Mechanisms of Lung Damage and Development of COPD Due to Household Biomass-Smoke Exposure: Inflammation, Oxidative Stress, MicroRNAs, and Gene Polymorphisms

Ortiz‐Quintero, Blanca; Martinez-Espinosa, Israel; Pérez‐Padilla, Rogelio

doi:10.3390/cells12010067

Cited by 32 publications

(25 citation statements)

References 195 publications

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“…Our results contrast to a previous study, in which higher levels of IL-6, CXCL8 and TNF were found in lower airways of rural Indian women who were chronically exposed to smoke from biomass compared to liquified petroleum gas during cooking [ 5 ]. Also, several proinflammatory cytokines in serum samples have been associated with biomass smoke [ 25 ]. To estimate the impact of solid fuel use on upper airway inflammation, factors listed above need to be considered in future studies, but also including contributing inflammatory activity due to NP pathogens and exposure to solid fuel use in the neighborhood [ 26 ] and at work [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Household air pollution and pneumococcal density related to nasopharyngeal inflammation in mothers and children in Ethiopia: A cross-sectional study

Olsson,

Tamire,

Samuelsson

et al. 2024

PLoS ONE

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Background Three billion people in low- and middle-income countries are exposed to household air pollution as they use biomass fuel for cooking. We investigated the associations between solid fuel use and nasopharyngeal (NP) inflammation, as well as the associations between high pneumococcal density and NP inflammation, in mothers and children in rural and urban Ethiopia. Materials and methods Sixty pairs of mothers (median age, 30 years; range, 19–45 years) with a child (median age, 9 months; range, 1–24 months) were included from rural Butajira (n = 30) and urban Addis Ababa (n = 30) in Ethiopia. The cohort was randomly selected from a previous study of 545 mother/child pairs included 2016. Questionnaire-based data were collected which included fuel type used (solid: wood, charcoal, dung or crop waste; cleaner: electricity, liquefied petroleum gas). Nasopharyngeal (NP) samples were collected from all mothers and children and analyzed for the levels of 18 cytokines using a Luminex immunoassay. Pneumococcal DNA densities were measured by a real-time multiplex PCR and a high pneumococcal density was defined as a cyclic threshold (Ct) value ≤ 30. Results Mothers from rural areas had higher median CXCL8 levels in NP secretions than those from urban areas (8000 versus 1900 pg/mL; p < 0.01), while rural children had slightly higher IL-10 levels than those from the urban area (26 vs 13 pg/mL; p = 0.04). No associations between fuel type and cytokine levels were found. However, a high pneumococcal density was associated with higher levels of cytokines in both mothers (CCL4, CXCL8, IL-1β, IL-6 and VEGF-A) and children (CCL4, CXCL8, IL-1β, IL-6 and IL-18). Conclusions No significant associations were found between solid fuel use and NP inflammation in Ethiopian mothers and children, but the inflammatory activity was higher in individuals living in the rural compared to the urban area. In addition, high cytokine levels were associated with high pneumococcal density in both mothers and children, indicating a significant impact of NP pathogens on inflammatory mediator levels in upper airways.

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Section: Discussionmentioning

confidence: 99%

Household air pollution and pneumococcal density related to nasopharyngeal inflammation in mothers and children in Ethiopia: A cross-sectional study

Olsson,

Tamire,

Samuelsson

et al. 2024

PLoS ONE

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“…Cigarette smoke is a well known cause of COPD [31] provoking endothelial apoptosis and dysfunction [32,33]. Biomass stove smoke particularly affects women from low-income and middleincome countries [30], who may develop more severe PH [34] compared with those exposed to tobacco. Several ILDs are either strongly associated with or at increased risk from tobacco exposure [35], but its relevance to PH development is unknown, although similar effects on the endothelium may be hypothesized.…”

Section: Environmental Exposuresmentioning

confidence: 99%

“…The most studied environmental pollutants in COPD and ILD are tobacco (and in COPD, biomass smoke from household stoves [30]), airborne particulates such as nitric dioxide (NO 2 ), ozone (O 3 ), carbon monoxide (CO) and particulate matter less than 10 μm (PM 10 ) or less than 2.5 μm (PM 2.5 ). However, few studies have focused on these agents and the development of PH.…”

Section: Environmental Exposuresmentioning

confidence: 99%

Pulmonary hypertension in interstitial lung disease and in chronic obstructive pulmonary disease: different entities?

