1993
DOI: 10.1016/0264-410x(93)90218-m
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Mechanisms of immune failure in burn injury

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Cited by 30 publications
(22 citation statements)
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“…Endotoxin is considered to be an important factor in the pathology of sepsis (a major complication after thermal injury). However, previous studies have shown that multiple organ failure and significant mortality in the absence of endotoxemia does occur [36,37].…”
Section: Discussionmentioning
confidence: 96%
“…Endotoxin is considered to be an important factor in the pathology of sepsis (a major complication after thermal injury). However, previous studies have shown that multiple organ failure and significant mortality in the absence of endotoxemia does occur [36,37].…”
Section: Discussionmentioning
confidence: 96%
“…The production of these factors after burn is associated with decreased lymphocyte functions including proliferation, IL-2 production and IL-2R expression (Miller-Graziano et al 1991, 1993, Fukushima et al 1994, Horgan et al 1994a, Meert et al 1996, Gregory et al 2000c. Furthermore, exposure of macrophages to testosterone can increase production of TGF-directly (Benten et al 1999), and thus that of IL-6 and PGE 2 (MillerGraziano et al 1991, 1993, Olsen et al 1994. Therefore, an increase in the percentage of macrophages after injury would result in an exaggerated effect of these factors on lymphocyte function, which could be ameliorated by the administration of flutamide.…”
Section: Discussionmentioning
confidence: 99%
“…However, as the IL-2R expression was fully recovered, but proliferation and IL-2 production were only partially restored, it is unlikely that this change in IL-2R expression is relevant. In addition, in experiments demonstrating reduced IL-2R after injury, lymphocyte proliferation could be restored by the addition of exogenous IL-2 (Teodorczyk-Injeyan et al 1986, Sparkes 1993, Horgan et al 1994b. Thus it appears that the lack of IL-2, not IL-2R, is the critical defect in lymphocyte function after burn.…”
Section: Discussionmentioning
confidence: 99%
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