Mechanisms of interference of p-diphenols with the Trinder reaction

Tarasek, Damian; Gąsowska-Bajger, Beata; Wojtasek, Hubert

doi:10.1016/j.bioorg.2020.103692

Cited by 15 publications

(2 citation statements)

References 46 publications

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“…Next, we evaluated the catalytic kinetics of glucose oxidase based on Trinder reaction. [ 44 ] Glucose oxidase first catalyzed glucose into hydrogen peroxide, which subsequently was catalyzed by peroxidase. The produced substance can induce chromogenic substances 4‐aminoantipyrine to form quinone imines.…”

Section: Resultsmentioning

confidence: 99%

Fluorescence‐Amplified Origami Microneedle Device for Quantitatively Monitoring Blood Glucose

Wang

et al. 2023

Advanced Materials

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Exploration of clinically acceptable blood glucose monitors has been engaging in the past decades, yet the ability to quantitatively detect blood glucose in a painless, accurate, and highly sensitive manner remains limited. Herein, a fluorescence-amplified origami microneedle (FAOM) device is described that integrates tubular DNA-origami nanostructures and glucose oxidase molecules into its inner network to quantitatively monitor blood glucose. The skin-attached FAOM device can collect glucose molecules in situ and transfer the input into a proton signal after the oxidase's catalysis. The proton-driven mechanical reconfiguration of DNA-origami tubes separates fluorescent molecules and their quenchers, eventually amplifying the glucose-correlated fluorescence signal. The function equation established on clinical examinees suggests that FAOM can report blood glucose in a highly sensitive and quantitative manner. In clinical blind tests, the FAOM achieves well-matched accuracy (98.70 ± 4.77%) compared with a commercial blood biochemical analyzer, fully meeting the requirements of accurate blood glucose monitoring. The FAOM device can be inserted into skin tissue in a trivially painful manner and with minimal leakage of DNA origami, substantially improving the tolerance and compliance of the blood glucose test.

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Section: Resultsmentioning

confidence: 99%

Fluorescence‐Amplified Origami Microneedle Device for Quantitatively Monitoring Blood Glucose

Wang

et al. 2023

Advanced Materials

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“…Our new practice greatly improved the reliability of renal function evaluation in our hospitals and the safety of diagnostic procedures and eGFR-based drug dosage as well. Although the nature of these drug-related interferences is not fully clear ( 26 ), our hypothesis is that drugs and/or drug-related substances with reducing chemical properties may interfere with the hydrogen peroxide/peroxidase step, thus severely affecting the reporter reaction.…”

Section: Discussionmentioning

confidence: 99%

Emergency medicine pharmacotherapy compromises accuracy of plasma creatinine determination by enzyme-based methods: real-world clinical evidence and implications for clinical practice

Demlova,

Kozakova,

Rihacek

et al. 2024

Front. Med.

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BackgroundAssessment of kidney function in emergency settings is essential across all medical subspecialties. Daily assessment of patient creatinine results from emergency medical services showed that some deviated from expected values, implying drug-related interference.MethodsReal-time clinical evaluation of an enzyme method (Roche CREP2) in comparison with the Jaffé gen. 2 method (Roche CREJ2) was performed. During the period of December 2022 and January 2023, we analyzed 8,498 patient samples, where 5,524 were heavily medicated STAT patient specimens, 500 were pediatric specimens, and 2,474 were from a distant general population in a different region using the same methods.ResultsIn 109 out of 5,524 hospital specimens (1.97%, p < 0.001), the CREP2 value was apparently (25% or more) lower than CREJ2. Suspect interfering medication was found in a sample of 43 out of 46 reviewed patients where medication data were available. This phenomenon was not observed in the general population.ConclusionIn a polymedicated urgent care hospital population, a creatinine enzyme method produces unreliable results, apparently due to multiple drug-related interferences.

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Design and Development of an Economical Point-of-Care Capillary Blood Hemoglobin Quantification ‘Internet of Things’ Enabled Device for Long-Term Hemoglobin Level Monitoring

Srivastava

Ghosh²,

Bodakhe³

2022

Trans Indian Natl. Acad. Eng.

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Mechanisms of interference of p-diphenols with the Trinder reaction

Cited by 15 publications

References 46 publications

Fluorescence‐Amplified Origami Microneedle Device for Quantitatively Monitoring Blood Glucose

Fluorescence‐Amplified Origami Microneedle Device for Quantitatively Monitoring Blood Glucose

Emergency medicine pharmacotherapy compromises accuracy of plasma creatinine determination by enzyme-based methods: real-world clinical evidence and implications for clinical practice

Design and Development of an Economical Point-of-Care Capillary Blood Hemoglobin Quantification ‘Internet of Things’ Enabled Device for Long-Term Hemoglobin Level Monitoring

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