Mechanisms of insulin-dependent glucose transport into porcine and bovine skeletal muscle

Dühlmeier, R.; Hacker, Anja; Widdel, Andrea; Engelhardt, W; Sallmann, H.‐P.

doi:10.1152/ajpregu.00502.2004

Cited by 26 publications

(31 citation statements)

References 61 publications

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“…Indeed, setting e = 0 or e > 0 small might not affect the remaining parameter point estimates to any substantial degree. Since a small value of insulin-independent glucose tissue uptake cannot be excluded physiologically according to [8] and [22], we add it to the model in order to exploit the mathematical advantage, which it offers, in satisfying the conditions of both corollaries. It can be seen that for larger e , the estimation of the upper bound M G of G in Lemma 2 could be smaller, which would help in checking the conditions of the corollaries.…”

Section: Discussionmentioning

confidence: 99%

“…Decreased insulin-dependent glucose transport by GLUT4 also occurs, for example, in chronic alcohol users ([22]). Low insulin sensitivity may also occur in type 1 diabetes and could be caused by impaired GLUT4 translocation ([8]). This indicates that insulin-independent GLUT1 may be dominant in translocation of glucose molecules ([8]) at least in some disease states.…”

Section: Single Delay Models For Intravenous Glucose Tolerance Testmentioning

confidence: 99%

“…Low insulin sensitivity may also occur in type 1 diabetes and could be caused by impaired GLUT4 translocation ([8]). This indicates that insulin-independent GLUT1 may be dominant in translocation of glucose molecules ([8]) at least in some disease states. These considerations, as well as potential concentration effects shifting (at least in the short term) glucose to the interstitial space, prompt a cautious re-evaluation of the role of insulin-independent tissue glucose uptake and therefore of the generally positive, if small, value of the parameter e .…”

Section: Single Delay Models For Intravenous Glucose Tolerance Testmentioning

confidence: 99%

“…In [18] and [20], the insulin-independent glucose elimination rate parameter e is set to zero. However, from a physiological point of view, insulin-independent glucose elimination rate could be greater than zero ([8], [22]), so that this term should not simply be ignored. More discussions can be found in [19].…”

Section: Numerical Simulationsmentioning

confidence: 99%

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The range of time delay and the global stability of the equilibrium for an IVGTT model

Wang

Gaetano³

et al. 2012

Mathematical Biosciences

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Diabetes mellitus has become a prevalent disease in the world. Diagnostic protocol for the onset of diabetes mellitus is the initial step in the treatments. The intravenous glucose tolerance test (IVGTT) has been considered as the most accurate method to determine the insulin sensitivity and glucose effectiveness. It is well known that there exists a time delay in insulin secretion stimulated by the elevated glucose concentration level. However, the range of the length of the delay in the existing IVGTT models are not fully discussed and thus in many cases the time delay may be assigned to a value out of its reasonable range. In addition, several attempts had been made to determine when the unique equilibrium point is globally asymptotically stable. However, all these conditions are delay-independent. In this paper, we discuss the range of the time delay and provide easy-to-check delay-dependent conditions for the global asymptotic stability of the equilibrium point for a recent IVGTT model through Liapunov function approach. Estimates of the upper bound of the delay for global stability are given in corollaries. In addition, the numerical simulation in this paper is fully incorporated with functional initial conditions, which is natural and more appropriate in delay differential equation system.

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Section: Discussionmentioning

confidence: 99%

Section: Single Delay Models For Intravenous Glucose Tolerance Testmentioning

confidence: 99%

Section: Single Delay Models For Intravenous Glucose Tolerance Testmentioning

confidence: 99%

Section: Numerical Simulationsmentioning

confidence: 99%

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The range of time delay and the global stability of the equilibrium for an IVGTT model

Wang

Gaetano³

et al. 2012

Mathematical Biosciences

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“…Under insulin stimulation, GLUT4 undergoes a rapid translocation from the intracellular location to the cell surface, resulting in a dramatic increase in cellular glucose transport activity [47]. In bovine muscle, the insulin-induced GLUT4 translocation to the plasma membrane is significantly lower than in porcine, which may explain the lower insulin sensitivity in adult ruminants compared with monogastric omnivores [48]. It has been speculated that the replacement of Asn 508 in the Cterminus of human and rodent GLUT4 by His 508 in bovine GLUT4 may contribute to the impaired insulin stimulation of translocation [49].…”

Section: Glut4 (Slc2a4)mentioning

confidence: 99%

Functional Properties and Genomics of Glucose Transporters

Zhao

Keating²

2007

481

393

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Glucose is the major energy source for mammalian cells as well as an important substrate for protein and lipid synthesis. Mammalian cells take up glucose from extracellular fluid into the cell through two families of structurallyrelated glucose transporters. The facilitative glucose transporter family (solute carriers SLC2A, protein symbol GLUT) mediates a bidirectional and energy-independent process of glucose transport in most tissues and cells, while the Na + /glucose cotransporter family (solute carriers SLC5A, protein symbol SGLT) mediates an active, Na + -linked transport process against an electrochemical gradient. The GLUT family consists of thirteen members (GLUT1-12 and HMIT). Phylogenetically, the members of the GLUT family are split into three classes based on protein similarities. Up to now, at least six members of the SGLT family have been cloned (SGLT1-6). In this review, we report both the genomic structure and function of each transporter as well as intra-species comparative genomic analysis of some of these transporters. The affinity for glucose and transport kinetics of each transporter differs and ranges from 0.2 to 17mM. The ability of each protein to transport alternative substrates also differs and includes substrates such as fructose and galactose. In addition, the tissue distribution pattern varies between species. There are different regulation mechanisms of these transporters. Characterization of transcriptional control of some of the gene promoters has been investigated and alternative promoter usage to generate different protein isoforms has been demonstrated. We also introduce some pathophysiological roles of these transporters in human.

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Insulin Resistance in Dairy Cows

Koster

Opsomer

2013

Veterinary Clinics of North America: Food Animal Practice

290

268

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Mechanisms of insulin-dependent glucose transport into porcine and bovine skeletal muscle

Abstract: Duhlmeier, Reinhard, Anja Hacker, Andrea Widdel, Wolfgang von Engelhardt, and Hans-Peter Sallmann. Mechanisms of insulindependent glucose transport into porcine and bovine skeletal muscle.

Cited by 26 publications

References 61 publications

The range of time delay and the global stability of the equilibrium for an IVGTT model

The range of time delay and the global stability of the equilibrium for an IVGTT model

Functional Properties and Genomics of Glucose Transporters

Insulin Resistance in Dairy Cows

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