Piccari

Aguilar-Colindres

Rodríguez-Chiaradia

2023

Current Opinion in Pulmonary Medicine

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Purpose of review Pulmonary hypertension (PH) is a common complication of both chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD), classified as Group 3 PH. To which extent PH presents and behaves similarly in COPD and ILD is unclear. This review examines the similarities and differences in pathogenesis, clinical presentation, natural history and treatment response of PH in COPD and ILD. Recent findings The latest studies on PH in chronic lung disease have re-evaluated the role of traditionally held etiopathogenetic factors such as tobacco exposure and hypoxia, although new ones such as airborne pollutant and genetic mutations are increasingly recognized. We examine common and diverging factors involved in PH development in COPD and ILD, as well as common and diverging clinical features of presentation, natural history and response to treatment and highlight areas for future research. Summary The development of PH in lung disease significantly worsens the morbidity and mortality of patients with COPD and ILD. However, recent findings show importance of recognizing distinct patterns and behaviors of pulmonary vascular disease, taking into account the specific underlying lung disease and severity of the hemodynamic involvement. Further studies are needed to build evidence on these aspects, especially in early disease.

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“…ХОБЛ представляет собой сложное гетерогенное заболевание, характеризующееся воспалительной реакцией на хроническое воздействие вдыхаемых токсичных частиц, вызываю щих повреждение легочной ткани 2 . Для ХОБЛ характерны разрушение паренхимы, эмфизема, гиперсекреция Хронические заболевания легких слизи, сужение просвета дыхательных путей, очаговый фиброз [36].…”

Section: роль микрорнк в патогенезе и диагностике хронической обструк...unclassified

The role of microRNA in the pathogenesis of bronchoobstructive diseases

et al. 2023

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The review analyzes the role of microRNAs in the pathogenesis of bronchopulmonary diseases. The universality of the mechanisms underlying epigenetics causes a continuously growing interest in research in this field in various fields of medicine. Research in the field of epigenetics not only allows us to expand knowledge in the field of etiology and pathogenesis, but also helps to explain the heterogeneity of the disease. Currently, biomarkers used in determining the phenotype of bronchial asthma or COPD are not able to display the variety of pathological processes involved in the pathogenesis of the disease at the molecular level. It is noteworthy that microRNAs retain their stability in various body environments, are resistant to high temperatures, pH fluctuations, and freeze-thaw cycles, which greatly simplifies the process of detecting these molecules in biological fluids. The amount of detected microRNA is highly specific for a particular pathological process occurring intracellularly. Currently, biomarkers used in determining the phenotype of bronchial asthma or chronic obstructive pulmonary disease are not able to reflect the variety of pathological processes involved in the pathogenesis of the disease at the molecular level. For both diseases, the key links are known to be inflammation, airway remodeling, and an abnormal response of epithelial cells to external stimuli. Thus, there is a great potential for using microRNAs in clinical practice: as noninvasive biomarkers reflecting key points of pathogenesis, as a prognostic biomarker predicting response to therapy, and possibly in the future as new therapeutic targets.

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Mechanisms of Lung Damage and Development of COPD Due to Household Biomass-Smoke Exposure: Inflammation, Oxidative Stress, MicroRNAs, and Gene Polymorphisms

Cited by 32 publications

References 195 publications

Household air pollution and pneumococcal density related to nasopharyngeal inflammation in mothers and children in Ethiopia: A cross-sectional study

Household air pollution and pneumococcal density related to nasopharyngeal inflammation in mothers and children in Ethiopia: A cross-sectional study

Pulmonary hypertension in interstitial lung disease and in chronic obstructive pulmonary disease: different entities?

The role of microRNA in the pathogenesis of bronchoobstructive diseases

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