Mechanisms of drug release from advanced drug formulations such as polymeric-based drug-delivery systems and lipid nanoparticles

Son, Gi-Ho; Lee, Beom‐Jin; Cho, Cheong-Weon

doi:10.1007/s40005-017-0320-1

Cited by 225 publications

(101 citation statements)

References 59 publications

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“…The derived values are listed in Table 6. For the initial stage (first 6 h), the release profiles fitted well with the Korsmeyer-Peppas model [67,68]. Meanwhile, AmB@ABA obtained an n value of 0.68 for the supposed spherical particles, indicating an anomalous behaviour.…”

Section: Release Studymentioning

confidence: 54%

Development of Amphotericin B Micellar Formulations Based on Copolymers of Poly(ethylene glycol) and Poly(ε-caprolactone) Conjugated with Retinol

et al. 2020

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Amphotericin B (AmB) is a broad spectrum of antifungal drug used to treat antifungal diseases. However, due to the high toxicity of AmB, treated patients may suffer the risk of side effects, such as renal failure. Nanoencapsulation strategies have been reported to elicit low toxicity, albeit most of them possess low encapsulation efficiency. The aim of this research is to develop micellar delivery systems for AmB with reduced toxicity while maintaining its affectivity by employing retinol (RET)-conjugated amphiphilic block copolymers (ABCs) as precursors. Copolymers composed of poly(ε-caprolactone) (A) and polyethylenglycol (B) of types AB and ABA were synthesized by ring opening polymerization and subsequently conjugated with RET by Steglich esterification. 1H-NMR spectroscopy was used to corroborate the structure of copolymers and their conjugates and determine their molecular weights. Analysis by gel permeation chromatography also found that the materials have narrow distributions. The resulting copolymers were used as precursors for delivery systems of AmB, thus reducing its aggregation and consequently causing a low haemolytic effect. Upon conjugation with RET, the encapsulation capacity was enhanced from approximately 2 wt % for AB and ABA copolymers to 10 wt %. AmB encapsulated in polymer micelles presented improved antifungal efficiency against Candida albicans and Candida auris strains compared with Fungizone®, as deduced from the low minimum inhibitory concentration.

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Section: Release Studymentioning

confidence: 54%

Development of Amphotericin B Micellar Formulations Based on Copolymers of Poly(ethylene glycol) and Poly(ε-caprolactone) Conjugated with Retinol

et al. 2020

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“…Under equivalent conditions, the release rate of VRS was signifi cantly faster than that of DTX (p <0.01). This could be attributable to the higher hydrophobicity of DTX (logP ~3) than VRS (logP ~2) [45,46] . In addition, there was a remarked increase in the percent VRS and DTX released from LPH in acidic conditions (pH 5.5) compared to that released under normal physiological environment (pH 7.0) after 24 h (p<0.01 in comparison of release percent in acidic and neutral pH of DTX).…”

Section: Resultsmentioning

confidence: 99%

Synergistic Therapeutic Strategy of Dual Drug-loaded Lipid Polymer Hybrid Nanoparticles for Breast Cancer Treatment

Tran¹,

Nguyen²,

Chen³

et al. 2019

pharmaceutical-sciences

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Tran et al.: Dual Drug-loaded Lipid Polymer Hybrid Nanoparticles In this investigation, a smart nanocarrier-loaded docetaxel, a microtubules disrupting agent and vorinostat, a histone deacetylase inhibitor was developed to achieve a synergistic anticancer effect. Dual drug-loaded lipid polymer hybrid nanoparticles were prepared, with easy fabrication and favourable properties including small size, narrow distribution and a high loading effi cacy. The in vitro drug release conducted in phosphatebuffered saline, pH 7.4 and acetate-buffered saline, pH 5.5 media demonstrated the sustained, pH-dependent release profi le. The nanoparticles were effectively taken up by cells, which ensured greater suppression of cell growth. The co-delivery of both drugs exhibited a synergistic effect on the induction of cancer cell apoptosis, resulting in greater inhibition of SCC-7, MCF-7, and MDA-MB-231 cancer cells by the drug-loaded carrier. These promising results may lead to clinical applications with enhanced docetaxel activity.

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“…Gradually, the chitosan shell of SACPNs would be eroded by the physiological environment, resulting in the release of drugs from the shell. Besides, different stimuli from the physiological environment, such as pH changes and ionic strength changes, would weaken the electrostatic interactions between chitosan and phospholipid, leading to the swelling of SACPNs and triggering the release of drugs encapsulated in the lipid cores of SACPNs (Son et al, 2017).…”

Section: Drug Release Mechanism Of Sacpnsmentioning

confidence: 99%

Self-Assembled chitosan/phospholipid nanoparticles: from fundamentals to preparation for advanced drug delivery

Gao

Sun

et al. 2020

Drug Delivery

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Mechanisms of drug release from advanced drug formulations such as polymeric-based drug-delivery systems and lipid nanoparticles

Cited by 225 publications

References 59 publications

Development of Amphotericin B Micellar Formulations Based on Copolymers of Poly(ethylene glycol) and Poly(ε-caprolactone) Conjugated with Retinol

Development of Amphotericin B Micellar Formulations Based on Copolymers of Poly(ethylene glycol) and Poly(ε-caprolactone) Conjugated with Retinol

Synergistic Therapeutic Strategy of Dual Drug-loaded Lipid Polymer Hybrid Nanoparticles for Breast Cancer Treatment

Self-Assembled chitosan/phospholipid nanoparticles: from fundamentals to preparation for advanced drug delivery

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