<b>Lack of Association Between Low HDL-cholesterol and Elevated Circulating Cellular Adhesion Molecules in Normolipidemic CAD Patients and Healthy Subjects</b>

Abstract

SUMMARYHigh plasma HDL-cholesterol (HDL-c) is a well-established protective factor in coronary artery disease (CAD). One of its potential protective mechanisms is the inhibition of the cytokine-induced upregulation of expression of cellular adhesion molecules (CAMs). High sCAM levels were found to be associated with low HDL-c in some studies performed mostly in hyperlipidemic subjects, but this association has not yet been investigated in CAD patients. In addition, conflicting results were obtained from in vitro studies that explored the proposed HDL effect on cytokine-induced CAM expression. The aim of the present case-control study was to investigate whether low HDL-c values are associated with CAM overexpression in normolipidemic CAD patients and healthy individuals, matched according to age and gender. Plasma HDL-c, sICAM-1, sVCAM-1, and sEselectin were measured in 37 normolipidemic patients with angiographically verified coronary artery disease and in 52 healthy normolipidemic subjects. The sCAM values obtained in the subjects (patients or controls) with low HDL-c levels (< 1.03 mmol/L) were compared with the values in the subjects with high HDL-c (≥ 1.03 mmol/L). No significant difference was found between sICAM-1, sVCAM-1, and E-selectin values obtained in subjects with low and high HDL-c, either among the patients or the healthy controls. In conclusion, low HDL-c levels are not associated with CAM overexpression in normolipidemic CAD patients and healthy subjects. (Int Heart J 2005; 46: 593-600)

Independent Association of High Serum Uric Acid Concentration with Angiographically Defined Coronary Artery Disease

“…To date no such studies have been conducted in Southeastern European countries such as Serbia. The results reported herein, together with our previous reports considering other risk factors within the Serbian population (BogavacStanojevic 2003;Bogavac-Stanojevic 2005;Memon et al 2006), represent important pieces in the overall puzzle representing population-based relationships between lipid and non-lipid risk factors and the development of CAD. To minimise the effect of interfering factors it would have been optimal if we could have compared the values obtained in CAD patients with the corresponding values found in a population of stenosis-free patients with the same characteristics instead of the healthy control population.…”

A meal rich in oleic acid beneficially modulates postprandial sICAM-1 and sVCAM-1 in normotensive and hypertensive hypertriglyceridemic subjects

“…TG-enriched HDL particles are more rapidly catabolized by lipases, thereby resulting in cholesterol depleted HDL particles. It is interesting to note that sICAM-1 and sVCAM-1 are positively associated with low HDL-C concentrations in subjects with fasting hypertriglyceridemia [18] but not in subjects with normal levels of TG [19]. These observations highlight the importance of TG and TG enrichment of HDL particles secondary to fasting hypertriglyceridemia in the values of sICAM-1 and sVCAM-1.…”

Paraoxonase 1 and atherosclerosis‐related diseases

“…During the last twenty years, we have explored mutual involvement of dyslipidemia, inflammation, and oxidative stress in vascular disease‐related pathologies. Initial studies focused on lipid status and inflammation . Subsequent interest in the roles of oxidative stress, antioxidative protection, and PON1 was a logical progression and formed an integral part of our research.…”

“…Initial studies focused on lipid status and inflammation. 47,48 Subsequent interest in the roles of oxidative stress, antioxidative protection, and PON1 was a logical progression and formed an integral part of our research. Inconsistencies in research findings regarding the above-mentioned PON1 polymorphism obscured its association with vascular disease.…”