Effect of tartary buckwheat, rutin, and quercetin on lipid metabolism in rats during high dietary fat intake

Peng, Lianxin; Qu, Zhang; Zhang, Yanhong; Yao, Zhendong; Song, Panpan; Wei, Lidong; Zhao, Gang; Yan, Zhuyun

doi:10.1002/fsn3.1291

Cited by 55 publications

(48 citation statements)

References 46 publications

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“…The anti-obesity effects of rutin, including weight loss, decreased adipose tissue weight, and reduced blood lipid concentrations have been reported by Hsu et al [ 22 ]. Another study showed that quercetin significantly decreased body weight, perirenal fat, and epididymis fat compared with HFD, but rutin showed no effect on this basis [ 23 ]. The inconsistent effect of rutin may be explained by the different dose, background diet, animal model, and duration of supplementation.…”

Section: Resultsmentioning

confidence: 99%

“…High levels of CREA in the bloodstream could be an indicator of kidney disease. A previous study showed that an HFD increased the CREA level [ 23 ]. In the results, there was no difference between ND and HFD groups in terms of CREA levels, and the administration of R, AR, and Q decreased the CREA levels compared with the HFD.…”

Section: Resultsmentioning

confidence: 99%

“…In a previous study, it was reported that suppression of TG absorption has a prominent role in weight loss [ 29 ]. In addition, a previous report has indicated that quercetin significantly decreased TG and LDL-c; however, rutin did not affect the levels of lipid metabolism parameters [ 23 ]. In this study, the administration of AR or Q was effective in lowering TG and LDL-c in vivo, and these results are also consistent with the previous study.…”

Section: Resultsmentioning

confidence: 99%

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Effect of Deglycosylated Rutin by Acid Hydrolysis on Obesity and Hyperlipidemia in High-Fat Diet-Induced Obese Mice

2020

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The present study evaluated the effects of acid-treated rutin on hyperlipidemia and obesity in high-fat diet (HFD)-induced obese mice. The mice consumed a HFD with or without acid-treated rutin for 7 weeks. Body weight gain considerably decreased, by approximately 33%, in the acid-treated rutin (AR) and quercetin (Q) groups compared to that in the HFD group. The adipocytes’ size in epididymal fat in AR and Q groups was significantly reduced compared to that in the HFD group (p < 0.05). Treatment with AR decreased the levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol compared to the HFD group. In particular, administration of AR significantly decreased serum triglyceride (36.82 mg/dL) by 46% compared to HFD (69.30 mg/dL). The AR group also showed significantly decreased atherogenic indices and cardiac risk factors. These results suggest that deglycosylated rutin generated by acid treatment enhances the anti-obesity and hypolipidemic effects in obese mice, and provides valuable information for improving the functional properties of glycosidic flavonoids.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effect of Deglycosylated Rutin by Acid Hydrolysis on Obesity and Hyperlipidemia in High-Fat Diet-Induced Obese Mice

2020

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“…Rutin has been shown not to affect serum TC (51), ALT, and AST (52) in high-fat diet-fed rats. In addition, rutin has little effect on SCFA production (51). However, significant reductions in the serum TC and LDL-c levels of patients with type 2 diabetes were observed in the tartary buckwheat intervention group (6).…”

Section: Discussionmentioning

confidence: 94%

Anti-diabetic effects of the soluble dietary fiber from tartary buckwheat bran in diabetic mice and their potential mechanisms

