1998
DOI: 10.1002/jlb.63.1.51
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Thermal injury-induced immunosuppression in mice: the role of macrophage-derived reactive nitrogen intermediates

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Cited by 74 publications
(96 citation statements)
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“…Work by our laboratory and others has previously identified a suppressive role for the APC (i.e., macrophages and/or dendritic cells) after burn injury in experimental mouse models (2,21,36,37) and humans (10). In our studies, we did not distinguish whether the APCs responsible for injury-induced immune suppression were monocytes/macrophages vs dendritic cells, because we used a mixture of anti-F4/80 and anti-CD11c mAbs to isolate the cells.…”
Section: Discussionmentioning
confidence: 94%
“…Work by our laboratory and others has previously identified a suppressive role for the APC (i.e., macrophages and/or dendritic cells) after burn injury in experimental mouse models (2,21,36,37) and humans (10). In our studies, we did not distinguish whether the APCs responsible for injury-induced immune suppression were monocytes/macrophages vs dendritic cells, because we used a mixture of anti-F4/80 and anti-CD11c mAbs to isolate the cells.…”
Section: Discussionmentioning
confidence: 94%
“…Mice received a third-degree full-thickness scald burn as previously described [7,10,25]. Briefly, the mice were anesthetized by intraperitoneal injection of 65 mg/kg body weight pentobarbital sodium, and the entire dorsal surface was shaved.…”
Section: Thermal Injury Proceduresmentioning
confidence: 99%
“…The surviving mice were killed by methoxyflurane overdose at 7 days after injury, the time of maximal immunosuppression [10], and the spleens were removed aseptically. Splenocyte suspensions were prepared in complete media (RPMI 1640 containing 10% heat-inactivated fetal bovine serum, 50 µM ␤-mercaptoethanol, and 5 µg/mL gentamicin, GIBCO BRL, Grand Island, NY) as described elsewhere [10,25].…”
Section: Preparation Of Splenic Macrophagesmentioning
confidence: 99%
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