Mechanisms of pollutant-induced toxicity in skin and detoxification: Anti-pollution strategies and perspectives for cosmetic products

Richard, Fanny; Creusot, T.; Catoire, Sophie; Egles, Christophe; Ficheux, H.

doi:10.1016/j.pharma.2019.07.001

Cited by 13 publications

(7 citation statements)

References 97 publications

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“…However, the depletion of skin defensive system can lead to premature skin aging [ 55 ]. To counteract oxidative damage, topical antioxidant formulations have been developed to protect skin [ 130 ]. Moreover, a healthy diet, including vitamins and micronutrients helps restore the gut microbiome, and provides further protection to preserve the skin health [ 131 ].…”

Section: Environmental Protection Strategiesmentioning

confidence: 99%

Ultraviolet Light Protection: Is It Really Enough?

Farris

Valacchi

2022

Antioxidants

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Our current understanding of the pathogenesis of skin aging includes the role of ultraviolet light, visible light, infrared, pollution, cigarette smoke and other environmental exposures. The mechanism of action common to these exposures is the disruption of the cellular redox balance by the directly or indirectly increased formation of reactive oxygen species that overwhelm the intrinsic antioxidant defense system, resulting in an oxidative stress condition. Altered redox homeostasis triggers downstream pathways that contribute to tissue oxinflammation (cross-talk between inflammation and altered redox status) and accelerate skin aging. In addition, both ultraviolet light and pollution increase intracellular free iron that catalyzes reactive oxygen species generation via the Fenton reaction. This disruption of iron homeostasis within the cell further promotes oxidative stress and contributes to extrinsic skin aging. More recent studies have demonstrated that iron chelators can be used topically and can enhance the benefits of topically applied antioxidants. Thus, an updated, more comprehensive approach to environmental or atmospheric aging protection should include sun protective measures, broad spectrum sunscreens, antioxidants, chelating agents, and DNA repair enzymes.

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Section: Environmental Protection Strategiesmentioning

confidence: 99%

Ultraviolet Light Protection: Is It Really Enough?

Farris

Valacchi

2022

Antioxidants

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“…The link between environmental factors such as O 3 and pollution negatively impacts skin cells by upregulating xenobiotic metabolism and a subsequent activation of oxidative stress and inflammation mechanisms [36]. The consequences of our findings for allergic patients with type I allergies are that the induction of symptoms by exposure to the respective allergens has an impact to the entire organism including barrier-related functions.…”

Section: Discussionmentioning

confidence: 85%

Skin Physiology, Mucosal Functions, and Symptoms Are Modulated by Grass Pollen and Ozone Double Exposure in Allergic Patients

Fluhr

Stevanovic

Joshi

et al. 2023

Skin Pharmacol Physiol

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Introduction: Along with climate changes, we see an increase in allergic symptoms and the number of pollen-allergic patients in many countries. Increased allergic symptoms are associated with an elevated ozone exposure which may be linked by impaired epithelial barrier function. This study aimed to quantify the clinical effect of ozone and pollen double exposure (DE). We tested whether ozone impairs barrier-related skin physiology and mucosal functions under double exposure with pollen ozone in grass pollen-allergic patients versus healthy controls. Methods: This case-control study included 8 grass pollen-allergic patients and 8 non-allergic healthy subjects exposed to grass pollen and ozone in the GA²LEN pollen chamber, comparing shorter and longer DE duration. Non-invasive skin physiological parameters were assessed, including stratum corneum hydration, skin redness, surface pH, and basal transepidermal water loss (TEWL) as a parameter for epidermal barrier function. The subjects’ general well-being, bronchial, nasal, and ocular symptoms were documented. Results: Skin physiology tests revealed that DE in allergic patients deteriorates the epidermal barrier function, increases the surface pH and skin redness. DE significantly induced nasal secretion in pollen-allergic versus healthy subjects, which was more pronounced with longer DE. The general well-being was significantly impaired under DE versus pollen or ozone alone, with a negative influence of DE-duration. No relevant bronchial symptoms were recorded. Conclusion: Skin physiology and nasal mucosal symptoms and are negatively affected by ozone and grass pollen DE in allergic patients. The negative effects showed, in some parameters, a dose(time)-response relationship. The surface pH can be regarded as a possible modulatory mechanism.

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“…Exposure to numerous environmental pro-oxidants such as pollutants, radiation, chemicals, drugs, and cosmetic products causes oxidative stress in human beings, specifically at the cellular level in various organs including the skin and liver [33]. These pro-oxidant agents are harmful because they interact with bio-membrane proteins and lipids, which induces lipid peroxidation and interacts with DNA to induce genotoxicity in cells [25].…”

Section: Discussionmentioning

confidence: 99%

Tamarix articulata extract offers protection against toxicity induced by beauty products in Hs27 human skin fibroblasts

Alnuqaydan,

Zainy,

Almutary

et al. 2023

PLoS ONE

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The current study evaluates the cytotoxicity, mode of cell death and chemical analysis of selected beauty products and evaluation of the protective effect of Tamarix articulata (TA) extract against toxicity induced by beauty products in skin fibroblasts (Hs27). MTT and Crystal violet (CV) assays were used to determine the dose-dependent cytotoxic effects of beauty products against Hs27 fibroblasts. DNA fragmentation assay and annexin-V staining were conducted to determine the mode of cell killing induced by evaluated beauty products. Quantification of reactive oxygen species (ROS) and antioxidant enzyme levels were used to evaluate the oxidative stress. Chemical analysis and heavy metals were evaluated to determine beauty products. Pre-treatment with TA extract for different time points followed by time-dependent exposure with beauty products to assess the protective effect of TA extract in Hs27 cells was analyzed by MTT and CV assays. Owing to the presence of various harmful heavy metals such as arsenic (As), chromium (Cr), cadmium (Cd), nickel (Ni), and lead (Pb) in beauty products, our results revealed that all beauty products induce significant cytotoxicity over time (1, 4 h) in a dose-dependent (125, 250, 500 μg/mL) manner. DNA fragmentation assay, quantification of apoptosis by annexin-V staining, determination of ROS and antioxidant enzymes (CAT, GSH-Px and SOD) revealed that the induced cytotoxicity was caused by oxidative stress-mediated apoptosis. However, pre-incubation with a safe dose (50 μg/mL) of TA for different times (24, 48 h) followed by exposure to various doses (62.5, 125, 250, 500 μg/mL) of beauty products for different times (1, 4 h) revealed significant (*p≤0.05, **p≤0.01) protection against beauty product-mediated cytotoxicity. The effect was more pronounced for 1 h exposure to beauty products compared to 4 h. Our study demonstrates that the due to the presence of heavy metals in synthetic beauty products exhibit marked toxicity to skin fibroblasts due to oxidative stress-mediated apoptosis. However, the presence of abundant bioactive polyphenols with promising antiscavenging activity in TA extracts significantly nullifies cytotoxicity promoted by examined beauty products in skin fibroblasts (Hs27).

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Mechanisms of pollutant-induced toxicity in skin and detoxification: Anti-pollution strategies and perspectives for cosmetic products

Cited by 13 publications

References 97 publications

Ultraviolet Light Protection: Is It Really Enough?

Ultraviolet Light Protection: Is It Really Enough?

Skin Physiology, Mucosal Functions, and Symptoms Are Modulated by Grass Pollen and Ozone Double Exposure in Allergic Patients

Tamarix articulata extract offers protection against toxicity induced by beauty products in Hs27 human skin fibroblasts

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