Wu¹,

Qin

et al. 2021

Food & Nutrition Research

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Background: Tartary buckwheat has beneficial effects on glucose and lipid metabolism of patients with type 2 diabetes mellitus. However, the physiological effects of a soluble dietary fiber (SDF) from tartary buckwheat have rarely been studied, especially in vivo. Objective: This study aimed to examine the hypoglycemic and hypolipidemic effects of SDF from tartary buckwheat bran on high-fat diet/streptozotocin-induced diabetic mice. Design: The SDF of tartary buckwheat bran was collected according to the Association of Official Analytical Chemists method 991.43. Diabetic mice were treated with high-fat diets supplemented with 0.5, 1, and 2% SDF for 8 weeks. Parameters related to glucose and lipid metabolism and relevant mechanisms, including the excretion of short-chain fatty acids and the glycemic signaling pathway in the liver, were investigated. In addition, the structural characterization of a purified polysaccharide from SDF of tartary buckwheat bran was illustrated. Result: Supplementation with SDF in the diet resulted in reduced levels of fasting blood glucose, improved oral glucose tolerance, increased levels of liver glycogen and insulin, as well as improved lipid profiles in both the serum and liver, in diabetic mice. The amelioration of glucose and lipid metabolism by SDF was accompanied by an increase in the short-chain fatty acid levels in the cecum and co-regulated by hepatic adenosine-5′-monophosphate-activated protein kinase (AMPK) phosphorylation. A neutral tartary buckwheat polysaccharide with an average molecular weight of 19.6 kDa was purified from the SDF, which consisted mainly of glucose with α-glycosidic bonds. Conclusions: The SDF of tartary buckwheat bran exhibits hypoglycemic and hypolipidemic effects in diabetic mice, contributing to the anti-diabetic mechanisms of tartary buckwheat.

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“…It was reported that they are hydrolyzed to their aglycone forms in the small or large intestine by intestinal bacterial glycosidase, resulting in several types of metabolites, such as glucuronides, sulfate conjugates, and methylated compounds [ 21 , 22 ]. A few studies were carried out to determine the in vivo effects of TB extracts on hyperlipidemia, obesity, hypertension, and inflammatory liver injury in rats [ 23 , 24 , 25 , 26 ]. Recently, the pharmacokinetics and associated metabolites of TB extracts were evaluated in beagle dogs following a single-dose co-administration with ethanol; however, the in vivo functional activity in alcoholic liver disease (ALD) was not demonstrated [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and Protective Effects of Tartary Buckwheat Flour Extracts against Ethanol-Induced Liver Injury in Rats

2020

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The grains of Tartary buckwheat (Fagopyrum esculentum) are traditionally consumed on a daily basis and are used in the preparation of diverse processed foods owing to the high concentration of rutin, an antioxidant compound. However, rutin is highly concentrated in hull and bran, but not in edible flour fractions. Rutin-enriched TB flour extracts (TBFEs) were obtained by hydrothermal treatment (autoclaving, boiling, or steaming) and their pharmacokinetic profiles were evaluated following a single-dose oral administration in rats. The antioxidant and protective activities of the extracts against alcoholic liver disease (ALD) were investigated after repetitive oral administration of TBFEs for 28 days prior to ethanol ingestion. The results demonstrated that rutin-enriched TBFEs had better oral absorption and was retained longer in the bloodstream than native TBFE or standard rutin. The activities of antioxidant enzymes and intracellular antioxidant levels increased in ALD rats following TBFE treatments, especially following the administration of rutin-enriched TBFEs. The antioxidant activity of TBFEs consequently contributed toward protecting the liver against injury caused by repetitive ethanol administration, as confirmed by analyzing relative liver weight, liver injury markers, lipid peroxidation, and calcium permeability. These results suggest the promising potential of TBFEs as antioxidant-enriched functional foods for human health.

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Effect of tartary buckwheat, rutin, and quercetin on lipid metabolism in rats during high dietary fat intake

Cited by 55 publications

References 46 publications

Effect of Deglycosylated Rutin by Acid Hydrolysis on Obesity and Hyperlipidemia in High-Fat Diet-Induced Obese Mice

Effect of Deglycosylated Rutin by Acid Hydrolysis on Obesity and Hyperlipidemia in High-Fat Diet-Induced Obese Mice

Anti-diabetic effects of the soluble dietary fiber from tartary buckwheat bran in diabetic mice and their potential mechanisms

Pharmacokinetics and Protective Effects of Tartary Buckwheat Flour Extracts against Ethanol-Induced Liver Injury in Rats

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