Low dose exposure to Bisphenol A alters development of gonadotropin-releasing hormone 3 neurons and larval locomotor behavior in Japanese Medaka

Inagaki, Tomoko; Smith, Natalie; Lee, Eric; Ramakrishnan, Siddharth

doi:10.1016/j.neuro.2015.12.003

Cited by 27 publications

(16 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is consistent with the observed lack of behavioral impairment in the intertidal gastropod Littorina littorea; as PP20 leachates impaired their chemosensory ability without impacting their neuromuscular abilities (Seuront, 2018). In turn, our results contrast with previous evidence that PP-plasticizers reduce fish larvae velocity in the first days after hatching (Inagaki et al, 2016;Wang et al, 2013) and negatively impact adult-fish locomotion and reproductive behavior after at least 2 months of exposure (Gray et al, 1999;Xia et al, 2010). Note that the apparent discrepancy observed between the aforementioned studies and our experiment might be due to differences in exposure duration as reported in Table 2.…”

Section: Discussionsupporting

confidence: 90%

Motion behavior and metabolic response to microplastic leachates in the benthic foraminifera Haynesina germanica

Langlet

Bouchet

Delaeter

et al. 2020

Journal of Experimental Marine Biology and Ecology

View full text Add to dashboard Cite

Plastic is one of the major sources of pollution in modern oceans. When in seawater, toxic plasticizers (the additives incorporated in plastic polymers during manufacturing processes) typically diffuse and accumulate in sediments and in benthic and pelagic organisms' tissues. These plastic leachates affect survival, behavior and metabolism of various marine metazoans, but little effort was placed in studying their effect on protists. In this contribution we monitored the short-term effect of polypropylene (PP) leachates at both environmentally realistic and chronic concentrations on Haynesina germanica locomotion and metabolism. We found that PP leachates has no lethal nor effects on this species activity. Taken together, these results suggest that benthic foraminifera may be more resistant than marine metazoans to plasticizers pollutants.

show abstract

Section: Discussionsupporting

confidence: 90%

Motion behavior and metabolic response to microplastic leachates in the benthic foraminifera Haynesina germanica

Langlet

Bouchet

Delaeter

et al. 2020

Journal of Experimental Marine Biology and Ecology

View full text Add to dashboard Cite

show abstract

“…Acetone was purchased from Lingfeng Chemical Reagent Co. Ltd. (Shanghai, China) and acetone was the vehicle for E2 and BPA. Serial concentrations of E2 (500ng/L and 2000ng/L) and BPA (200μg/L and 2000μg/L) were used for pre-trial[ 18 , 19 ]. Because of the pre-trial data ( S1 Fig ) and the short exposing time (5 weeks in the present study) compared with the long exposing time in natural water, BPA at 2000μg/L and E2 at 2000ng/L were selected for subsequent experiments.…”

Section: Methodsmentioning

confidence: 99%

Influence of Endogenous and Exogenous Estrogenic Endocrine on Intestinal Microbiota in Zebrafish

Liu¹,

Yao²,

Li³

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

Gender is one of the factors influencing the intestinal microbial composition in mammals, but whether fish also have gender-specific intestinal microbial patterns remains unknown. In this decade, endocrine disrupting chemicals in surface and ground water of many areas and increasing observation of freshwater male fish displaying female sexual characteristics have been reported. Here we identified the difference in intestinal microbiota between male and female zebrafish, and revealed the influence of endocrine disrupting chemicals on zebrafish intestinal microbiota by using high-throughput sequencing. The results indicated that Fusobacteria, Bacteroidetes and Proteobacteria were dominant in the gut of zebrafish and there were no obvious gender-specific intestinal microbial patterns. Two endocrine disrupting chemicals, Estradiol (E2) and Bisphenol A (BPA), were selected to treat male zebrafish for 5 weeks. E2 and BPA increased vitellogenin expression in the liver of male zebrafish and altered the intestinal microbial composition with the abundance of the phylum CKC4 increased significantly. Our results suggested that because of the developmental character and living environment, gender did not influence the assembly of intestinal microbiota in zebrafish as it does in mammals, but exposure extra to endocrine disrupting chemicals disturbed the intestinal microbial composition, which may be related to changes in host physiological metabolism.

show abstract

“…Moreover, impaired embryonic development could be related to endocrine disruptor compounds. For instance, some of EDCs exhibit a genotoxic potential in aquatic invertebrates, which could partly explain the observed developmental defects and genotoxicity in fish embryos in this study, but these compounds remained to be identified [35] [36]. In the present study, the use of in vitro assays allowed to quantify estrogenic, androgenic or glucocorticoid activities of effluents and highlighted their removal through tertiary treatment.…”

Section: Discussionmentioning

confidence: 83%

Assessment of Ozone or Not-Treated Wastewater Ecotoxicity Using Mechanism-Based and Zebrafish Embryo Bioassays

Wigh¹,

Aı̈t-Aı̈ssa²,

Creusot³

et al. 2018

JEP

View full text Add to dashboard Cite

Toxicity of wastewater treatment plant (WWTP) effluents is usually assessed with standardized bioassays, as e.g. the Fish Embryo Toxicity test (FET), but assessment of sub-lethal toxic effects requires to develop more adapted tests. The present work aimed to add the recording of several sub-lethal endpoints in exposed zebrafish embryo-larval stages in order to increase the sensitivity of residual toxicity evaluation of WWTP effluents using a semi-quantitative method (iFET score). This approach was complemented with the genotoxicity assessment on the exposed embryos, a sub-acute hazard particularly relevant to evaluate a potential chronic toxicity risk of low and multi-contaminated environmental matrices. Additionally, endocrine activities of effluents were quantified using human reporter cell lines. This test battery was applied to the assessment of the residual toxicity of five biological treatment effluents, further treated or not using various ozonation treatments intended to improve pharmaceutical compounds removal. Acute toxicity towards zebrafish embryos was very low. However, iFET score approach proposed was able to reveal residual toxicity through the presence of developmental abnormalities in all samples tested. Additionally, a low residual genotoxicity was measured in embryos exposed to two of the WWTP effluents when all excepted one exhibited a residual

show abstract

Low dose exposure to Bisphenol A alters development of gonadotropin-releasing hormone 3 neurons and larval locomotor behavior in Japanese Medaka

Cited by 27 publications

References 68 publications

Motion behavior and metabolic response to microplastic leachates in the benthic foraminifera Haynesina germanica

Motion behavior and metabolic response to microplastic leachates in the benthic foraminifera Haynesina germanica

Influence of Endogenous and Exogenous Estrogenic Endocrine on Intestinal Microbiota in Zebrafish

Assessment of Ozone or Not-Treated Wastewater Ecotoxicity Using Mechanism-Based and Zebrafish Embryo Bioassays

Contact Info

Product

Resources

About