Hemodialysis of Acute Arsenic Intoxication With Transient Renal Failure

A, Giberson; Vaziri, N.D.; Mirahamadi, K; Rosen, S. M.

doi:10.1001/archinte.1976.03630110065017

Cited by 29 publications

(5 citation statements)

References 4 publications

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“…There are several reports of using BAL with EBP for acute Ars poisoning in the setting of impaired kidney function. In two anuric patients treated with BAL, Ars removal was between 50 and 100% greater with even low flux-HD compared to that removed by their residual kidney function, consistently removing between 2 and 6 mg of Ars per treatment [8, 24]. With more modest degrees of renal impairment, Ars removal with HD is still considerable, but less important than native kidney removal.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, one report described 10.7 mg of Ars eliminated by the kidneys over 24 h in a patient with a serum creatinine of 27 mg/L, compared to only 8.2 mg eliminated by a 4 h high flux HD session [10]. Importantly, the efficacy of Ars removal with EBP is often expressed as clearance, and which is sometimes not increased by BAL [8, 10, 24, 25]. This should not be misinterpreted as showing limited efficacy – in all cases, BAL increased the serum concentration of Ars available to EBP per unit time, leading to greater removal (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the lack of definitive data, DMPS combined high-flux HD or HDF should be considered in acute Ars poisoning in auric patients. This recommendation is based on the observations of Adam above and also other reported cases [8, 10, 24]. If DMPS is given orally, EBP should be commenced within 2 h of the administrating the chelator, as the urinary excretion of Ars by normal functioning kidneys appears to be the greatest in the first 2 h [52].…”

Section: Discussionmentioning

confidence: 99%

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Treatment of lead and arsenic poisoning in anuric patients – a case report and narrative review of the literature

2019

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Background Heavy metal poisoning can cause debilitating illness if left untreated, and its management in anuric patients poses challenges. Literature with which to guide clinical practice in this area is rather scattered. Case presentation We present a case of symptomatic lead and arsenic poisoning from use of Ayurvedic medicine in a 28-year-old man with end-stage kidney disease on chronic hemodialysis. We describe his treatment course with chelating agents and extracorporeal blood purification, and review the relevant literature to provide general guidance. Conclusion Cumulative clinical experience assists in identifying preferred chelators and modalities of extracorporeal blood purification when managing such patients. However, a larger body of real-world or clinical trial evidence is necessary to inform evidence-based guidelines for the management of heavy metal poisoning in anuric patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Treatment of lead and arsenic poisoning in anuric patients – a case report and narrative review of the literature

2019

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“…In nature, gold and arsenic-loaded substances coexist in the rocks, and minerals, there is consistently a danger of release of arsenic during gold mining activities. These toxic elements are also color pigments readily used in the cosmetic industry in the manufacturing of eye-shadows [15]. It is also found out to be present in the preparatory solutions of electronic cigarettes and the smoke they release.…”

Section: Anthropogenic Sourcesmentioning

confidence: 97%

Arsenic Contamination in South Asian Regions: Sources, Challenges and Vision for the Abstract Future

Awan¹,

Batool²,

Naz³

et al. 2021

PJC

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The contamination of groundwater due to a heavy metal such as arsenic, causes a risk to the availability of clean drinking water around the world. South Asian regions, specifically Bangladesh, India, and Pakistan are reported to be the worst hit of arsenic contamination, with the rural and the distant areas being almost totally relying on arsenic contaminated water. The arsenic contamination of ground water reservoir, is the outcome of various natural and anthropogenic sources, prompting antagonistic impacts on the climate and human well-being. Reliability on such arsenic-loaded water prompts serious health issues such as arsenicosis, skin cancer, cardiac disorders, and respiratory disorders, etc. It has become the necessity of the time to outline the economic and reliable techniques which all the nations whether developed or developing, can successfully adopt for the deduction of arsenic contamination from water. The purpose of this study is to explain the crises caused by naturally occurring arsenic in ground water, challenges faced by humans due to widespread arsenic in South Asian region and modern technologies to mitigate this impact. This article also highlights the importance of the improvements required in the research field for assessments and analysis of drinking water resources, and the development of new methods for the mitigation of chronic toxicity of arsenic.

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“…Renal toxicity due to arsenic exposure may lead to  Acute tubular necrosis resulting in acute renal failure (Giberson et al 1976).  Chronic renal insufficiency due to cortical necrosis.…”

Section: B Renal Effectsmentioning

confidence: 99%