Mechanisms of Heavy Metal Toxicities

Oehme, Frederick W.

doi:10.3109/15563657208990995

Cited by 50 publications

(23 citation statements)

References 32 publications

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“…Mercury also forms strong bonds with other ligands, such as amine, phosphoryl and carboxyl groups, which may contribute to the toxicity of mercury (Oehme, 1972;Ellenhorn & Barceloux, 1988). …”

Section: Discussionmentioning

confidence: 99%

“…It is then redistributed preferentially to the kidney and secondarily accumulates in When soluble mercuric compounds, including HgCl 2 , are ingested, 7-15% are rapidly absorbed, the majority within the first 15 min (Ellenhorn & Barceloux, 1988), although a considerable portion remains fixed to the alimentary mucosa and intestinal contents (Oehme, 1972 (2004) the liver. It is chiefly excreted in the urine, but considerable quantities are also passed in the faeces through secretion into the gastrointestinal tract via bile, saliva and gastric and intestinal juices (Oehme, 1972). Most of the mercury is excreted within 1 week, but low levels may be found in the urine and faeces for months (Oehme, 1972).…”

Section: Long-term Experimentsmentioning

confidence: 99%

“…It is chiefly excreted in the urine, but considerable quantities are also passed in the faeces through secretion into the gastrointestinal tract via bile, saliva and gastric and intestinal juices (Oehme, 1972). Most of the mercury is excreted within 1 week, but low levels may be found in the urine and faeces for months (Oehme, 1972). If a massive amount is ingested, volume loss as a result of intra-abdominal fluid shifts and capillary leakage secondary to gastrointestinal lesions may lead to shock and vascular collapse and can cause death within a few hours.…”

Section: Long-term Experimentsmentioning

confidence: 99%

“…However, mortality in the two groups was similar (2 × 2 chi-squared test). (2004) absorbed mercury passes into the blood, it is distributed in roughly equal proportion between red blood cells and plasma, where it is firmly bound to the sulphydryl groups of albumin (Oehme, 1972). It is then redistributed preferentially to the kidney and secondarily accumulates in When soluble mercuric compounds, including HgCl 2 , are ingested, 7-15% are rapidly absorbed, the majority within the first 15 min (Ellenhorn & Barceloux, 1988), although a considerable portion remains fixed to the alimentary mucosa and intestinal contents (Oehme, 1972 (2004) the liver.…”

Section: Long-term Experimentsmentioning

confidence: 99%

“…(2004) absorbed mercury passes into the blood, it is distributed in roughly equal proportion between red blood cells and plasma, where it is firmly bound to the sulphydryl groups of albumin (Oehme, 1972). It is then redistributed preferentially to the kidney and secondarily accumulates in When soluble mercuric compounds, including HgCl 2 , are ingested, 7-15% are rapidly absorbed, the majority within the first 15 min (Ellenhorn & Barceloux, 1988), although a considerable portion remains fixed to the alimentary mucosa and intestinal contents (Oehme, 1972 (2004) the liver. It is chiefly excreted in the urine, but considerable quantities are also passed in the faeces through secretion into the gastrointestinal tract via bile, saliva and gastric and intestinal juices (Oehme, 1972).…”

Section: Long-term Experimentsmentioning

confidence: 99%

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Effect of milk on intestinal fluid accumulation and renal injury following mercuric chloride ingestion in rats

Kamijo

Hayashi

Yoshimura

et al. 2004

J of Applied Toxicology

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To investigate the effect of milk on intestinal fluid accumulation and renal injury following mercuric chloride (HgCl(2)) ingestion, 10 ml kg(-1) of saline or 10 mg kg(-1) of HgCl(2) dissolved in 10 ml kg(-1) of water or raw milk was administered enterally to rats and the mercury content in biological samples was determined by cold vapour atomic absorption spectrometry. Three hours after administration, the intestinal water content in rats that received HgCl(2) in water (group S2) was significantly higher than in rats that received saline (group S1) (P < 0.01) or HgCl(2) in milk (group S3) (P < 0.01). The amount of mercury detected per gram dry weight of small intestine was higher in group S2 than in group S3 (P < 0.05). Seventy-two hours after administration, both the serum urea nitrogen and creatinine concentrations in rats that received HgCl(2 )in milk (group L3) were significantly higher than in rats that received saline (group L1) (P < 0.05) or HgCl(2) in water (group L2) (P < 0.05). Mercury levels in many of the biological samples in group L3 were higher than in group L2 (P < 0.05). Milk may reduce the intestinal cytotoxicity of mercury but it promotes its absorption, which may lessen intestinal fluid accumulation but worsen renal injury.

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Section: Discussionmentioning

confidence: 99%