Mechanisms of spinal motoneurons survival in rats under simulated hypogravity on earth

Islamov, R. R.; Mishagina, E.A.; Tyapkina, O. V.; Shajmardanova, G.F.; Eremeev, A. M.; Kozlovskaya, I. B.; Nikolskij, E.E.; Grigorjev, A.I.

doi:10.1016/j.actaastro.2009.12.001

Cited by 16 publications

(6 citation statements)

References 15 publications

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“…To our knowledge there are only few trials examining spinal cord apoptosis following non traumatic disuse such as limb immobilization or hind limb unloading. Although Islamov et al (2011) did not report any sign of apoptosis within hind limb motoneurons during 35-day hind limb suspension, their results indicated the increased expression of antiapoptotic factors. It seems that this resistance of motoneurons to a decreased motor activity is not found in neonatal rats since we found an overexpression of caspase-3 in motoneurons within ventral horn.…”

Section: Discussionmentioning

confidence: 83%

Synaptophysin and caspase-3 expression on lumbar segments of spinal cord after sensorimotor restriction during early postnatal period and treadmill training

Stigger¹,

Barbosa

Marques

et al. 2018

J Exerc Rehabil

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The purpose of the current study was to investigate whether locomotor stimulation training could have beneficial effects on spinal cord plasticity consequent to sensorimotor restriction (SR). Male Wistar rats were exposed to SR from postnatal day 2 (P2) to P28. Control and experimental rats underwent locomotor stimulation training in a treadmill from P31 to P52. The intensity of the synaptophysin and caspase-3 immunoreaction was determined on ventral horn of spinal cord. The synaptophysin immunoreactivity was lower in the ventral horn of sensorimotor restricted rats compared to controls animals and was accompanied by an increased caspase-3 immunoreactivity. Those alterations were reversed at the end of the training period. Our results suggest that immobility affects the normal developmental process that spinal cord undergoes in early postnatal life influencing both pro-apoptotic and synapse markers. Also, we demonstrated that this phenomenon was reversed by 3 weeks of treadmill training.

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Section: Discussionmentioning

confidence: 83%

Synaptophysin and caspase-3 expression on lumbar segments of spinal cord after sensorimotor restriction during early postnatal period and treadmill training

Stigger¹,

Barbosa

Marques

et al. 2018

J Exerc Rehabil

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“…However, whether nervous tissues participate in the development of HMS is still unclear. Apoptosis was not found in rat motoneurons exposed to hypogravity modeled on Earth [1]. At the same time, a significant increase in the expression of heat shock proteins HSP25 and, to a less extent, HSP70 was found.…”

mentioning

confidence: 77%

Astrocytes and microglia of the mouse spinal cord during hind limb suspension

et al. 2014

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“…Earlier, using the mice HUM, we hypothesized that HMS pathogenesis partly may be due to spinal motoneurons disorders (Islamov et al, 2011; Chelyshev et al, 2014). Taking into consideration our HUM findings demonstrating decreases in the gray and white matter areas, decrease in ChAT immunoexpression, changes in myelin gene expression, and phenotypic modifications of glial cells in lumbar spinal cords, the results of this investigation suggest that motoneurons contribute to the HMS development.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatic Study of Transcriptome Changes in the Mice Lumbar Spinal Cord After the 30-Day Spaceflight and Subsequent 7-Day Readaptation on Earth: New Insights Into Molecular Mechanisms of the Hypogravity Motor Syndrome

et al. 2019

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The hypogravity motor syndrome (HMS) is one of the deleterious impacts of weightlessness on the human body in orbital space missions. There is a hypothesis that disorders of musculoskeletal system as part of HMS arise in consequence of changes in spinal motor neurons. The study was aimed at bioinformatic analysis of transcriptome changes in lumbar spinal cords of mice after a 30-day spaceflight aboard biosatellite Bion-M1 (space group, S) and subsequent 7-day readaptation to the Earth’s gravity (recovery group, R) when compared with control mice (C group) housed in simulated biosatellite conditions on the Earth. Gene ontology and human phenotype ontology databases were used to detect biological processes, molecular functions, cellular components, and human phenotypes associated with HMS. Our results suggest resemblance of molecular changes developing in space orbit and during the postflight recovery to terrestrial neuromuscular disorders. Remarkably, more prominent transcriptome changes were revealed in R vs. S and R vs. C comparisons that are possibly related to the 7-day recovery period in the Earth’s gravity condition. These data may assist with establishment of HMS pathogenesis and proposing effective preventive and therapeutic options.

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Mechanisms of spinal motoneurons survival in rats under simulated hypogravity on earth

Cited by 16 publications

References 15 publications

Synaptophysin and caspase-3 expression on lumbar segments of spinal cord after sensorimotor restriction during early postnatal period and treadmill training

Synaptophysin and caspase-3 expression on lumbar segments of spinal cord after sensorimotor restriction during early postnatal period and treadmill training

Astrocytes and microglia of the mouse spinal cord during hind limb suspension

Bioinformatic Study of Transcriptome Changes in the Mice Lumbar Spinal Cord After the 30-Day Spaceflight and Subsequent 7-Day Readaptation on Earth: New Insights Into Molecular Mechanisms of the Hypogravity Motor Syndrome

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