Mechanisms of tetraneedlelike ZnO whiskers reinforced forsterite/bioglass scaffolds

Shuai, Cijun; Deng, Junjie; Gao, Chengde; Feng, Pei; Peng, Shuping; Xiao, Tao; Deng, Youwen

doi:10.1016/j.jallcom.2015.02.077

Cited by 17 publications

(3 citation statements)

References 29 publications

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“…Meanwhile, heart as a vital organ has special electrophysiological behavior and the cardiac cells were in an electroactive condition. [17][18] It has been demonstrated that conductive polymers may promote the proliferation and differentiation of the electrical stimuli responsive cells, such as the stem cells, [19][20] myoblast cells, [21][22][23] nerve cells [24][25] and the cardiac cells. [26][27][28][29] Therefore, injectable hydrogels with conductivity as cardiac cell delivery vehicle are highly anticipated for cardiac repair.…”

Section: Introductionmentioning

confidence: 99%

“…Wang et al showed that using the chitosan based hydrogel as an injectable cell delivery vehicle could not only enhance the cell retention but also promote the cardiac differentiation of the brown adipose-derived stem cells. Meanwhile, the heart as a vital organ has special electrophysiological behavior and the cardiac cells were in an electroactive condition. , It has been demonstrated that conductive polymers may promote the proliferation and differentiation of the electrical stimuli responsive cells, such as stem cells, , myoblast cells, − nerve cells , and cardiac cells. − Therefore, injectable hydrogels with conductivity as cardiac cell delivery vehicle are highly anticipated for cardiac repair. Although conventional injectable conductive hydrogels showed a great deal of advantages such as the promotion of cell proliferation, they could not be long-term used with a stable function due to their nonself-healing property.…”

Section: Introductionmentioning

confidence: 99%

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Self-Healing Conductive Injectable Hydrogels with Antibacterial Activity as Cell Delivery Carrier for Cardiac Cell Therapy

Dong

Zhao

Guo

et al. 2016

ACS Appl. Mater. Interfaces

471

324

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Cell therapy is a promising strategy to regenerate cardiac tissue for myocardial infarction. Injectable hydrogels with conductivity and self-healing ability are highly desirable as cell delivery vehicles for cardiac regeneration. Here, we developed self-healable conductive injectable hydrogels based on chitosan-graft-aniline tetramer (CS-AT) and dibenzaldehyde-terminated poly(ethylene glycol) (PEG-DA) as cell delivery vehicles for myocardial infarction. Self-healed electroactive hydrogels were obtained after mixing CS-AT and PEG-DA solutions at physiological conditions. Rapid self-healing behavior was investigated by rheometer. Swelling behavior, morphology, mechanical strength, electrochemistry, conductivity, adhesiveness to host tissue and antibacterial property of the injectable hydrogels were fully studied. Conductivity of the hydrogels is ∼10(-3) S·cm(-1), which is quite close to native cardiac tissue. Proliferation of C2C12 myoblasts in the hydrogel showed its good biocompatibility. After injection, viability of C2C12 cells in the hydrogels showed no significant difference with that before injection. Two different cell types were successfully encapsulated in the hydrogels by self-healing effect. Cell delivery profile of C2C12 myoblasts and H9c2 cardiac cells showed a tunable release rate, and in vivo cell retention in the conductive hydrogels was also studied. Subcutaneous injection and in vivo degradation of the hydrogels demonstrated their injectability and biodegradability. Together, these self-healing conductive biodegradable injectable hydrogels are excellent candidates as cell delivery vehicle for cardiac repair.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Self-Healing Conductive Injectable Hydrogels with Antibacterial Activity as Cell Delivery Carrier for Cardiac Cell Therapy

Dong

Zhao

Guo

et al. 2016

ACS Appl. Mater. Interfaces

471

324

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“…The total weight of Zn in human body is about 1.4-2.3 g, with about 50% deposit in bones [16,17]. Tetrapod-like zinc oxide whisker (T-ZnO w ) is the only one of whiskers that has a spatial structure: Four needles of it stretch to different directions, offering an isotropic performance and helping to improve mechanical properties [18][19][20][21]. At the same time, T-ZnO w shows excellent antibacterial properties and good biocompatibility [22,23], which is beneficial to scaffolds used for implanting.…”

mentioning

confidence: 99%

Preparation and properties of T-ZnOw enhanced BCP scaffolds with double-layer structure by digital light processing

Pan

Hua

et al. 2022

J Adv Ceram

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Bone scaffolds require both good bioactivity and mechanical properties to keep shape and promote bone repair. In this work, T-ZnOw enhanced biphasic calcium phosphate (BCP) scaffolds with triply periodic minimal surface (TPMS)-based double-layer porous structure were fabricated by digital light processing (DLP) with high precision. Property of suspension was first discussed to obtain better printing quality. After sintering, T-ZnOw reacts with β-tricalcium phosphate (β-TCP) to form Ca19Zn2(PO4)14, and inhibits the phase transition to α-TCP. With the content of T-ZnOw increasing from 0 to 2 wt%, the flexural strength increases from 40.9 to 68.5 MPa because the four-needle whiskers can disperse stress, and have the effect of pulling out as well as fracture toughening. However, excessive whiskers will reduce the cure depth, and cause more printing defects, thus reducing the mechanical strength. Besides, T-ZnOw accelerates the deposition of apatite, and the sample with 2 wt% T-ZnOw shows the fastest mineralization rate. The good biocompatibility has been proved by cell proliferation test. Results confirmed that doping T-ZnOw can improve the mechanical strength of BCP scaffolds, and keep good biological property, which provides a new strategy for better bone repair.

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Novel Techniques of Scaffold Fabrication for Bioactive Glasses

Khurshid

Husain

Alotaibi

et al. 2019

Biomedical, Therapeutic and Clinical Applications of Bioactive Glasses

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Mechanisms of tetraneedlelike ZnO whiskers reinforced forsterite/bioglass scaffolds

Cited by 17 publications

References 29 publications

Self-Healing Conductive Injectable Hydrogels with Antibacterial Activity as Cell Delivery Carrier for Cardiac Cell Therapy

Self-Healing Conductive Injectable Hydrogels with Antibacterial Activity as Cell Delivery Carrier for Cardiac Cell Therapy

Preparation and properties of T-ZnOw enhanced BCP scaffolds with double-layer structure by digital light processing

Novel Techniques of Scaffold Fabrication for Bioactive Glasses

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