Mechanisms of vasorelaxation induced by Ziziphora clinopodioides Lam. (Lamiaceae) extract in rat thoracic aorta

Sénejoux, François; Girard, Christian; Kerram, Parhat; Aisa, Haji Akber; Berthelot, Alain; Bévalot, Françoise; Demougeot, Céline

doi:10.1016/j.jep.2010.08.028

Cited by 41 publications

(24 citation statements)

References 23 publications

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“…The rings were pre-incubated with 1 mM of TEA (nonselective calcium-activated K + channel blocker), 1 mM of 4-AP (voltage-dependent K + channel blocker), 10 μM of BaCl 2 (inwardly rectifying K + channel blocker) or 10 μM of glibenclamide (non-specific ATP-sensitive K + channel blocker) was applied to the endothelium-intact aorta rings for 20 min prior to pre-contraction by PE (Senejoux et al, 2010).…”

Section: Aortic Ring Preparation and Vasorelaxation Studymentioning

confidence: 99%

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Mechanism of vasorelaxation induced by eupatorin in the rats aortic ring

Yam

Tan

Ahmad

et al. 2016

European Journal of Pharmacology

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Section: Aortic Ring Preparation and Vasorelaxation Studymentioning

confidence: 99%

“…Eupatorin (0.036, 0.145 and 0.58 µM in organ bath) was used to pre-incubate the aortic rings for 20 min before PE (1 µM) was added. The group without incubation of eupatorin was considered to be the control group (Senejoux et al, 2010).…”

Section: Aortic Ring Preparation and Vasorelaxation Studymentioning

confidence: 99%

Mechanism of vasorelaxation induced by eupatorin in the rats aortic ring

Yam

Tan

Ahmad

et al. 2016

European Journal of Pharmacology

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“…The stereochemistry of monoterpenic glucosides is important for this effect according to these results [4]. Vasorelaxant activity was shown by those Z. clinopodioides extracts that had high concentration of polyphenolic substances [135]. The mechanism of its vasorelaxant action was also elucidated.…”

Section: Omementioning

confidence: 92%

Kazakh Ziziphora Species as Sources of Bioactive Substances

et al. 2016

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Ziziphora species represent the prototypical example of the Lamiaceae family. The phytochemicals present in Ziziphora include monoterpenic essential oils, triterpenes and phenolic substances belonging to the flavonoids. In Kazakh traditional medicine, Ziziphora species possess several medicinal uses. In particular, Z. bungeana Lam. and Z. clinopodioides Lam. are used for the treatment of illnesses related to the cardiovascular system or to combat different infections. Unfortunately, the majority of the information about the complex Ziziphora species is only available in Russian and Chinese language, therefore, we decided gather all available information on Kazakhstan Ziziphora, namely its content compounds, medicinal uses and published patents, to draw the attention of scientists to this very interesting plant with high medicinal potential.

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“…They are frequently prescribed as infusions for various purposes such as powerful aperitif, sedative, stomachic carminative and antiseptic agents 3 . Different species of Ziziphora are also used to treat gastrointestinal disorders, hypertension, fever, edema, heart disease, insomnia, lung disease and hemorrhoids in China 4 and for wound healing in Turkey 3 .…”

Section: Introductionmentioning

confidence: 99%

Gas Chromatographic-Mass Spectrometric Analysis of Volatiles Obtained by HS-SPME-GC-MS Technique from Aerial Parts of Ziziphora Capitata L., and Evaluation for Biological Activity.

Mohammadhosseini¹,

Akbarzadeh²,

Hashemi‐Moghaddam³

et al. 2016

Orient. J. Chem

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Volatile constituent components from aerial parts of Ziziphora capitata L. were successfully separated using headspace solid-phase microextraction (HS-SPME) approach, and were subsequently analyzed by means of GC and GC-MS instruments. The major volatile compounds were found to be pulegone (23.8%), p-mentha-3,8-diene (17.0%), a-pinene (11.4%), b-pinene (11.3%) and p-menth-3-en-8-ol (8.3%) altogether involving more than 70% of the profile accounting for high frequency of monoterpene hydrocarbons. Moreover, the methanolic extracts of Z. capitata were evaluated for possible antioxidant and antibacterial activities. In this regard, antioxidant activity of the extracts was determined by monitoring the scavenging capability of the DPPH free radical. Antibacterial activity was evaluated against some of Gram-positive and Gram-negative bacteria using disc diffusion and broth microdilution methods. The minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values varied over the ranges 3.12-12.5 mg/ml and 6.25-25 mg/ml, respectively. Our study revealed that methanolic extracts of Z. capitata exhibit strong and promising broad-spectrum activities against all the test isolates. For clinical isolates, the minimal MIC and MBC values were related to B. cereus and L. monocytogenes strains, whereas for the standard strains, both P. aeruginosa and S. aureus showed the lowest MIC and MBC values under the same conditions.

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Mechanisms of vasorelaxation induced by Ziziphora clinopodioides Lam. (Lamiaceae) extract in rat thoracic aorta

Cited by 41 publications

References 23 publications

Mechanism of vasorelaxation induced by eupatorin in the rats aortic ring

Mechanism of vasorelaxation induced by eupatorin in the rats aortic ring

Kazakh Ziziphora Species as Sources of Bioactive Substances

Gas Chromatographic-Mass Spectrometric Analysis of Volatiles Obtained by HS-SPME-GC-MS Technique from Aerial Parts of Ziziphora Capitata L., and Evaluation for Biological Activity.

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