Mechanisms of high-density lipoprotein cholesterol effects on the endothelial function in hyperlipemia

Lupattelli, Graziana; Marchesi, Simona; Lombardini, Rita; Siepi, Donatella; Bagaglia, Francesco; Pirro, Matteo; Ciuffetti, Giovańni; Schillaci, Giuseppe; Mannarino, Elmo

doi:10.1016/s0026-0495(03)00157-4

Cited by 56 publications

(38 citation statements)

References 29 publications

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“…In contrast with our patients and control groups of normolipidemic subjects, Lupatelli, et al 9) and Abe, et al 10) investigated the effect of low HDL-c on sCAM levels in hyperlipidemic subjects. Lupatelli, et al 9) found that low HDL-c was associated with higher sVCAM-1 and sICAM-1 levels, whereas Abe, et al 10) observed an association with three sCAMs: sVCAM-1, sICAM-1, and sE-selectin. However, Calabresi, et al 8) reported increased sICAM-1 and sE-selectin concentrations in both normolipidemic and hyperlipidemic subjects with low plasma HDL-c values.…”

Section: Discussionmentioning

confidence: 68%

“…This is in disagreement with the results of several studies conducted by other authors in different settings, which reported the association of high sCAM with low HDL-c concentrations. [8][9][10] This difference could be attributed to the different study design and patient selection. In contrast with our patients and control groups of normolipidemic subjects, Lupatelli, et al 9) and Abe, et al 10) investigated the effect of low HDL-c on sCAM levels in hyperlipidemic subjects.…”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10] This difference could be attributed to the different study design and patient selection. In contrast with our patients and control groups of normolipidemic subjects, Lupatelli, et al 9) and Abe, et al 10) investigated the effect of low HDL-c on sCAM levels in hyperlipidemic subjects. Lupatelli, et al 9) found that low HDL-c was associated with higher sVCAM-1 and sICAM-1 levels, whereas Abe, et al 10) observed an association with three sCAMs: sVCAM-1, sICAM-1, and sE-selectin.…”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10] In the present study, we investigated the relationship between HDL-c and sCAM (sICAM-1, sVCAM-1 and sE-selectin) levels in normolipidemic CAD patients and healthy individuals who were matched according to age and gender.…”

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confidence: 99%

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<b>Lack of Association Between Low HDL-cholesterol and Elevated Circulating Cellular Adhesion Molecules in Normolipidemic CAD Patients and Healthy Subjects</b>

N¹,

Ivanovic²,

Djurovic

et al. 2005

Int. Heart J.

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SUMMARYHigh plasma HDL-cholesterol (HDL-c) is a well-established protective factor in coronary artery disease (CAD). One of its potential protective mechanisms is the inhibition of the cytokine-induced upregulation of expression of cellular adhesion molecules (CAMs). High sCAM levels were found to be associated with low HDL-c in some studies performed mostly in hyperlipidemic subjects, but this association has not yet been investigated in CAD patients. In addition, conflicting results were obtained from in vitro studies that explored the proposed HDL effect on cytokine-induced CAM expression. The aim of the present case-control study was to investigate whether low HDL-c values are associated with CAM overexpression in normolipidemic CAD patients and healthy individuals, matched according to age and gender. Plasma HDL-c, sICAM-1, sVCAM-1, and sEselectin were measured in 37 normolipidemic patients with angiographically verified coronary artery disease and in 52 healthy normolipidemic subjects. The sCAM values obtained in the subjects (patients or controls) with low HDL-c levels (< 1.03 mmol/L) were compared with the values in the subjects with high HDL-c (≥ 1.03 mmol/L). No significant difference was found between sICAM-1, sVCAM-1, and E-selectin values obtained in subjects with low and high HDL-c, either among the patients or the healthy controls. In conclusion, low HDL-c levels are not associated with CAM overexpression in normolipidemic CAD patients and healthy subjects. (Int Heart J 2005; 46: 593-600)

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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<b>Lack of Association Between Low HDL-cholesterol and Elevated Circulating Cellular Adhesion Molecules in Normolipidemic CAD Patients and Healthy Subjects</b>

N¹,

Ivanovic²,

Djurovic

et al. 2005

Int. Heart J.

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“…These molecules mediate the adhesion of leukocytes to the endothelium and therefore, contribute to a proinflammatory state. 57 Low HDL-C is also associated with increased low-density lipoprotein cholesterol (LDL-C) oxidation and impaired FMD. 58 The HDL-C has the ability to act as an antioxidant and has been shown to inhibit lipoprotein oxidation.…”

Section: Dyslipidemia-low Hdl-c and Hypertriglyceridemiamentioning

confidence: 99%

Endothelial Dysfunction and Metabolic Syndrome

Lee¹,

Khambhati²,

Bhargava³

et al. 2017

Hypertension Journal

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Atherosclerotic cardiovascular disease (ASCVD) continues to be the leading cause of death worldwide. Metabolic syndrome is associated with an increased risk of ASCVD. With the prevalence of metabolic syndrome continuing to increase, it is important to understand the relationship between these risk factors and development of ASCVD. Endothelial dysfunction (ED), an early, essential step in atherosclerotic plaque formation, is the key link. Here we review diagnostic methods of ED and the mechanisms of each metabolic syndrome component contributing to ED. Finally, the effects of current treatments of metabolic syndrome on ED will also be discussed.

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Hypercholesterolemia Influences the Progression of Cancer by Changing the Biomolecular and Immunological Status of the Tumor Microenvironment

Özdemir

2023

Handbook of Cancer and Immunology

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Mechanisms of high-density lipoprotein cholesterol effects on the endothelial function in hyperlipemia

Cited by 56 publications

References 29 publications

<b>Lack of Association Between Low HDL-cholesterol and Elevated Circulating Cellular Adhesion Molecules in Normolipidemic CAD Patients and Healthy Subjects</b>

<b>Lack of Association Between Low HDL-cholesterol and Elevated Circulating Cellular Adhesion Molecules in Normolipidemic CAD Patients and Healthy Subjects</b>

Endothelial Dysfunction and Metabolic Syndrome

Hypercholesterolemia Influences the Progression of Cancer by Changing the Biomolecular and Immunological Status of the Tumor Microenvironment

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