or obese C57BL/6J mice fed high-fat/high-protein or low-fat diets with casein, cod or pork as protein sources. Only the high-fat/high-protein casein-based diet completely prevented obesity development when fed to lean mice. In obese mice, ad libitum intake of a casein-based high-fat/high-protein diet modestly reduced body mass, whereas a pork-based high-fat/high-protein diet aggravated the obese state and reduced lean body mass. Caloric restriction of obese mice fed high-fat/high-protein diets reduced body weight and fat mass and improved glucose tolerance and insulin sensitivity, irrespective of the protein source. Finally, in obese mice, ad libitum intake of a low-fat diet stabilized body weight, reduced fat mass and increased lean body mass, with the highest loss of fat mass found in mice fed the casein-based diet. Combined with caloric restriction, the casein-based low-fat diet resulted in the highest loss of fat mass. Overall, the dietary protein source has greater impact in obesity prevention than obesity reversal.

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Section: Discussionsupporting

confidence: 92%

The Impact of Different Animal-Derived Protein Sources on Adiposity and Glucose Homeostasis during Ad Libitum Feeding and Energy Restriction in Already Obese Mice

et al. 2019

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“…The information about the composition of Tartary buckwheat (passed through a 80-120 mesh) used in the diet of HFDB was as follows: 2.74% rutin, 0.08% quercetin, 53.4% starch, 1.74% fiber, 16.4% protein, and 4.2% fat.Figures 1 and 2 show that after 12 weeks of high-fat feeding, the body weight, and serum TC and TG of HFD rats did not increase compared with the control group. In contrast, TC values of HFD, HFDQ, HFDR, and HFDB groups were lower than that in the control group, agreeing withLundsgaard et al, where HFD feeding lowered the TG content in mice and humans(Lundsgaard et al, 2019). HDL and LDL did not change significantly.…”

supporting

confidence: 89%

Effect of tartary buckwheat, rutin, and quercetin on lipid metabolism in rats during high dietary fat intake

Peng

Zhang

et al. 2019

Food Science & Nutrition

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Tartary buckwheat is rich in flavonoids. However, the health‐promoting effect of these flavonoids has not been adequately studied. In the present study, we investigated the impact of rutin, quercetin, and Tartary buckwheat on the lipid metabolism of rats on a high‐fat diet. Quercetin could significantly reduce body weight, serum triacylglycerol, low‐density lipoprotein cholesterol, TNF‐α, insulin, and ameliorate glucose tolerance. It was surprising that Tartary buckwheat significantly increased the weight of the rats. Rutin, quercetin, and Tartary buckwheat tended to decreased fat deposition in the liver of rats but have little effect on short‐chain fatty acid production. The changes in the structure and diversity of the microbiota were found to be modulated by these diets. It was concluded that quercetin could attenuate high‐fat diet‐induced obesity, rutin, quercetin, and Tartary buckwheat can shape the specific structure of gut microbiota. Mechanism of Tartary buckwheat on lipid metabolism needs further systematic research.

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“…More recent study showed that people having diets comprised 64E% fat, 16E% protein, and 20E% carbohydrate for 6 weeks with stable body weight, insulin/glucosehomeostasis in the fasting state was changed in a non-diabetic direction, as fasting plasma insulin concentration decreased after high-fat diets. Same results were obtained by saturated and unsaturated fats 24 .…”

Section: Mellitussupporting

confidence: 77%

Are mice born normally with an egg-only diet?

Isobe

Sato²,

Ono³

et al. 2020

Preprint

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Chicken eggs (egg) contain high amounts of important proteins and fat with a very low amount of 2 carbohydrates, and also contain all vitamins and minerals needed for the chick to develop. We mated 8-week-old mice consuming an egg-only diet, and examined whether mice got pregnant and mice gave birth. Then we continued to raise newborn mice only consuming an egg-only diet compared to normal chew diet. We found that the rate of pregnancy of the mice consuming an egg-only diet was not different from that of the mice consuming normal chew diet. Further, we found that the number of pupus born from the mother consuming only eggs was not different from that of the mother consuming normal chew diet. However, the newborn mice from the mother fed only eggs did not grow healthy when they consume egg-only diet. Only few mice were alive at one month after birth. Then we change the diet just before or just after birth from egg only diet to normal chew diet and we found that both group grew healthy more than one month. These results indicate that mice are born healthy only with egg only diet.

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Mechanisms Preserving Insulin Action during High Dietary Fat Intake

Cited by 59 publications

References 78 publications

The Impact of Different Animal-Derived Protein Sources on Adiposity and Glucose Homeostasis during Ad Libitum Feeding and Energy Restriction in Already Obese Mice

The Impact of Different Animal-Derived Protein Sources on Adiposity and Glucose Homeostasis during Ad Libitum Feeding and Energy Restriction in Already Obese Mice

Effect of tartary buckwheat, rutin, and quercetin on lipid metabolism in rats during high dietary fat intake

Are mice born normally with an egg-only diet?

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