Effect of Deglycosylated Rutin by Acid Hydrolysis on Obesity and Hyperlipidemia in High-Fat Diet-Induced Obese Mice

Abstract

The present study evaluated the effects of acid-treated rutin on hyperlipidemia and obesity in high-fat diet (HFD)-induced obese mice. The mice consumed a HFD with or without acid-treated rutin for 7 weeks. Body weight gain considerably decreased, by approximately 33%, in the acid-treated rutin (AR) and quercetin (Q) groups compared to that in the HFD group. The adipocytes’ size in epididymal fat in AR and Q groups was significantly reduced compared to that in the HFD group (p < 0.05). Treatment with AR decreased the levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol compared to the HFD group. In particular, administration of AR significantly decreased serum triglyceride (36.82 mg/dL) by 46% compared to HFD (69.30 mg/dL). The AR group also showed significantly decreased atherogenic indices and cardiac risk factors. These results suggest that deglycosylated rutin generated by acid treatment enhances the anti-obesity and hypolipidemic effects in obese mice, and provides valuable information for improving the functional properties of glycosidic flavonoids.

Maternal Quercetin Consumption during Pregnancy May Help Regulate Total Cholesterol/HDL-Cholesterol Ratio without Effect on Cholesterol Levels in Male Progeny Consuming High-Fat Diet

“…The C-HF group consumed less food on a gram-per-gram basis but a similar amount of overall energy compared with the C-C group ( Table 3 ). Similar HF diet–induced obesity has been reported in mice models previously [ 9 , 30 ]. Maternal quercetin consumption (Q-HF) accelerated the HF-diet–induced weight gain compared with mice in the C-HF group, which had a similar food intake.…”

“…Male mice are recognized to be more likely to become obese than female mice, and that the protection against obesity in female mice is eliminated by ovariectomy, indicating that there are metabolic differences between males and females [ 29 ]. However, many research groups, including us, have employed male mice, and evaluate the functional aspects of quercetin [ 9 , 11 , 12 ]. Therefore, we firstly focused on the male progeny, and evaluated the effects of maternal quercetin consumption during pregnancy on high-fat diet–induced obesity.…”

“…On the other hand, studies have reported that many foods contain ingredients with no nutritional value that protect against obesity by inhibiting lipid absorption and accumulation or promoting energy combustion. One of these ingredients, quercetin (and its glucosides, which are major flavonoids) is considered a candidate for combatting obesity, as it was recently reported to exhibit anti-obesity activity and to regulate lipid metabolism using mice models [ 9 , 10 , 11 ]. Our group has also demonstrated that the quercetin glucoside, monoglucosyl rutin, has anti-obesity effects using mice models [ 12 ].…”

The Effect of Ellagic Acid on Hepatic Lipid Metabolism and Antioxidant Activity in Mice

“…Dyslipidemia is often manifested as a variation of hyperlipidemia indicators, such as serum TC, TG, abnormal elevation of LDL-C, or abnormal reduction of HDL-C (Tietge, 2014). Hyperlipidemia is not only the causative factor for many cardiovascular diseases, such as atherosclerosis, coronary artery disease, and myocardial infarction but also closely related to obesity, fatty liver, hypertension, and hyperglycemia (Alloubani et al, 2020;Yang et al, 2020). Hence, maintaining the balance of lipid metabolism is vital to the health of animals and humans.…”

Enteromorpha prolifera polysaccharide prevents high‐ fat diet‐induced obesity in hamsters: A NMR‐based metabolomic evaluation

“…Metabolic syndrome is closely related to several chronic diseases including obesity, dyslipidemia, diabetes mellitus and cardiovascular diseases (J. Yang et al., 2020). Obesity is a serious problem caused by an imbalance between energy intake and energy consumption (Arika et al., 2019).…”