Mechanisms of nisin resistance in Gram-positive bacteria

Zhou, Hui; Fang, Jun; Tian, Yun; Lü, Xiang

doi:10.1007/s13213-013-0679-9

Cited by 127 publications

(94 citation statements)

References 75 publications

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“…The mechanisms of nisin resistance are complicated and may differ among strains. Therefore, the consumption of food contaminated by nisin-resistant variants of pathogens increases the risk of contracting diseases (Zhou et al, 2014). Synergism is a positive interaction created when two compounds combined and exert an inhibitory effect that is greater than the sum of their individual effects (Kumar, Lankalapalli, & Kumar, 2014).…”

Section: Determination Of Alone and Synergistic Effectsmentioning

confidence: 99%

“…(Periago & Moezelaar, 2001;Severina, Severin, & Tomasz, 1998). Nevertheless, the antibacterial efficacy of nisin in food preservation has been compromised by the occurrence of nisin resistance in various bacteria because of extensive use (Zhou, Fang, Tian, & Lu, 2014). Until now, the resistance to nisin has been reported in several species of bacteria, including S. aureus (Blake, Randall, & Neill, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Synergistic interactions of nisin in combination with cinnamaldehyde against Staphylococcus aureus in pasteurized milk

et al. 2017

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Section: Determination Of Alone and Synergistic Effectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synergistic interactions of nisin in combination with cinnamaldehyde against Staphylococcus aureus in pasteurized milk

et al. 2017

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“…Its small molecular size allows the production of films that release the peptide once it is in contact with a liquid or solid food . Studies have shown that nisin has a dual mode of action, by inhibiting cell wall synthesis and formation membrane pores causing a rapid cell death . Consequently, nisin can induce cell autolysis and inhibit the outgrowth of bacterial spores .…”

Section: Introductionmentioning

confidence: 99%

Influence of melt processing on biodegradable nisin‐PBAT films intended for active food packaging applications

Zehetmeyer

Meira

Scheibel

et al. 2015

J of Applied Polymer Sci

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Biodegradable poly(butylene adipate-co-terephthalate) (PBAT) films incorporated with different levels of the antimicrobial peptide nisin were developed by melt processing. Structural, morphological, thermal, mechanical, and antimicrobial properties of the films were determined. The X-ray diffraction patterns exhibited decreasing levels of intensity at 2h values as the concentration of nisin increased. Scanning electron microscopy showed a heterogeneous morphology when higher amounts of nisin were incorporated. The antimicrobial films tested presented no significant differences in the melting temperature (123-1258C), and the crystallization temperature ranged from 69 to 758C. The addition of nisin caused no significant modification in tensile strength values. However, results of Young's modulus and deformation at break differed significantly among samples. Active films demonstrated inhibition against the Gram-positive bacterium Listeria monocytogenes. These results demonstrated that PBAT/nisin films produced by melt processing present a great potential for use as active food packaging materials aiming enhanced food safety. V C 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43212.

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“…Some LPS modifications were shown to contribute to bacterial resistance to AMPs. The modifications of the LPS depend on bacterial species and environmental conditions, and it was shown that not all modifications are found in all bacteria species [71]. Here we will discuss some of the changes in the outer surface with respect to AMP resistance and susceptibility.…”

Section: Surface Modifications Of Gram-negative Bacteriamentioning

confidence: 97%

“…An in-vitro nisin binding assay demonstrated that nisin binds better to a lipid-monolayer derived from the WT than the resistant strain [70]. Other studies reported that nisin resistant L. monocytogenes strains had a greater proportion of saturated fatty acids whereas the WT had more unsaturated ones [71]. In…”

Section: Changing the Fatty Acids Compositionmentioning

confidence: 99%

Defensive remodeling: How bacterial surface properties and biofilm formation promote resistance to antimicrobial peptides

Nuri

Shprung

Shai

2015

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Multidrug resistance bacteria are a major concern worldwide. These pathogens cannot be treated with conventional antibiotics and thus alternative therapeutic agents are needed. Antimicrobial peptides (AMPs) are considered to be good candidates for this purpose. Most AMPs are short and positively charged amphipathic peptides, which are found in all known forms of life. AMPs are known to kill bacteria by binding to the negatively charged bacterial surface, and in most cases cause membrane disruption. Resistance toward AMPs can be developed, by modification of bacterial surface molecules, secretion of protective material and up-regulation or elimination of specific proteins. Because of the general mechanisms of attachment and action of AMPs, bacterial resistance to AMPs often involves biophysical and biochemical changes such as surface rigidity, cell wall thickness, surface charge, as well as membrane and cell wall modification. Here we focus on the biophysical, surface and surrounding changes that bacteria undergo in acquiring resistance to AMPs. In addition we discuss the question of whether bacterial resistance to administered AMPs might compromise our innate immunity to endogenous AMPs. This article is part of a Special Issue entitled: Bacterial Resistance to Antimicrobial Peptides.

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Mechanisms of nisin resistance in Gram-positive bacteria

Cited by 127 publications

References 75 publications

Synergistic interactions of nisin in combination with cinnamaldehyde against Staphylococcus aureus in pasteurized milk

Synergistic interactions of nisin in combination with cinnamaldehyde against Staphylococcus aureus in pasteurized milk

Influence of melt processing on biodegradable nisin‐PBAT films intended for active food packaging applications

Defensive remodeling: How bacterial surface properties and biofilm formation promote resistance to antimicrobial peptides

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