Mechanisms of the Modulation of Pacemaker Activity by GnRH Peptides in the Terminal Nerve-GnRH Neurons

Abe, Hideki; Oka, Yoshitaka

doi:10.2108/zsj.19.111

Cited by 28 publications

(18 citation statements)

References 70 publications

(73 reference statements)

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“…Interesting questions for future studies are whether modulation of this conductance underlies intrinsic changes in interburst intervals within the same GnRH neuron, which have been observed in longer recordings [102], and whether neuromodulators induce changes in this conductance or an intrinsic cycle in the GnRH neuron (Figure 1D, E). Of interest, GnRH iteslf alters pacemaking of teleost terminal nerve GnRH neurons in part via altering calcium-activated potassium and calcium conductances [2]. …”

Section: Intrinsic Properties Of Gnrh Neuronsmentioning

confidence: 99%

Identified GnRH neuron electrophysiology: A decade of study

Moenter¹

2010

Brain Research

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Over the past decade, the existence of transgenic mouse models in which reporter genes are expressed under control of the gonadotropin-releasing hormone (GnRH) promoter has made possible the electrophysiological study of these cells. Here we review the intrinsic and synaptic properties of these cells that have been revealed by these approaches, with a particular regard to burst generation. Advances in our understanding of neuromodulation of GnRH neurons and synchronization of this network are also discussed.

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Section: Intrinsic Properties Of Gnrh Neuronsmentioning

confidence: 99%

Identified GnRH neuron electrophysiology: A decade of study

Moenter¹

2010

Brain Research

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“…The TN-GnRH neurons are controlled in an autocrine/ paracrine manner by the GnRH peptide synthesized and released from the TN-GnRH neurons themselves, which results in the synchronized positive feedback facilitation of multiple GnRH neurons (3,4,34). Thus, the TN-GnRH neurons of the dwarf gourami form a functionally coordinated cluster via diffusional signal (auto/paracrine regulation by GnRH) as well as the electrotonic and metabolic coupling via the gap junctional communications.…”

Section: Gap Junctions For the Communication Of Cytoplasmic Signalingmentioning

confidence: 99%

Coordinated Synchronization in the Electrically Coupled Network of Terminal Nerve Gonadotropin-Releasing Hormone Neurons as Demonstrated by Double Patch-Clamp Study

Haneda

Oka

2008

Endocrinology

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The peptidergic neurons play important roles such as neuromodulatory and neuroendocrine functions in the central nervous system. However, our knowledge about the organization and the function of the peptidergic neuromodulator systems is still very poor. The terminal nerve GnRH peptidergic neurons of a teleost, the dwarf gourami (Colisa lalia), serve as an excellent model system for such study. The cell bodies are large and make up a tight cell cluster, and the easy access to the cell bodies on the ventral surface of the brain makes the electrophysiological measurements in a precisely controlled manner. Here we show direct evidence to demonstrate the electrical coupling and the synchronization of the neural firing activity among the terminal nerve GnRH neurons by using the double patch-clamp recording technique. The electrical coupling coefficient was strong enough (ranged from 0.083 to 0.370) to synchronize spontaneous firings of GnRH neurons in the cluster. A model, in which the firings in the cluster occur within a small time window (dozens of milliseconds), was verified by using the serial loose-seal extracellular patch-clamp recordings and the cross-correlogram analysis. The present findings provide several insights for understanding the physiological mechanisms and functional significance of synchronized activities in the peptidergic and/or aminergic neuromodulator system as well as in the peptidergic neuroendocrine cells.

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“…In contrast to the well-established roles of GnRH1 neurons on the reproductive endocrine axis, functional effects of the extrahypothalamic GnRH2/3 systems are less understood. Yet, widespread projection of the TN-GnRH3 networks throughout the central nervous system (Abraham et al, 2008;Xia et al, 2014), their intrinsic pacemaker activity (Abe and Oka, 2000;Kanda et al, 2010) and their autocrine/paracrine regulation of spontaneous firing (Abe and Oka, 2002;Karigo and Oka, 2013) suggest important biological roles.…”

Section: Introductionmentioning

confidence: 99%