Mechanisms of uterine contractility in laying hens

Kupittayanant, Sajeera; Kupittayanant, P.; Suwannachat, C.

doi:10.1016/j.anireprosci.2008.10.020

Cited by 12 publications

(9 citation statements)

References 21 publications

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“…This includes the PGF2α receptor; which was found to mediate uterine contraction in the laying hens via inducing the influx of extracellular Ca 2+ [49]. Our finding has shown that administration of thapsigargin, a SERCA inhibitor resulted in a slight but significant increase in the Emax induced by oxytocin and FDA.…”

Section: Discussionmentioning

confidence: 70%

In-Vitro effect of Ficus deltoidea on the contraction of isolated rat’s uteri is mediated via multiple receptors binding and is dependent on extracellular calcium

Salleh

Ahmad

2013

BMC Complement Altern Med

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BackgroundFicus deltoidea, is a perennial herb that is used to assist labor, firm the uterus post-delivery and to prevent postpartum bleeding. In view of its claimed uterotonic action, the mechanisms underlying plant’s effect on uterine contraction were investigated.MethodsAdult female SD rats were injected with 2 mg/kg 17β-oestradiol (E2) to synchronize their oestrous cycle. A day after injection, uteri were removed for in-vitro contraction studies. The dose dependent effect of Ficus deltoidea aqeous extract (FDA) on the tension produced by the isolated rat’s uteri was determined. The effects of atropine (2×10-8 M), atosiban (0.5 IU), THG113.31 (10 μM), oxodipine (0.25 mM), EDTA (1 mM), 2-amino-ethoxy-diphenylborate (2-APB) (40 mM) and thapsigargin (1 mM) on the maximum force of contraction (Emax) achieved following 2 mg/ml FDA administration were also investigated.ResultsFDA induced in-vitro contraction of the isolated rat’s uteri in a dose-dependent manner. Administration of atropine, atosiban and THG113.31 reduced the Emax with atosiban having the greatest effect. The Emax was also reduced following oxodipine and EDTA administration. There was no significant change observed following 2-APB administration. Thapsigargin, however, augmented Emax.ConclusionsFDA-induced contraction of the isolated rat’s uteri is mediated via multiple uterotonin receptors (muscarinic, oxytocin and prostaglandin F2α) and was dependent on the extracellular Ca2+. Contraction, however, was not dependent on the Ca2+ release from the internal stores. This in-vitro study provides the first scientific evidence on the claimed effect of Ficus Deltoidea on uterine contraction.

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Section: Discussionmentioning

confidence: 70%

In-Vitro effect of Ficus deltoidea on the contraction of isolated rat’s uteri is mediated via multiple receptors binding and is dependent on extracellular calcium

Salleh

Ahmad

2013

BMC Complement Altern Med

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“…The potential candidate gene CALM1 for EN21-40 on GGA5 is a prototypical calcium sensor [ 46 ]. Calcium is known to be involved in the regulation of theca cell androstenedione production and uterine contractility in laying hens [ 47 , 48 ], which have the direct effect on the egg production. In a recent study, CALM1 was found to be highly expressed in the ovary of the laying geese [ 49 ] implied that CALM1 might be involved with the process of egg laying.…”

Section: Discussionmentioning

confidence: 99%

Identification of Promising Mutants Associated with Egg Production Traits Revealed by Genome-Wide Association Study

et al. 2015

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Egg number (EN), egg laying rate (LR) and age at first egg (AFE) are important production traits related to egg production in poultry industry. To better understand the knowledge of genetic architecture of dynamic EN during the whole laying cycle and provide the precise positions of associated variants for EN, LR and AFE, laying records from 21 to 72 weeks of age were collected individually for 1,534 F2 hens produced by reciprocal crosses between White Leghorn and Dongxiang Blue-shelled chicken, and their genotypes were assayed by chicken 600 K Affymetrix high density genotyping arrays. Subsequently, pedigree and SNP-based genetic parameters were estimated and a genome-wide association study (GWAS) was conducted on EN, LR and AFE. The heritability estimates were similar between pedigree and SNP-based estimates varying from 0.17 to 0.36. In the GWA analysis, we identified nine genome-wide significant loci associated with EN of the laying periods from 21 to 26 weeks, 27 to 36 weeks and 37 to 72 weeks. Analysis of GTF2A1 and CLSPN suggested that they influenced the function of ovary and uterus, and may be considered as relevant candidates. The identified SNP rs314448799 for accumulative EN from 21 to 40 weeks on chromosome 5 created phenotypic differences of 6.86 eggs between two homozygous genotypes, which could be potentially applied to the molecular breeding for EN selection. Moreover, our finding showed that LR was a moderate polygenic trait. The suggestive significant region on chromosome 16 for AFE suggested the relationship between sex maturity and immune in the current population. The present study comprehensively evaluates the role of genetic variants in the development of egg laying. The findings will be helpful to investigation of causative genes function and future marker-assisted selection and genomic selection in chickens.

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“…PGF 2α can be produced directly from PGH 2 (Kabututu et al, 2009) or from PGE 2 (Phillips et al, 2011). PGF 2α induces oviposition in oviparous reptiles (Guillette Jr. et al, 1991;Hargrove and Ottinger, 1992;Kupittayanant et al, 2009), and elicits myometrial contractions during labor in viviparous mammals (Karim, 1968;Challis et al, 2000;McKeown et al, 2000). PGF 2α binds to the prostaglandin F receptor, whose activation leads to release of intracellular calcium which in turn binds calmodulin; calcium-calmodulin then activates myosin light chain kinase to phosphorylate myosin light chains and cause muscle contraction .…”

Section: Inflammation At Parturitionmentioning

confidence: 99%

Cooperative inflammation: The recruitment of inflammatory signaling in marsupial and eutherian pregnancy

Stadtmauer

Wagner

2020

Journal of Reproductive Immunology

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The evolution of viviparity in therian mammals, i.e. marsupials and "placental" mammals, occurred by retention of the conceptus in the female reproductive tract and precocious "hatching" from the shell coat. Both eutherian embryo implantation and the opossum embryo attachment reaction are evolutionarily derived from and homologous to a defensive inflammatory process induced after shell coat hatching. However, both lineages, marsupials and placental mammals, have modified the inflammatory response substantially. We review the induction, maintenance, and effects of inflammation throughout pregnancy, with special attention to the role of prostaglandins and the mucosal inflammatory response, both of which likely had roles in early mammalian viviparity. We propose that the key step was not only suppression of the inflammatory response after implantation in placental mammals, but also the transfer of the inflammatory cell-cell communication network to a different set of cell types than in generic inflammation. To support this conclusion we discuss evidence that pro-inflammatory signal production in the opossum is not limited to maternal cells, as expected in bona fide defensive inflammation, but also includes fetal tissues, in a process we term cooperative inflammation. The ways in which the inflammatory reaction was independently modified in these two lineages helps explain major life history differences between extant marsupials and eutherians.

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Mechanisms of uterine contractility in laying hens

Cited by 12 publications

References 21 publications

In-Vitro effect of Ficus deltoidea on the contraction of isolated rat’s uteri is mediated via multiple receptors binding and is dependent on extracellular calcium

In-Vitro effect of Ficus deltoidea on the contraction of isolated rat’s uteri is mediated via multiple receptors binding and is dependent on extracellular calcium

Identification of Promising Mutants Associated with Egg Production Traits Revealed by Genome-Wide Association Study

Cooperative inflammation: The recruitment of inflammatory signaling in marsupial and eutherian pregnancy

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