Self-Assembled chitosan/phospholipid nanoparticles: from fundamentals to preparation for advanced drug delivery

Engineering Carbohydrate-Based Particles for Biomedical Applications: Strategies to Construct and Modify

“…For example, nanoparticles based on the negatively charged carboxymethyl pachyman (CMP) and the positively charged chitosan were prepared using the polyelectrolyte complexation method . PEC is a simple, cost-effective method where linkages are formed in situ by simply mixing oppositely charged components in solution without involving organic solvents or cross-linking agents. Self-assembly: Self-assembly involves the self-organization of the component to a higher-order structure. , The amphiphilic copolymers are obtained upon grafting of hydrophilic polymeric chains with a hydrophobic segment. These copolymers undergo intra/intermolecular interactions between hydrophobic groups in aqueous conditions to obtain micellar structure or micelle-like aggregates that possess unique properties such as small particle size with core–shell structure and thermodynamic stability depending on the hydrophilic/hydrophobic constituents of copolymers. …”

New Acaciin-Loaded Self-Assembled Nanofibers as MPro Inhibitors Against BCV as a Surrogate Model for SARS-CoV-2

“… 18 The process utilizes the self-assembly approach which allows both lecithin and chitosan to assemble spontaneously by electrostatic interactions without using electric current, hazardous organic solvents or cross-linking agents. 19 Finally, the ACA-loaded NFs were tested against BCV to reveal their effect on the virus development which depends on the mechanistic hindrance of viral entry to the cells, as well as inhibition of RNA replication.…”

<p>Self-Assembled Lecithin/Chitosan Nanoparticles Based on Phospholipid Complex: A Feasible Strategy to Improve Entrapment Efficiency and Transdermal Delivery of Poorly Lipophilic Drug</p>

“…This is partly because LCNs possess advantages such as simple and mild self-assembled process, suitable biocompatibility, and biodegradability. [1][2][3] The effectiveness of LCNs is as a result of the desirable characteristics of the constitutive materials. Chitosan, a natural positively charged polysaccharide, is a frequently applied mucoadhesive polymer with various unique biological characteristics, such as remarkable bioadhesive to mucosal surfaces and ability to open tight junctions in epithelial cells to strongly promote drug penetration.…”

“…The inner core is the hydrophobic lipid and can be utilized for encapsulation of lipophilic drugs, whereas the hydrophilic chitosan constitutes the outer shell and provides stabilization. 1 LCNs possess the integrated advantages of lecithin and chitosan, which can extend the retention time of drugs at the target site and promote drug penetration. [1][2][3] Due to the enhanced mucoadhesiveness and penetration, LCNs hold great potential to improve the permeation of encapsulated drugs across various biological barriers by transdermal, mucosal, ocular and oral routes.…”

“…1 LCNs possess the integrated advantages of lecithin and chitosan, which can extend the retention time of drugs at the target site and promote drug penetration. [1][2][3] Due to the enhanced mucoadhesiveness and penetration, LCNs hold great potential to improve the permeation of encapsulated drugs across various biological barriers by transdermal, mucosal, ocular and oral routes. 1,3,4,6,15,16 Drugs are encapsulated with LCNs for effective delivery and penetration at the site of action.…”